Natural compounds with DPP‐4 inhibitory effects: Implications for the treatment of diabetes

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetes agents that decrease blood glucose by preventing the degradation of endogenous glucagon-like peptide-1. The first DPP-4 was sitagliptin followed by several other agents in the class introduced to manage diabetes. Recent studies have suggested that naturally occurring compounds can exert an antidiabetes effect through DPP-4 inhibition. Such compounds may have a place in the treatment of diabetes within the diet; however, while DPP-4 inhibition alone is not associated with hypoglycemia, in combinations with other medication hypoglycemia can result, therefore, it is critical to know what herbal or food-based compounds may have these activities in the management of diabetes patients. In this review, we have outlined the compounds that have DPP-4 inhibition that may have utility in the treatment of diabetes. K E Y W O R D Salkaloids, diabetes mellitus, dipeptidyl peptidase-4 inhibitors, glycosides, herbal compounds, phenol 2 | DM CLASSIFICATION DM is commonly classified into type 1, 2, and gestational diabetes. 13 Type 1 DM (T1DM) accounts for 5% to 10% of all

Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats

“…An inverse relationship has been suggested also between flavonoid intake and T2DM risk [ 30 ]. Phytochemicals other than those tested, such as anthocyanin, aspalathin, chrysin, eriodictyol, hispidulin, kaempferol, lepidoside, mangiferin, naringenin, naringin, procyanidin, rhamnoside, terpenoids, vitexin and Lens culinaris extracts have been shown also to exhibit DPP-IV inhibitory activity [ 27 , 31 ]. In addition, a number of other plants (such as A. catechu, M. indica and A. marmelos ) have been reported to contain potential phenolic compounds that exert antioxidant effects and DPP-IV inhibitory activity [ 32 ].…”

In Vivo Studies of Inoculated Plants and In Vitro Studies Utilizing Methanolic Extracts of Endophytic Streptomyces sp. Strain DBT34 Obtained from Mirabilis jalapa L. Exhibit ROS-Scavenging and Other Bioactive Properties

“…As reported in previous studies [ 45 , 46 ], the mitigation of altered metabolism in diabetic rats may have resulted from the effect of secondary metabolites present in the microbial extract on DPP-4 and other free radical scavenging activities. The decrease in DPP-4 accumulation may be due to the interaction between secondary metabolites in the microbial extract and DPP-4 at active sites [ 47 ].…”

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

“…The estimates indicate the enhanced incidence rate of diabetes mellitus around the world which has resulted in designing a number of pharmacological options for its treatment and prevention [63][64][65][66]. Troxerutin is one of these pharmacological options which has shown great anti-diabetic activity.…”