State of the Art Biocompatible Gold Nanoparticles for Cancer Theragnosis

Kang, Moon Sung; Lee, So Yun; Kim, Ki Su; Han, Dong‐Wook

doi:10.3390/pharmaceutics12080701

Cited by 109 publications

(65 citation statements)

References 126 publications

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“…AuNPs absorb incident light energy, and convert photon energy into heat. The rapid relaxation of hot electrons in targeted tissues generates localized heating capable of killing tumors, terming as plasmonic photothermal therapy (PTT) [ 74 , 75 , 76 ]. In recent years, NIR light has been used increasingly in PTT due to minimally invasive cancer treatment [ 73 ].…”

Section: Structure-dependent Photocatalytic Activitymentioning

confidence: 99%

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Liao

Jin

et al. 2020

IJMS

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This article presents a state-of-the-art review and analysis of literature studies on the morphological structure, fabrication, cytotoxicity, and photocatalytic toxicity of zinc oxide nanostructures (nZnO) of mammalian cells. nZnO with different morphologies, e.g., quantum dots, nanoparticles, nanorods, and nanotetrapods are toxic to a wide variety of mammalian cell lines due to in vitro cell–material interactions. Several mechanisms responsible for in vitro cytotoxicity have been proposed. These include the penetration of nZnO into the cytoplasm, generating reactive oxygen species (ROS) that degrade mitochondrial function, induce endoplasmic reticulum stress, and damage deoxyribonucleic acid (DNA), lipid, and protein molecules. Otherwise, nZnO dissolve extracellularly into zinc ions and the subsequent diffusion of ions into the cytoplasm can create ROS. Furthermore, internalization of nZnO and localization in acidic lysosomes result in their dissolution into zinc ions, producing ROS too in cytoplasm. These ROS-mediated responses induce caspase-dependent apoptosis via the activation of B-cell lymphoma 2 (Bcl2), Bcl2-associated X protein (Bax), CCAAT/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. In vivo studies on a mouse model reveal the adverse impacts of nZnO on internal organs through different administration routes. The administration of ZnO nanoparticles into mice via intraperitoneal instillation and intravenous injection facilitates their accumulation in target organs, such as the liver, spleen, and lung. ZnO is a semiconductor with a large bandgap showing photocatalytic behavior under ultraviolet (UV) light irradiation. As such, photogenerated electron–hole pairs react with adsorbed oxygen and water molecules to produce ROS. So, the ROS-mediated selective killing for human tumor cells is beneficial for cancer treatment in photodynamic therapy. The photoinduced effects of noble metal doped nZnO for creating ROS under UV and visible light for killing cancer cells are also addressed.

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Section: Structure-dependent Photocatalytic Activitymentioning

confidence: 99%

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Liao

Jin

et al. 2020

IJMS

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“…ECBs often take advantage of the unique chemical properties possessed by nanomaterials [ 14 , 15 , 16 ]. Particularly, metal nanoparticles (MNPs) are mostly used due to their biocompatibility, low toxicity, excellent conductivity, and high surface area [ 17 , 18 , 19 , 20 , 21 ]. Among many, gold (AuNPs), silver (AgNPs), and platinum NPs (PtNPs) are some of the most commonly utilized in ECBs [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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“…The DEF of GNPs is well-defi ned as "fraction of chemotherapeutic drug intake by cancer cells in the availability of GNPs to the fraction of drug intake by the cancer cells in lack of GNPs".It can alter with quantity and effectiveness of GNPs and their site inside infected cells. Gold Nanoparticles (GNPs) have may advantages because they possess straightforward synthesis, good biocompatibility, wide range sizes, simple and easy functionalization by the attachment of ligands neeeded to target cancer cells and their organelles or better life time in the blood stream [51].…”

Section: Radiotherapymentioning

confidence: 99%

A Review on Gold Nanoparticles (GNPs) and their Advancement in Cancer Therapy

Shabbir¹,

Muhammad²

2021

Int J Nanomater Nanotechnol Nanomed

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nano-tubes. Different nanoparticles that are used in the treatment of targeted cancer shown in Figure 1. Innovations in nanotechnology assure to renovate synthesis of drugs, drug delivery, and clinical trials. By knowing how the materials work perversely at a particular cell or component, investigators are exposing the huge therapeutic potential of nanoscale approaches [4]. Though the plentiful study is quiet in its initial periods, researchers and investigators are producing innovative tools and evolving novel approaches for fundamental study areas for the synthesis of

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State of the Art Biocompatible Gold Nanoparticles for Cancer Theragnosis

Cited by 109 publications

References 126 publications

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

A Review on Gold Nanoparticles (GNPs) and their Advancement in Cancer Therapy

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