DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses

Kim, Boram; Kim, Hyo Young; Choi, Inhee; Kim, Jin-Baek; Jin, Chang Hyun; Han, Ah‐Reum

doi:10.3390/molecules23081998

Cited by 67 publications

(64 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extensive studies on the phytochemical-based DPP-IV inhibitors were undertaken in the literature [ 19 , 20 , 21 ], and in our previous studies [ 16 , 22 ]. Flavonoids and phenolic compounds were found to be the DPP-IV inhibitors with potent to mild activities, showing IC 50 values in the range of 0.12 to 63.26 μM.…”

Section: Resultsmentioning

confidence: 99%

“…The five factors that affect diabetes treatment are dipeptidyl peptidase- IV (DPP-IV), α-glucosidase inhibitors, aldose reductase (ALR) inhibitors, phatase 1B (PTP1B) inhibitors and peroxisome proliferator-activated receptor-γ (PPAR-γ) [ 15 ]. Recently, incretin-based therapies for the treatment of type 2 diabetes mellitus have begun to appear, one of which is DPP-IV inhibitors [ 16 ]. The incretin system includes glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which in response to high blood sugar levels induce the release of insulin from the pancreatic β-cell [ 13 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, incretin-based therapies for the treatment of type 2 diabetes mellitus have begun to appear, one of which is DPP-IV inhibitors [ 16 ]. The incretin system includes glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which in response to high blood sugar levels induce the release of insulin from the pancreatic β-cell [ 13 , 16 ]. DPP- IV is involved in the quick degradation and inactivation of GLP-1 and GIP in the incretin system [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…As a result, DPP-IV inhibition enhances the glucose-producing effect of GLP-1, thereby improving glucose tolerance in diabetic patients [ 18 ]. As DPP-IV inhibitors, synthetic chemical compounds or natural product-derived compounds recently represent promising drug candidates [ 16 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Constituents of Coreopsis lanceolata Flower and Their Dipeptidyl Peptidase IV Inhibitory Effects

et al. 2020

Self Cite

View full text Add to dashboard Cite

A new polyacetylene glycoside, (5R)-6E-tetradecene-8,10,12-triyne-1-ol-5-O-β-glucoside (1), was isolated from the flower of Coreopsis lanceolata (Compositae), together with two known compounds, bidenoside C (10) and (3S,4S)-5E-trideca-1,5-dien-7,9,11-triyne-3,4-diol-4-O-β-glucopyranoside (11), which were found in Coreopsis species for the first time. The other known compounds, lanceoletin (2), 3,2′-dihydroxy-4-3′-dimethoxychalcone-4′-glucoside (3), 4-methoxylanceoletin (4), lanceolin (5), leptosidin (6), (2R)-8-methoxybutin (7), luteolin (8) and quercetin (9), were isolated in this study and reported previously from this plant. The structure of 1 was elucidated by analyzing one and two dimensional nuclear one-dimensional and two-dimensional nuclear magnetic resonance and high resolution-electrospray ionization-mass spectrometry data. All compounds were tested for their dipeptidyl peptidase IV (DPP-IV) inhibitory activity and compounds 2-4, 6 and 7 inhibited DPP-IV activity in a concentration-dependent manner, with IC50 values from 9.6 to 64.9 μM. These results suggest that C. lanceolata flower and its active constituents show potential as therapeutic agents for diseases associated with type 2 diabetes mellitus.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Constituents of Coreopsis lanceolata Flower and Their Dipeptidyl Peptidase IV Inhibitory Effects

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the present study, S. platensis significantly (P < 0•05, P < 0•01 and P < 0•001) inhibited DPP-IV enzyme activity, indicating that butanol fraction can enhance endogenous glucagon-like peptide 1 and glucose-dependent insulinotropic polypepide activity. A recent study has shown that flavonol glycosides from the seeds of Lens culinaris Medikus (Fabaceae) inhibited DPP-IV enzyme activity in the dose-dependent manner (48) . Therefore, it is anticipated that the same phytochemical constituents of S. platensis may be responsible for the observed DPP-IV inhibitory activity effect.…”

