Doxorubicin/gold nanoparticles coated with liposomes for chemo-photothermal synergetic antitumor therapy

Abstract

Hybrid liposome/metal nanoparticles are promising candidate drug-carriers for therapy of various diseases due to their unique photothermal effect. In this study, self-crystallized gold nanoparticles (Au NPs) and doxorubicin (DOX) were co-encapsulated within liposomes (Au/DOX-Lips) by thin film hydration and gel separation technology. The surface plasmon resonance bands of drug-carriers were controllable in the near-infrared (NIR) zone. When the complex liposome/metallic hybrids were irradiated by NIR light, they displayed higher endocytosis efficiency following the fracture of liposomal membranes and the release of Au NPs. Then, the Au NPs penetrated further into deeper tumor tissue to accomplish photothermal treatment. The Au/DOX-Lips showed an excellent antitumor effect, whose inhibition rate for tumor cells was up to 78.28%. In experiments on mice bearing tumors, the Au/DOX-Lips treated mice exhibited superior tumor suppression. This novel drug system provides huge potential for biomedical application.

2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine

“…Moreover, the photothermal conversion efficiency ( η ) of PEG@GeQDs was obtained according to previous methods, and the η value of PEG@GeQDs was estimated to be 45.9 % (see the Supporting Information for details), which is much higher than many PTAs, for instance, gold nanorods (21 %), BPQDs (28.4 %), boron nanosheets (42.5 %), Cu 2− x Se nanocrystals (22 %), MoS 2 nanosheets (24 %), Ti 3 C 2 nanosheets (30.6 %), and Bi 2 Se 3 nanosheets (31.1 %, Supporting Information, Table S1) . More recently, some novel nanoplatform‐based PTAs with similar or even higher photothermal conversion efficiency have been developed, such as multi‐branched gold nanoshells (70.9 %), Au/DOX‐Lip nanocarriers (47.55 %), and BV/PTX@Au@PDA/DOX (43.6 %) . Compared with these reported platforms, the 2D GeQDs‐based PTAs are much simpler and the synthetic method is facile with lower cost.…”

2D Monoelemental Germanene Quantum Dots: Synthesis as Robust Photothermal Agents for Photonic Cancer Nanomedicine

“…Theh ighest increase in temperature (DT)w as 55.5 8 8Cw hen the concentration of PEG@GeQDs was 200 mgmL À1 ,a nd the power of NIR laser was 2Wcm À2 (Figure 2c). [14,16] More recently,some novel nanoplatform-based PTAs with similar or even higher photothermal conversion efficiency have been developed, such as multi-branched gold nanoshells (70.9 %), [17] Au/DOX-Lip nanocarriers (47.55 %), [18] and BV/PTX@Au@PDA/DOX (43.6 %). [14,16] More recently,some novel nanoplatform-based PTAs with similar or even higher photothermal conversion efficiency have been developed, such as multi-branched gold nanoshells (70.9 %), [17] Au/DOX-Lip nanocarriers (47.55 %), [18] and BV/PTX@Au@PDA/DOX (43.6 %).…”

“…In sharp contrast, at emperature increase of only 3.8 8 8Cw as detected in H 2 O, suggesting the excellent photothermal effect of PEG@-GeQDs.M oreover,t he photothermal conversion efficiency (h)o fP EG@GeQDs was obtained according to previous methods, [3] and the h value of PEG@GeQDs was estimated to be 45.9 %(see the Supporting Information for details), which is much higher than many PTAs,f or instance,g old nanorods (21 %), BPQDs (28.4 %), boron nanosheets (42.5 %), Cu 2Àx Se nanocrystals (22 %), MoS 2 nanosheets (24 %), Ti 3 C 2 nanosheets (30.6 %), and Bi 2 Se 3 nanosheets (31.1 %, Supporting Information, Table S1). [14,16] More recently,some novel nanoplatform-based PTAs with similar or even higher photothermal conversion efficiency have been developed, such as multi-branched gold nanoshells (70.9 %), [17] Au/DOX-Lip nanocarriers (47.55 %), [18] and BV/PTX@Au@PDA/DOX (43.6 %). [19] Compared with these reported platforms,t he 2D GeQDs-based PTAs are much simpler and the synthetic method is facile with lower cost.…”

State of the Art Biocompatible Gold Nanoparticles for Cancer Theragnosis

“…Consequently, injected AuNPs can remain longer and are tumor-specifically retained; thus, they can be applied as a passive tumor targeting strategy. Many studies have reported that the AuNPs without any tumor-targeting domain are relatively more abundant in cancer tissues, owing to the EPR effect [ 70 , 71 , 72 ].…”