Translating Genetic Knowledge into Clinical Practice for Musculoskeletal Pain Conditions

Diatchenko, Luda; Smith, Shad B.; Maixner, William

doi:10.1002/9781118398890.ch10

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2015

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“…Transduction of these pain signals is modulated by inflammatory mediators. Researchers have investigated biomarkers within these pain pathways (e.g., inflammatory markers, molecular receptors detecting metabolites that influence pain, and neurotransmitters) involved in conduction, synaptic transmission, or modulation of pain response as therapeutic targets (Diatchenko, Smith, & Maixner, 2014; James, 2013). However, there is a need to synthesize current studies evaluating the effects of exercise on these biomarkers to assess their translational value in chronic pain.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exercise on Select Biomarkers and Associated Outcomes in Chronic Pain Conditions

Kawi

Lukkahatai

Inouye

et al. 2015

Biological Research For Nursing

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It remains a question whether biomarkers can be used as objective measures for risk assessment, diagnosis, or evaluation or as surrogate endpoints in chronic pain. Adequate sample sizes, optimal exercise dose determination, study replications, and longitudinal research studies with consistent methodologies are warranted. Regardless, the potential translational value of biomarkers in chronic pain is evident. Advancing nursing research in biomarkers is vital for moving the nursing discipline and clinical chronic pain practice forward. Developing a biobehavioral perspective in chronic pain is also necessary for comprehensive management.

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Section: Introductionmentioning

confidence: 99%