Section: Discussionmentioning

confidence: 99%

Effects of Spirulina platensis on insulin secretion, dipeptidyl peptidase IV activity and both carbohydrate digestion and absorption indicate potential as an adjunctive therapy for diabetes

et al. 2020

View full text Add to dashboard Cite

Spirulina platensis (S. platensis) has previously been shown in both animals and humans to be useful in the treatment of type 2 diabetes. The present study aims to elucidate the effects of ethanol extract and butanol fraction of S. platensis on insulin release and glucose homeostasis in type 2 diabetic rats, together with their mechanism of actions. Both in vitro and in vivo methods were used including cellular studies to determine potential role of ion channels and cAMP in the insulinotropic actions of the extracts. The ethanol extract and butanol fraction stimulated insulin release from mouse islets and pancreatic β-cells in a concentration-dependent manner. The butanol fraction also similarly stimulated insulin release from perfused rat pancreas. The insulin releasing action was augmented by glucose, isobutyl methylxanthine, tolbutamide and a depolarizing concentration of KCl. The insulin secretory effect was attenuated with diazoxide and verapamil and by omission of extracellular Ca2+. Butanol fraction was found to significantly inhibit DPP-IV enzyme activity. Moreover, butanol fraction improved glucose tolerance following oral glucose administration (2.5 g/kg b.w.). The butanol fraction was tested on 24 h starved rats given an oral sucrose load (2.5 g/kg b.w.) to examine possible effects on carbohydrate digestion and absorption. S. platensis substantially decreased post-prandial hyperglycemia after oral sucrose load and increased unabsorbed sucrose content throughout the gut. During in situ intestinal perfusion with glucose, the butanol fraction reduced glucose absorption and promoted gut motility. Finally, chronic oral administration of butanol fraction for 28 days significantly decreased blood glucose, increased plasma insulin, pancreatic insulin stores, liver glycogen and improved lipid profile. The characterization of active compounds from butanol fraction revealed the presence of p-coumaric acid, β-carotene, catechine and other antioxidant polyphenols. These findings indicate that S. platensis could be a novel adjunctive therapy for the management of type 2 diabetes.

show abstract

Natural compounds with DPP‐4 inhibitory effects: Implications for the treatment of diabetes

Yaribeygi

Atkin

Sahebkar

2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetes agents that decrease blood glucose by preventing the degradation of endogenous glucagon-like peptide-1. The first DPP-4 was sitagliptin followed by several other agents in the class introduced to manage diabetes. Recent studies have suggested that naturally occurring compounds can exert an antidiabetes effect through DPP-4 inhibition. Such compounds may have a place in the treatment of diabetes within the diet; however, while DPP-4 inhibition alone is not associated with hypoglycemia, in combinations with other medication hypoglycemia can result, therefore, it is critical to know what herbal or food-based compounds may have these activities in the management of diabetes patients. In this review, we have outlined the compounds that have DPP-4 inhibition that may have utility in the treatment of diabetes. K E Y W O R D Salkaloids, diabetes mellitus, dipeptidyl peptidase-4 inhibitors, glycosides, herbal compounds, phenol 2 | DM CLASSIFICATION DM is commonly classified into type 1, 2, and gestational diabetes. 13 Type 1 DM (T1DM) accounts for 5% to 10% of all

show abstract

DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses

Cited by 67 publications

References 24 publications

Constituents of Coreopsis lanceolata Flower and Their Dipeptidyl Peptidase IV Inhibitory Effects

Constituents of Coreopsis lanceolata Flower and Their Dipeptidyl Peptidase IV Inhibitory Effects

Effects of Spirulina platensis on insulin secretion, dipeptidyl peptidase IV activity and both carbohydrate digestion and absorption indicate potential as an adjunctive therapy for diabetes

Natural compounds with DPP‐4 inhibitory effects: Implications for the treatment of diabetes

Contact Info

Product

Resources

About