Doxorubicin hydrochloride - Loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers for hyperthermic tumor cell treatment and controlled drug release

Radmansouri, Maryam; Bahmani, Ehsan; Sarikhani, Einollah; Rahmani, Keivan; Sharifianjazi, Fariborz; Irani, Mohammad

doi:10.1016/j.ijbiomac.2018.04.161

Cited by 114 publications

(37 citation statements)

References 28 publications

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“…Song et al synthesized polyurethane nanofibers with iron oxide nanoparticles for thermal cancer therapy, where the temperature reached 43 °C under AMF for 70 s [84]. Similarly, TiO 2 / cobalt ferrite/chitosan nanofibers were fabricated for cancer chemotherapy and magnetic therapy, where TiO 2 nanoparticles were mixed with cobalt ferrite to control the temperature rise, which contributed to its application in localized cancer therapy [85]. In another case, a smart electrospun nanofiber mesh was prepared with paclitaxel (PTX), MNPs and poly(ε-caprolactone) (PCL) to improve antitumor efficiency ( Fig.…”

Section: Magnetic-responsive Electrospun Fibersmentioning

confidence: 99%

Functional Electrospun Fibers for Local Therapy of Cancer

2020

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Despite great efforts and advancement in the treatment of cancer, tumor recurrence and metastasis remain significant challenges and demand novel therapy strategies. Recently, advances in biomaterials and drug delivery systems have facilitated the development of the local therapy of cancer, among which electrospun nanofibrous scaffolds show great promise owing to their porous structure, relatively large surface area, high drug loading capacity, similarity with the native extracellular matrix, and possibility of the combination of various therapies. Here, we review this rapidly developing field of electrospun nanofibrous scaffolds as a drug delivery system for cancer local therapy, in particular addressing stimuli-responsive drug release, as well as its combination with stem cell and immune therapy. Challenges and future perspectives are also discussed.

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Section: Magnetic-responsive Electrospun Fibersmentioning

confidence: 99%

Functional Electrospun Fibers for Local Therapy of Cancer

2020

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“…Manifold studies have been done to elevate the solubility of PTX by utilizing micro-and nanomaterials, such as liposomes, micelles, nano-crystallization, and polymeric nanoparticles (NPs). [11][12][13][14][15][16][17] Fabricating NCs from crude pharmaceutical agents, such as PTX, lessens the adverse side effects following injection. [18] Pharmaceutical NCs were introduced in the late 1990s and since then have attracted the attention of researchers.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Carboxymethyl Chitosan Nanoparticles to Deliver Paclitaxel for Melanoma Treatment

et al. 2020

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In the present study, the effectiveness of paclitaxel nanocrystals (PTX NCs) encapsulated in carboxymethyl chitosan (CMCS) nanoparticles (CMCS−PTX NPs) as an anticancer drug is evaluated. The CMCS nanoparticles are produced via a cross‐junction microfluidic device where the PTX/CMCS concentration and flow rates in the device are optimized. The dynamic light scattering data show that the PTX NCs have a median diameter size of 230±90 nm, while the size of CMCS−PTX NPs is roughly 270±30 nm. The zeta‐potential result indicates less negative surface charge for the CMCS−PTX NPs as compared to the PTX NCs. Moreover, scanning electron microscopy micrographs, differential scanning calorimetry thermograms, and X‐ray diffraction patterns reveal that the physicochemical properties of the drug remain unaltered after perfusion through the microfluidic device. Cytotoxicity and cell endocytosis of PTX NCs and CMCS−PTX NPs are evaluated in vitro using G361 melanoma‐positive skin cells. The results reveal that the CMCS−PTX NPs increase the cellular uptake and cytotoxicity compared to the PTX NCs alone. In addition, the antitumor effect of CMCS−PTX NPs on B16 melanoma indicates the great potential of CMCS as a promising nano‐carrier for PTX NCs drug with potent inhibitory effect on the tumor growth.

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“…Polymer and polymer composites are gaining increasing attention in various applications [9,[17][18][19][20][21][22]. This is due to the possibility to benefit from the combination of properties related to contributing constituents [23][24][25][26][27][28]. Due to high stiffness, full usage of materials and high strength composite columns have been increasingly used recently [29][30][31].…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%