Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency

Jiang, Airui; Song, Bin; Ji, Xiaoyuan; Peng, Fei; Wang, Houyu; Su, Yuanyuan; He, Yao

doi:10.1007/s12274-017-1850-6

Cited by 29 publications

(16 citation statements)

References 52 publications

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“…6 Since Zhang's team used erythrocyte membranes wrapped around nanoparticles for the first time to improve the biocompatibility of nanomaterials, 7 researchers have dedicated much effort to find more applications of biomimetic nanomaterials in the treatment of various diseases. [8][9][10][11][12][13][14][15] Various cell types have been developed, including macrophages, [16][17][18] T cells, 19,20 neutrophils, 21,22 stem cells, [23][24][25][26][27] red blood cells, [28][29][30][31][32] and platelets. 33,34 Biomimetic nanomaterials show many advantages, such as high biocompatibility, longer cycle life, inherent biodegradability, natural targeting ability of cells/tissues, high drug loading, and ability to cross biological barriers.…”

Section: Introductionmentioning

confidence: 99%

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Pei¹,

Huang²,

Chen³

et al. 2020

IJN

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Background Traditional nanoparticle-based drug delivery systems suffer from several limitations, such as easy clearance from blood and inaccurate targeting. Materials and Methods Here, we developed platelet membrane-coated nanoparticles (PM-NPs) to improve the precise delivery of drugs to tumor sites and enable a more efficient photothermal therapy (PTT) treatment. Results Mimicking the natural platelet membrane, nanoparticles containing drugs and photothermal agents were not recognized and cleared by the immune system; they could circulate in the blood for a long time and accumulate more efficiently at the tumor site, thus releasing more antitumor drugs and achieving better PTT effects. It is worth mentioning that, in this study, we found that tumors in mice treated with the platelet-mimicking nanoparticles were completely eliminated without recurrence during the observation period (up to 18 days). Conclusion This study provides a new strategy to design delivery systems of drugs or photothermal agents, whether in biotherapy or other fields.

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Section: Introductionmentioning

confidence: 99%

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Pei¹,

Huang²,

Chen³

et al. 2020

IJN

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Section: Nanoparticles and Erythrocytesmentioning

confidence: 99%

“…Various nanoparticles incorporated with drugs such as doxorubicin [154,155], valproate [156], fazudil [157] and pravastatin [158] and encapsulated into RBCs were tested. Entrapment of fluorescent silicone nanoparticles (SiNPs) with doxorubicin into RBCs allowed for a four-fold increase in the half-elimination time of doxorubicin from the mouse bloodstream (up to 7.31 ± 0.96 h) compared to such particles without RBCs [155]. The literature describes promising examples of the use of erythrocytes loaded with nanoparticles with unique optical properties, such as photostability and strong fluorescence, for in vivo imaging and tumor photodestruction, fluorescence imaging for tumor surgery and photoacoustic imaging [157,[159][160][161][162].…”

Section: Nanoparticles and Erythrocytesmentioning

confidence: 99%

Erythrocytes as Carriers: From Drug Delivery to Biosensors

et al. 2020

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Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from the carrier; as bioreactors with encapsulated enzymes performing the necessary reactions, while remaining inaccessible to the immune system and plasma proteases; or as a tool for targeted drug delivery to target organs, primarily to cells of the reticuloendothelial system, liver and spleen. To date, erythrocytes have been studied as carriers for a wide range of drugs, such as enzymes, antibiotics, anti-inflammatory, antiviral drugs, etc., and for diagnostic purposes (e.g., magnetic resonance imaging). The review focuses only on drugs loaded inside erythrocytes, defines the main lines of research for erythrocytes with bioactive substances, as well as the advantages and limitations of their application. Particular attention is paid to in vivo studies, opening-up the potential for the clinical use of drugs encapsulated into erythrocytes.Pharmaceutics 2020, 12, 276 2 of 44 property of RBCs allows to load them with biologically active substances of different molecular weights. For these reasons, erythrocytes are promising biocompatible cells for drug delivery.The methods for incorporating various substances into red blood cells differ in the way that substances penetrate the cells. The cause of permeability may be the pores' formation in the cell membrane due to a physical exposure (high voltage electric pulse [10,11] or ultrasound [12]). Drug molecules can also enter the RBCs by endocytosis in the presence of certain chemical compounds (for example, primaquine [13], vinblastine, chlorpromazine, hydrocortisone or tetracaine [14,15]), or using the cell-penetrating peptides bounded to the compound that should be encapsulated [16]. However, the most popular are different variants of osmotic methods.In some cases, RBCs are first exposed to a hyperosmotic pulse of a low molecular weight substance that penetrates very well through the cell membrane (for example, dimethyl sulfoxide (DMSO) [17,18] or glucose [19,20]). After washing the cells, which decreases the external concentration of these compounds and creates a gradient of their concentration between both sides of the RBC membrane, the target drug is introduced into the external volume. Water with this drug begins to enter into the cells to decrease the osmotic pressure there. The process ends when the gradient of DMSO or glucose disappears. The pores close and part of the drug remains into RBCs. Other, the most popular of the osmotic methods are hypoosmotic. These methods are based on creating a hypotonic environment around RBCs, which causes swelling of the cells and opening pores in the cellular membrane, through which therapeutic compounds can penetrate RBCs. Then, a hypertonic solution is introduced into the cell suspension. The pores close, the cells restore their original size, trapping the drug molecules inside the cell. Osmotic methods are divided into severa...

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“…Another interesting new frontier was using the particles as theranostic platforms [144,145]. In the example of Ji et al, for the first time that silicon quantum dots were shown to be used as drug carrier ( Figure 9) [146].…”

Section: Bio-applicationsmentioning

confidence: 99%

Optical Biosensing and Bioimaging With Porous Silicon and Silicon Quantum Dots (Invited Review)

Guan¹

2017

PIER

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Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency

Cited by 29 publications

References 52 publications

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

<p>Platelet-Mimicking Drug Delivery Nanoparticles for Enhanced Chemo-Photothermal Therapy of Breast Cancer</p>

Erythrocytes as Carriers: From Drug Delivery to Biosensors

Optical Biosensing and Bioimaging With Porous Silicon and Silicon Quantum Dots (Invited Review)

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