Doxycycline Degradation by the Oxidative Fenton Process

Abstract

Doxycycline is a broad-spectrum tetracycline occurring in domestic, industrial, and rural effluents, whose main drawback is the increasing emergence of resistant bacteria. This antibiotic could be degraded by the so-called Fenton process, consisting in the oxidation of organic pollutants by oxygen peroxide (H2O2) in the presence of Fe2+. Experiments were performed according to an experimental Rotational Central Composite Design to investigate the influence of temperature (0–40.0°C), H2O2concentration (100–900 mg/L), and Fe2+concentration (5–120 mg/L) on residual doxycycline and total organic carbon concentrations. Whereas the final residual doxycycline concentration ranged from 0 to 55.8 mg/L, the oxidation process proved unable to reduce the total organic carbon by more than 30%. The best operating conditions were concentrations of H2O2and Fe2+of 611 and 25 mg/L, respectively, and temperature of 35.0°C, but the analysis of variance revealed that only the first variable exerted a statistically significant effect on the residual doxycycline concentration. These results suggest possible application of this process in the treatment of doxycycline-containing effluents and may be used as starting basis to treat tetracycline-contaminated effluents.

Modified‐release oral pellets for duodenum delivery of doxycycline hyclate

“…DOXY was chemically active with three pKa values (c.a., 3, 8, and 9) (Fares, Abedi‐Valugerdi, Hassan, & Potacova, ; Hoseini & Bagheri Gh, ). The chemical instability of DOXY was a concern that must be addressed (Borghi et al, ; Rasimick et al, ; Suarez et al, ). The storage stability should be investigated to further assess the quality of DMOP.…”

“…This might be explained that fluidized bed was efficient process in pharmaceutical industry on a larger scale (Faure, York, & Rowe, 2001 Gh, 2019). The chemical instability of DOXY was a concern that must be addressed (Borghi et al, 2015;Rasimick et al, 2010;Suarez et al, 2014).…”

“…Further, a scale-up test was performed to assure the reproducibility and feasibility of industrialization. Storage stability of the DMOP prepared was investigated by monitoring the chemical instability of DOXY (Borghi, Silva, Al Arni, Converti, & Palma, 2015;Rasimick, Wan, Musikant, & Deutsch, 2010;Suarez et al, 2014) (Tianjin, China). All materials were used as received.…”

Abatement of amoxicillin and doxycycline in binary and ternary aqueous solutions by gas-phase pulsed corona discharge oxidation

“…Although ozonation is an effective approach, its use brings additional costs as the ozone has be generated separately in the ozone generator and transferred to the wastewater treatment unit, and the residual ozone gas has to be recovered. The Fenton process is the most effective method of commonly used AOPs [27] [28] [29] but has the drawback of sludge formation when ferrous iron chemical is added to the system. This work focuses on investigation of process parameters with the aim of increasing the energy efficiency of the oxidation process.…”

Pharmaceutical preparations and illicit drugs as contaminating substances of surface and wastewater

“…Među farmaceutskim preparatima sa visokim potencijalom za štetan efekat na životnu sredinu nalaze se i antibiotici, koji dospevaju u životnu sredinu ne samo preko otpadnih voda iz farmaceutske i hemijske industrije već i putem kanalizacionog sistema, kao i putem domaćih životinja, jer se 25% do 75% unetih lekova izbacuje iz organizma u nepromenjenom obliku [21,22]. β-laktamski antibiotici su najčešće korišćeni antibiotici (pripadaju im penicilini).…”