DRB1*1613N: a novel DRB1 allele with a premature termination codon

Zhao, Weicheng; Guerrero, Edward; Kerman, R. H.; Cano, Pedro; Fernandez-Vina, M

doi:10.1111/j.1399-0039.2007.00990.x

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Hla High‐resolution Typing Results: Statistics 2009a1

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“…Compared with HLA‐A and ‐B, only a few DRB1 null mutants have been identified so far (4–7): 66 HLA‐A null variants, 57 HLA‐B and 6 HLA‐DRB1, including the DRB1*12:24N (IMGT/HLA database v 3.1 released July 2010). The length of the variable region of the DBR1 gene is smaller (exon 2: 270 bp) than that of the class I genes (exon 2 + 3: 546 bp).…”

Section: Hla High‐resolution Typing Results: Statistics 2009amentioning

confidence: 99%

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Sandt¹,

Mahieu²,

Emonds³

2011

Tissue Antigens

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Human leukocyte antigen (HLA) high-resolution matching is routinely performed in the case of hematopoietic stem cell transplantation. Misdiagnosis of rare or new variants will result in additional unknown mismatches that can trigger graft versus host disease and/or graft failure. Using a mono allelic sequencing strategy, we obtained >90% first-step sequence-based high-resolution typing results, conforming to the standards set down by the European Federation for Immunogenetics. During this routine analysis, eight new HLA alleles were identified, including one DRB1*12 null variant, DRB1*12:24N and three other coding mutants, resulting in a change of properties of the corresponding antigens.

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Section: Hla High‐resolution Typing Results: Statistics 2009amentioning

confidence: 99%

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Sandt¹,

Mahieu²,

Emonds³

2011

Tissue Antigens

View full text Add to dashboard Cite

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Nomenclature for Factors of the HLA System, Update February 2008

Marsh

2008

Human Immunology

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Nomenclature for factors of the HLA system, update February 2008

Marsh

2008

Tissue Antigens

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DRB1*1613N: a novel DRB1 allele with a premature termination codon

Abstract: DRB1 null alleles are extremely rare and always sporadic, suggesting their biological selective disadvantage.

Cited by 5 publications

References 4 publications

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Nomenclature for Factors of the HLA System, Update February 2008

Nomenclature for factors of the HLA system, update February 2008

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DRB1*1613N: a novel DRB1 allele with a premature termination codon

Abstract: DRB1 null alleles are extremely rare and always sporadic, suggesting their biological selective disadvantage.

Cited by 5 publications

References 4 publications

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB1*12:24N allele

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB1*12:24N allele

Nomenclature for Factors of the HLA System, Update February 2008

Nomenclature for factors of the HLA system, update February 2008

Contact Info

Product

Resources

About

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele