Dracunculus and Dracunculiasis

Müller, R.

doi:10.1016/s0065-308x(08)60160-8

Cited by 149 publications

(95 citation statements)

References 77 publications

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“…For example, during the I~~O S , piped water was provided to Igbo-ora, a Nigerian town of abour 30 ooo people. Within two years, the incidence rate of dracunculiasis declined from more than 60% to zero (Muller 1971). However, the civil war in southern Sudan and the isolation of the population hinders the implementation of an efficient water programme.…”

Section: Discussionmentioning

confidence: 99%

Guinea worm disease in Ayod, Upper Nile Province, southern Sudan: a cross‐sectional study

Guthmann¹,

Mercer

Gandubert³

et al. 1996

Tropical Med Int Health

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Summary Upper Nile Province is one of the four main endemic areas for Guinea worm disease in the Sudan. In December 1994, a survey was conducted in the village of Ayod where the disease is endemic, to investigate morbidity and local knowledge of transmission and prevention. Interviews were conducted in households selected by standard cluster sampling procedures and of the 759 people examined, 156 (20.6%) had Guinea worm lesions. Adjusted odds ratios were used to estimate the relative risk for people with different personal or household characteristics in a multivariate analysis. After controlling for the possible confounding effects of other study variables, having a filter in the household, gender, and lack of knowledge about transmission and about prevention, were not associated with lesions. Only two variables were significantly associated with Guinea worm disease: getting water from a source other than a well increased the risk by a factor of 2.3, and being aged 5 years or more increased the risk by a factor of 31.1. This study demonstrates the clear association between the source of water for drinking and Guinea worm disease found elsewhere. We suggest the provision of reliable sources of pure drinking water and health education are the most suitable long‐term preventive measures. The Sudan now represents the greatest challenge to the goal of global eradication of Guinea worm disease, following the reduction in cases in Nigeria. The continuing civil war and insecurity in southern Sudan hinder the implementation of an effective water programme and other control measures, but the potential benefits through reduced incapacity and improved agricultural productivity are considerable.

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Section: Discussionmentioning

confidence: 99%

Guinea worm disease in Ayod, Upper Nile Province, southern Sudan: a cross‐sectional study

Guthmann¹,

Mercer

Gandubert³

et al. 1996

Tropical Med Int Health

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“…However, there are two possibilities of recurrence of Dracunculus in tribal areas (i) some hidden isolated cases could not be detected during the survey and (ii) the infection might have reached from previously hyper endemic neighboring states viz., Gujarat and Madhya Pradesh. It may further be conjectured that the drinking water source of the present case may be contaminated by the reservoir hosts, the monkeys (Muller 1968(Muller , 1971) and dogs (Moorthy and Sweet 1936;Chun-Sun 1958;Litvinov and Lysenko 1982) which are found abundantly in the area. It is interesting and surprising that just after a few days of this case, one more case of dracunculiasis was detected in the Madiya Fala village of Dungarpur district (Dainik Bhaskar 2006).…”

mentioning

confidence: 86%

“…Before two decades, Rajasthan state was endemic for this disease (Chopra 1967;Tiwari 1968;Joshi 1981;Sharma 1984;Johnson 1985), but tribal region of southern Rajasthan (Banswara, Dungarpur and Udaipur districts) was worst affected or hyperendemic for dracunculiasis (Muller 1971). Therefore, the Government of Rajasthan had launched a project (SWACHProject-1986) to eradicate this dreaded disease from the state of Rajasthan.…”

mentioning

confidence: 99%

Dracunculiasis in tribal region of southern Rajasthan, India: a case report

Choubisa¹,

Verma²,

Choubisa³

2010

J Parasit Dis

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“…D.medinesis (a little dragon from Medina) is the causative agent and it is the only species from the 12 species of Dracunculus [7][8][9][10] which infects humans, commonly known as "Guinea Worm Disease (GWD)". The other Dracunculus species generally resides in the internal tissues and body cavities of non-human mammals and reptiles (snake and turtles) [11].…”

Section: Sonu Mishra and Virendra S Gomasementioning

confidence: 99%

Identification of Antigenic Determinants, Solvent Accessibility and MHC Binders of Antigen NADH Dehydrogenase Subunit 5 from a Little Dragon from Medina (Dracunculusmedinensis)

Mishra¹,

Gomase²

2016

Drug Des

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Dracunculiasis caused by the pathogen Dracunculus medinensis (a little dragon from Medina). The Cyclops is the intermediate host that ingests the larvae of parasite (D. medinensis), that later on ingested by the human from the contaminated stagnant unfiltered water from the water source. After an incubation period of a year these mature female worm comes towards the skin and start formation of a small round bulge on the skin by secreting an irritating chemical which causes severe pain. In this study we will summarize the potency of NADH dehydrogenase subunit 5 (mitochondrion) from Dracunculus medinensis with 527 amino acids. Antigenic peptide of NADHdehydrogenasesubunit5 protein is most suitable for subunit vaccine development because with single epitope, the immune response can be generated in large population. In this research, we used PSSM and SVM algorithms for the prediction of MHC class I and II binding peptide, antigenicity, Solvent accessibility, polar and nonpolar residue to analyse the regions that are likely exposed on the surface of proteins which are potentially antigenic that allows potential drug targets to identify active sites against infection as well as to design effective drug to treat it.

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Dracunculus and Dracunculiasis

Cited by 149 publications

References 77 publications

Guinea worm disease in Ayod, Upper Nile Province, southern Sudan: a cross‐sectional study

Guinea worm disease in Ayod, Upper Nile Province, southern Sudan: a cross‐sectional study

Dracunculiasis in tribal region of southern Rajasthan, India: a case report

Identification of Antigenic Determinants, Solvent Accessibility and MHC Binders of Antigen NADH Dehydrogenase Subunit 5 from a Little Dragon from Medina (Dracunculusmedinensis)

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