DQA1 and DQB1 association and nasal polyposis

Fajardo-Dolci, Germán; Solorio-Abreu, Jesús; Romero-Álvarez, Julio César; Zavaleta-Villa, Beatriz; Cerezo-Camacho, Oscar; Jiménez-Lucio, Rocío; Olivo-Dı́az, Angélica

doi:10.1016/j.otohns.2006.03.034

Cited by 37 publications

(26 citation statements)

References 26 publications

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“…For the IL-10 polymorphisms, primers and probes for SNPs at positions −592, −819, and −1082 described by Meenagh et al (2002) were used. IL-8 and IL-10 probes were labeled with digoxigenin-11-ddUTP, and alleles were identified by dot blot analysis with chemiluminescence as in Fajardo-Dolci et al (2006).…”

Section: Subjectsmentioning

confidence: 99%

Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis

et al. 2012

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The intestinal protozoan parasite Blastocystis is one of the most common parasites worldwide in humans and, although its ability to cause human disease has been questioned, some reports have demonstrated that this microorganism is associated to the development of irritable bowel syndrome (IBS) and to a proinflammatory response, in which the expression of some cytokines is unregulated. Since inflammatory cytokine gene polymorphisms might have a role in the pathophysiology of IBS, we assessed the role of single nucleotide polymorphisms (SNPs) for interleukin (IL)-8 and IL-10, in previously collected DNA samples from IBS patients and controls, with or without Blastocystis infection. IL-8+396(G) and IL-10-1082 (A) alleles (p=0.0437 and p=0.0267, respectively), as well as their homozygous (p<0.0001 and p=0.0039, respectively) and IL-8+781(CT) (p=0.0248) genotypes were significantly overrepresented in patients with IBS in comparison with controls. IL-8+396(GG) genotype was relevant because it was associated to IBS (p<0.0001), to Blastocystis (p=0.0025), and to IBS–Blastocystis (p=0.0272). In the latter binomial association, this genotype presented a high contribution (etiological fraction =0.452) and a risk >fourfold to develop IBS. IL-8+781 (T) and IL-10-592 (C) alleles were also associated to Blastocystis and to IBS–Blastocystis, respectively (p=0.0448 and p=0.0166). Our results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers.

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Section: Subjectsmentioning

confidence: 99%

Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis

et al. 2012

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“…Genotypes of IL1A (4845G, 4845T), IL1B (−5111C, −5111T), and TNFA (−238G, −238A and −308G, −308A) were determined by restriction fragment length polymorphism analyses after PCR with appropriate primers according to the slightly modified procedures previously described. 8,11 The 4845G, 4845T polymorphism of the IL1A gene was identified after digestion with the restriction enzyme SatI, which yielded 124-, 76-, and 29-base pair (bp) bands in the presence of allele G, as well as 153-and 76-bp bands in the presence of allele A.…”

Section: Genotypingmentioning

confidence: 99%

Proinflammatory Cytokine Single Nucleotide Polymorphisms in Nasal Polyposis

Erbek¹,

Yurtçu²,

Erbek³

et al. 2007

Arch Otolaryngol Head Neck Surg

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“…According to the results of Erbek et al (7), AA polymorphism in the TNF-α-308 promoter region was higher in the control group. Bernstein et al (9) found that the TNF-α A allele at position -308 increased the formation of NP almost two-fold compared to the control groups, whereas Erbek et al (7), Mfuna Endam et al (4), and Fajardo-Dolci et al (10) found no statistically significant difference between TNF-α genotypes or allelic frequencies and NP development. Szabó et al (20) found the A allele to be a risk factor for NP development only when acetylsalicylic acid sensitivity was present.…”

Section: Discussionmentioning

confidence: 98%

“…Some authors claim that the TNF-α GA polymorphism in the -308 promoter region is a risk factor for NP development, whereas others have found that the A allele frequency is a risk factor (7)(8)(9). Some authors have found no relationship between the TNF-α GA polymorphism and NP development (4,10).…”

Section: Introductionmentioning

confidence: 99%

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

İsmi¹,

Özcan²,

Polat³

et al. 2017

Turk Arch Otorhinolaryngol

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Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms. Methods:A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group. Blood was gathered into EDTA-containing tubes, and patient DNA was extracted. The polymorphisms of the IL-β and TNF-α cytokine genes were analyzed using real time polymerase chain reaction. Results:The GG genotype in the TNF-α-308 region and the CC genotype in the IL-1β-511 region were found to be risk factors for NP formation (OR: 9.2, p=0.007 and OR: 33.3, p=0.001, respectively). Regarding allelic frequencies, the G allele at the TNF-α-308 promoter region was a risk factor for NP formation (OR: 6.06, p<0.001).Conclusion: TNF-α GG genotype in the -308 promoter region and the IL-1β CC genotype in the -511 region are genetic risk factors for NP formation.

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DQA1 and DQB1 association and nasal polyposis

Abstract: B-2b.

Cited by 37 publications

References 26 publications

Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis

Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis

Proinflammatory Cytokine Single Nucleotide Polymorphisms in Nasal Polyposis

TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis

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