Doxorubicin loaded folate-targeted carbon nanotubes: Preparation, cellular internalization, in vitro cytotoxicity and disposition kinetic study in the isolated perfused rat liver

Folate-conjugated nanodiamond for tumor-targeted drug delivery

“…With the development of nanotechnology, in the treatment of tumor diseases, drugs conjugated or adsorbed onto nanocarriers have shown many advantages compared with free drugs, such as controlled drug release, altered drug biodistribution, prolonged drug circulation in the blood, and anti-multidrug resistance; these systems have become an interesting research topic. 9,10 Since PEG has advantageous biological properties, including high biocompatibility and the weak interactions between PEG and proteins, cells and immunogenic, it has been used extensively for coupling with biological molecules, such as proteins, enzymes, oligonucleotides, and growth factors. When linked to a therapeutic drug, this ligand can be exploited to carry the nonselective drug specically into the cancer cells.…”

Co-delivery of VP-16 and Bcl-2-targeted antisense on PEG-grafted oMWCNTs for synergistic in vitro anti-cancer effects in non-small and small cell lung cancer

“…This was shown by our comet assay, demonstrating the genotoxicity comparable to free VP-16 and the exceptional hemocompatibility. Moreover, coating with the polymers provided binding sites for a number of biologically active biomolecules, as was shown in case of cisplatin [25], doxorubicin [26], DNA/RNA [27,28] and others. To increase the chemical reactivity, the MWCNTs surface was oxidized.…”

Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats

“…Some processes associated with hepatic disease states are, however, expected to affect drug disposition to a greater or lesser extent. It could contribute to decreased activity of drug metabolizing enzymes, changes in hepatic blood circulation and haemodynamics and so on (Dinan et al, 2014;Pfeifer et al, 2014;Yeung et al, 2014). Therefore, the harm of rat liver tissues might result in decreased metabolism of loganin and morroniside.…”