Draft Genome Sequence of Toxigenic
            <i>Corynebacterium ulcerans</i>
            Strain 04-7514, Isolated from a Dog in France

Guimarães, Luís Carlos; Viana, Marcus Vinícius Canário; Benevides, Leandro de Jesus; Mariano, Diego; Veras, Adooney A. O.; Sá, Pablo Henrique Caracciolo Gomes de; Rocha, Flávia Souza; Boas, Priscilla C. B. Vilas; Soares, Siomar C.; Barbosa, Maria Silvanira; Guiso, Nicole; Badell, Edgar; Carneiro, Adriana Ribeiro; Azevedo, Vasco; Ramos, Rommel Thiago Jucá; Silva, Artur M. S.

doi:10.1128/genomea.00172-16

Genome Announc

2016

DOI: 10.1128/genomea.00172-16

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Draft Genome Sequence of Toxigenic Corynebacterium ulcerans Strain 04-7514, Isolated from a Dog in France

Luís Carlos Guimarães

Marcus Vinícius Canário Viana

Leandro de Jesus Benevides

et al.

Abstract: Here, we present the draft genome of toxigenic Corynebacterium ulcerans strain 04-7514. The draft genome has 2,497,845 bp, 2,059 coding sequences, 12 rRNA genes, 46 tRNA genes, 150 pseudogenes, 1 clustered regularly interspaced short palindromic repeat (CRISPR) array, and a G+C content of 53.50%.

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Cited by 3 publications

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Novel configurations of type I-E CRISPR-Cas system in Corynebacterium striatum clinical isolates

Ramos

Baio²,

Veras

et al. 2022

Braz J Microbiol

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Clustered regularly interspaced short palindromic repeats (CRISPR) are a prokaryotic adaptive immune system that, through Cas proteins, promote the degradation of foreign nucleic acids such as phages and plasmids. We analyzed 10 genomes of Corynebacterium striatum clinical isolates from a public hospital in Rio de Janeiro, Brazil, the most emergent multidrug-resistant Corynebacterium species. All isolates were submitted to antimicrobial susceptibility testing. The occurrence and diversity of the CRISPR system were investigated by bioinformatics tools. Our analysis revealed that the isolates exhibited type I-E gene arrangements, and 3 more multidrug-resistant isolates, alternative type I-E gene arrangements, showing a divergent gene arrangement within the cas operon. Phylogenetic analysis of the cas1 gene of this type I-E CRISPR-Cas system alternative arrangement, termed here type I-E’, showed a cluster in a distinct clade of the type I-E CRISPR-Cas system. The systems’ guanine-cytosine (GC) content is lower than the genomic DNA’s GC content, and mobile genetic elements were found in some isolates near the CRISPR-Cas system. Most CRISPR spacers are unknown indicating that there is a reservoir of unexplored corynebacteriophages and plasmids. Some spacers showed perfect homologies with phage and plasmid sequences. Intact phage regions were found in 3 of our isolates, ranging from 9.1 to 43.8 kb, with regions showing similarity to Rhodococcus and Corynebacterium phages. Our results may contribute to research about the CRISPR-Cas system diversity in C. striatum, where there are no published data to date.

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Novel configurations of type I-E CRISPR-Cas system in Corynebacterium striatum clinical isolates

Ramos

Baio²,

Veras

et al. 2022

Braz J Microbiol

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Genome sequence of a pathogenic Corynebacterium ulcerans strain isolated from a wild boar with necrotizing lymphadenitis

et al. 2019

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ObjectivesCorynebacterium ulcerans can colonize a wide variety of animals and also humans are infected, typically by zoonotic transmission. Symptoms range from skin ulcers or systemic infections to diphtheria-like illness. In contrast, Corynebacterium pseudotuberculosis is widely distributed among herds of sheep, goats and other farm animals, where it causes high economic losses due to caseous lymphadenitis. Here we describe the genome sequence of an atypical C. ulcerans strain isolated from a wild boar with necrotizing lymphadenitis. This strain has similarities to C. pseudotuberculosis.Data descriptionGenome sequence data of C. ulcerans isolate W25 were generated, analyzed and taxonomical relationship to other Corynebacterium species as well as growth properties of the isolate were characterized. The genome of C. ulcerans W25 comprises 2,550,924 bp with a G+C content of 54.41% and a total of 2376 genes.

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Corynebacterium Ulcerans , an Emerging Human Pathogen

et al. 2016

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While formerly known infections of Corynebacterium ulcerans are rare and mainly associated with contact to infected cattle, C. ulcerans has become an emerging pathogen today. In Western Europe, cases of respiratory diphtheria caused by C. ulcerans have been reported more often than infections by Corynebacterium diphtheria, while systemic infections are also increasingly reported. Little is known about factors that contribute to host colonization and virulence of this zoonotic pathogen. Research in this field has received new impetus by the publication of several C. ulcerans genome sequences in the past years. This review gives a comprehensive overview of the basic knowledge of C. ulcerans, as well as the recent advances made in the analysis of putative virulence factors.

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Draft Genome Sequence of Toxigenic Corynebacterium ulcerans Strain 04-7514, Isolated from a Dog in France

Cited by 3 publications

References 7 publications

Novel configurations of type I-E CRISPR-Cas system in Corynebacterium striatum clinical isolates

Novel configurations of type I-E CRISPR-Cas system in Corynebacterium striatum clinical isolates

Genome sequence of a pathogenic Corynebacterium ulcerans strain isolated from a wild boar with necrotizing lymphadenitis

Corynebacterium Ulcerans , an Emerging Human Pathogen

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