DPPH radical scavenging activity of xylo-oligosaccharides mixtures of controlled composition: A step forward in understanding structure–activity relationship

Fuso, Andrea; Dejonghe, Winnie; Cauwenberghs, Lieve; Rosso, Ginevra; Rosso, Franco; Manera, Ileana; Caligiani, Augusta

doi:10.1016/j.jff.2023.105417

Cited by 16 publications

(6 citation statements)

References 36 publications

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“…Integration was performed by extracting the following mass ions ( m / z ) for deacetylated xylo‐oligosaccharides (XOSs): 149 for xylose, 281 for degree of polymerization DP = 2, 413 for DP = 3, 545 for DP = 4, 677 for DP = 5, 809 for DP = 6, 941 for DP = 7, 1073 for DP = 8, 1205 for DP = 9, and 1337 for DP = 10. For acetylated XOSs, numerous mass ions can be theoretically present, 24 and the presence of each of them was checked by extracting the corresponding fragment. The various XOSs were semi‐quantified, calculating ratios between peak areas, because an exact quantification was not possible due to the lack of each standard compound.…”

Section: Methodsmentioning

confidence: 99%

“…On the contrary, relevant percentages of DP = 7, 8, and 9, equal to 16% of the total XOSs, appeared when 150 °C was selected as the operative temperature. This should be kept in mind when such treatments are applied, since it was shown in previous studies how XOSs with higher DPs seem to improve their antioxidant potential 24 and smaller DPs seemed better in stimulating the growth of many prebiotic bacteria. 34 Another interesting result concerns xylose: vast quantities emerged at 200 °C (78% of total XOSs), indicating a rather strong xylan degradation into its monomer.…”

Section: Distribution Profile Of Xossmentioning

confidence: 99%

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Hazelnut (Corylus avellana L.) shells as a potential source of dietary fibre: impact of hydrothermal treatment temperature on fibre structure and degradation compounds

et al. 2023

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BackgroundHemicellulose extraction from lignocellulosic biomasses has gained interest over the years, and hydrothermal treatment is one of the most common methods employed for this purpose. This work aimed to deeply study hazelnut (Corylus avellana L.) shells as a new source of dietary fibre, evaluating the effect of hydrothermal treatment temperatures on the type and structure of fibre extracted, but also on the formation of side‐products derived from lignocellulose degradation.ResultsDifferent process temperatures led to diverse polysaccharides in the hydrothermal extract. Pectin was identified for the first time in hazelnut shells when experimenting with extraction at 125 °C, whereas at 150 °C a heterogeneous mixture of pectin, xylan, and xylo‐oligosaccharides was present. The highest yield in terms of total fibre was gained at 150 and 175 °C, and then decreased again at 200 °C. Finally, more than 500 compounds from different chemical classes were putatively identified and they appeared to be present in the extracted fibre with a different distribution and relative amount, depending on the heat treatment severity. A generally high content of phenols, phenyls, oligosaccharides, dehydro‐sugars, and furans was observed.ConclusionsModulation of the hydrothermal treatment temperature allows fibre extracts with very different compositions, and therefore different potential end uses, to be obtained from hazelnut shells. A sequential temperature‐based fractionation approach, as a function of the severity of the extraction parameters, can also be considered. Nevertheless, the study of the side‐compounds formed from lignocellulosic matrix degradation, as a function of the applied temperature, needs to be fully addressed for a safe introduction of the fibre extract within the food chain. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Section: Methodsmentioning

confidence: 99%

Section: Distribution Profile Of Xossmentioning

confidence: 99%

Hazelnut (Corylus avellana L.) shells as a potential source of dietary fibre: impact of hydrothermal treatment temperature on fibre structure and degradation compounds

et al. 2023

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“…The percent inhibition values of Plant A and B extracts at six different concentrations are given in Table 3. Also, the IC 50 value defined as the concentration of sample that may reduce 50% of DPPH free radical was calculated for all of them [54]. The highest activity was detected in L‐Ascorbic acid with an IC 50 value of 0.033 mg/mL.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Akpınar,

Yıldırım Baştemur,

Bıçak

et al. 2023

J of Separation Science

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Polygonum cognatum Meissn, a perennial herbaceous belonging to the Polygonaceae family, is an aromatic plant. High‐performance liquid chromatography/diode array detector method was developed and validated for the phytochemical analysis of the plant. Also, various methods were used to investigate the antioxidant, antimicrobial, and cytotoxic activities of the methanolic extracts. Antioxidant activities were researched by 2,2′‐diphenyl‐1‐picrylhydrazyl and cupric reducing antioxidant capacity methods. Among the tested standard microbial strains, Candida albicans was found to be more sensitive with a 24.60 ± 0.55 mm inhibition zone according to the diffusion tests. In the microdilution tests, the minimum inhibitory concentration and minimum bactericidal/fungicidal concentration values were 4.75 and ≥ 4.75 mg/mL, respectively, for all tested pathogens. Human colon carcinoma cells were used to investigate cytotoxicity by using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyl tetrazolium bromide analysis (IC50 = 2891 μg/mL for Plant A, IC50 = 3291 μg/mL for Plant B). Molecular docking and absorption, distribution, metabolism, excretion, and toxicity analysis were used to explain inhibition mechanisms of major phenolic compounds of plants against Tankyrase 1, Tankyrase 2 enzymes, and deoxyribonucleic acid gyrase subunit B and found compatible with experimental results.

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“…Similarly, Zhang et al [ 62 ] demonstrated that the antioxidant activity of XOS follows the trend of concentration variation. A study by Andrea [ 63 ] found that DP 2–6 XOS had a low scavenging capacity while DP 6–9 XOS 75 had a high scavenging capacity.…”

Section: Resultsmentioning

confidence: 99%

Thermodynamics and Physicochemical Properties of Immobilized Maleic Anhydride-Modified Xylanase and Its Application in the Extraction of Oligosaccharides from Wheat Bran

Zhao

Guo

et al. 2023

Foods

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Xylanases are the preferred enzymes for the extracting of oligosaccharides from wheat bran. However, free xylanases have poor stability and are difficult to reuse, which limit their industrial application. In the present study, we covalently immobilized free maleic anhydride-modified xylanase (FMA-XY) to improve its reusability and stability. The immobilized maleic anhydride-modified xylanase (IMA-XY) exhibited better stability compared with the free enzyme. After six repeated uses, 52.24% of the activity of the immobilized enzyme remained. The wheat bran oligosaccharides extracted using IMA-XY were mainly xylopentoses, xylohexoses, and xyloheptoses, which were the β-configurational units and α-configurational units of xylose. The oligosaccharides also exhibited good antioxidant properties. The results indicated that FMA-XY can easily be recycled and can remain stable after immobilization; therefore, it has good prospects for future industrial applications.

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DPPH radical scavenging activity of xylo-oligosaccharides mixtures of controlled composition: A step forward in understanding structure–activity relationship

Cited by 16 publications

References 36 publications

Hazelnut (Corylus avellana L.) shells as a potential source of dietary fibre: impact of hydrothermal treatment temperature on fibre structure and degradation compounds

Hazelnut (Corylus avellana L.) shells as a potential source of dietary fibre: impact of hydrothermal treatment temperature on fibre structure and degradation compounds

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Thermodynamics and Physicochemical Properties of Immobilized Maleic Anhydride-Modified Xylanase and Its Application in the Extraction of Oligosaccharides from Wheat Bran

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