DRD3 Ser9Gly Polymorphism Is Related to Thermal Pain Perception and Modulation in Chronic Widespread Pain Patients and Healthy Controls

Potvin, Stéphane; Larouche, Annie; Normand, Edith; Souza, Juliana Barcellos de; Gaumond, Isabelle; Grignon, Sylvain; Marchand, Serge

doi:10.1016/j.jpain.2009.03.013

Cited by 89 publications

(64 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is also increased evidence that COMT is associated with increased psychologic vulnerability (Finan et al, 2011). Another study reported that a dopamine-D-3 receptor Ser9Gly polymorphism influenced diffuse noxious inhibitory control efficacy and pain tolerance in FMS patients (Potvin et al, 2009). There has also been evidence for the association of FMS with various adrenergic receptor gene polymorphisms (Vargas-Alarcon et al, 2009).…”

Section: Pathogenesismentioning

confidence: 99%

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides

Tsilioni

Arbetman

et al. 2015

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Fibromyalgia syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain, affecting primarily women. It is clinically characterized by chronic, nonarticular pain and a heightened response to pressure along with sleep disturbances, fatigue, bowel and bladder abnormalities, and cognitive dysfunction. The diagnostic criteria have changed repeatedly, and there is neither a definitive pathogenesis nor reliable diagnostic or prognostic biomarkers. Clinical and laboratory studies have provided evidence of altered central pain pathways. Recent evidence suggests the involvement of neuroinflammation with stress peptides triggering the release of neurosenzitizing mediators. The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management. Here we review recent data on the pathogenesis and propose new directions for research and treatment.

show abstract

Section: Pathogenesismentioning

confidence: 99%

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides

Tsilioni

Arbetman

et al. 2015

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…Thirty-three studies were identified by electronic or manual searching, and twenty-two were selected for a full-text review based on title and abstract details [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][36][37][38]. Four studies were excluded because they were reviews [5,36,37] or because they did not concern fibromyalgia [38].…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Four studies were excluded because they were reviews [5,36,37] or because they did not concern fibromyalgia [38]. Thus, eighteen studies met the inclusion criteria [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Of these, three studies contained data on two different groups [7,12,20].…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…All studies of three polymorphisms showed the genotype and allele frequencies of the polymorphisms except for Cohen et al's study giving only allele data [20]. There was one study for adrenergic receptor A1A (ADRA1A) [7], adrenergic receptor B2 (ADRB2) [7], adrenergic receptor B3 (ADRB3) [7], dopamine-D 3 -receptor (DRD3) [8], dopamine-D 4 -receptor (DRD4) [17], dopamine transporter (DAT) [10], 5-HT2A receptor (rs6311) [11], COMT (rs6269, rs4633, rs4818, rs4680, rs20907, and rs16559) [12], monoamine oxidase-A (MAO-A) [promoter variable number tandem repeat (VNTR), 941G/T] [13], monoamine oxidase-B (MAO-B) [13], endothelial nitric oxide synthase (eNOS) [14], tachykinin NK1 (substance P) receptor (TACR1) [10], alpha-1 antitrypsin (AAT) [10], interleukin-4 (IL-4) [15], 5-HTTLPR (intron2 VNTR) [19], 5-HT receptor 3A, and 3B (HTR3A and 3B) (some SNPs) [16], respectively (Tables 1, 2). We performed a meta-analysis on the association of the polymorphisms with fibromyalgia if there were at least two comparisons.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Significant familial aggregation, convincing demonstrations of genetic linkages and associations demonstrate an underlying genetic basis for fibromyalgia [5]. Many studies have examined the potential contribution of the candidate gene polymorphisms to fibromyalgia susceptibility, but these studies have produced diverse results [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Candidate gene studies of fibromyalgia: a systematic review and meta-analysis

et al. 2010

View full text Add to dashboard Cite

The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association between the C allele and fibromyalgia was 1.333 (95% CI = 1.053-1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C allele (OR = 1.541, 95% CI = 1.032-2.303, P = 0.035; OR = 1.838, 95% CI = 1.151-2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia. In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia.

show abstract