Downregulation of OCT4 promotes differentiation and inhibits growth of BE (2)-C human neuroblastoma I-type cells

Yang, Lin; Zheng, Jicui; Xu, Tao; Xiao, Xianmin

doi:10.3892/or.2013.2356

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Multiple studies have documented the aberrant expression of OCT TFs in various types of cancer [50–58] including GBM [30, 59–63], and the enrichment of this group of TFs in a subpopulation of undifferentiated cancer stem cells indicated their critical role in tumor initiation, metastasis and resistance to chemotherapy. Expression of OCT4 was significantly higher in several malignancies and positively correlated with poor prognosis [64–66].…”

Section: The Oct Family Of Transcription Factorsmentioning

confidence: 99%

The role of octamer binding transcription factors in glioblastoma multiforme

Rooj

Bronisz

Godlewski

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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A group of transcription factors (TF) that are master developmental regulators of the establishment and maintenance of pluripotency during embryogenesis play additional roles to control tissue homeostasis and regeneration in adults. Among these TFs, members of the Octamer-binding transcription factor (OCT) gene family are well documented as major regulators controlling the self-renewal and pluripotency of stem cells isolated from different adult organs including the brain. In the last few years a large number of studies show the aberrant expression and dysfunction of OCT in different types of cancers including glioblastoma multiforme (GBM). GBM is the most common malignant primary brain tumor, and contains a subpopulation of undifferentiated stem cells (GSCs), with self-renewal and tumorigenic potential that contribute to tumor initiation, invasion, recurrence, and therapeutic resistance. In this review, we have summarized the current knowledge about OCT family in GBM and their crucial role in the initiation, maintenance and drug resistance properties of GSCs.

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Section: The Oct Family Of Transcription Factorsmentioning

confidence: 99%

The role of octamer binding transcription factors in glioblastoma multiforme

Rooj

Bronisz

Godlewski

2016

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

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“…Previous studies have described Oct4 expression in different human neuroblastic cell lines and side-population cells in NBTs, linking its presence with the stem cell-like phenotype in these tumours [23–25]. The characteristic phenotype implies a stem cell self-renewal capacity, but also the presence of tumour cells with multipotential differentiation properties that can be induced to differentiate in neuroblastic or glial phenotypes.…”

Section: Introductionmentioning

confidence: 98%

High Oct4 expression: implications in the pathogenesis of neuroblastic tumours

Monferrer¹,

et al. 2019

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BackgroundNeuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for tumour progression, chemotherapy resistance and recurrence in NBTs. Oct4 is a transcription factor which plays a key role in mammal embryonic development and stem cell fate regulation. The aim of the study is to elucidate the clinical significance of Oct4 in NBTs.MethodsWe studied Oct4 expression in 563 primary NBTs using digital image quantification. Chi-square test was applied to analyse the correlation between histopathology and the Oct4+ cell percentage. Survival analysis was carried out with Kaplan-Meier curves and log-rank test. Additionally, a multivariate Cox regression analysis with the stepwise backwards (Wald) method was undertaken to calculate the impact of Oct4 expression level on survival.ResultsWe found that tumours with a high proportion of cells expressing Oct4 correlated statistically with undifferentiated and poorly differentiated neuroblastoma / nodular ganglioneuroblastoma, and that Oct4 expression was not present in ganglioneuroma (p < 0.05). Statistical analysis also indicated a relationship between high Oct4 expression levels, high-risk patients according to the International Neuroblastoma Risk Group pre-treatment classification parameters, larger blood vessels and low survival rates.ConclusionsThese results suggest that the Oct4 gene may regulate NBT pathogenic differentiation pathways, and should thus be considered as a target for knockdown when developing novel therapies for high-risk NBT patients.

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“…The overexpression of POU5F1 in BE(2)-C human NB type I cells can promote cell proliferation and increase its colony formation rate [ 29 ]. There are many mechanisms for Pou5f1 to regulate the cell cycle.…”

Section: The Target Genes Of N-mycmentioning

confidence: 99%

A Review of the Regulatory Mechanisms of N-Myc on Cell Cycle

Dong

Jin

et al. 2023

Molecules

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Neuroblastoma has obvious heterogeneity. It is one of the few undifferentiated malignant tumors that can spontaneously degenerate into completely benign tumors. However, for its high-risk type, even with various intensive treatment options, the prognosis is still unsatisfactory. At the same time, a large number of research data show that the abnormal amplification and high-level expression of the MYCN gene are positively correlated with the malignant progression, poor prognosis, and mortality of neuroblastoma. In this context, this article explores the role of the N-Myc, MYCN gene expression product on its target genes related to the cell cycle and reveals its regulatory network in promoting tumor proliferation and malignant progression. We hope it can provide ideas and direction for the research and development of drugs targeting N-Myc and its downstream target genes.

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Downregulation of OCT4 promotes differentiation and inhibits growth of BE (2)-C human neuroblastoma I-type cells

Cited by 5 publications

References 26 publications

The role of octamer binding transcription factors in glioblastoma multiforme

The role of octamer binding transcription factors in glioblastoma multiforme

High Oct4 expression: implications in the pathogenesis of neuroblastic tumours

A Review of the Regulatory Mechanisms of N-Myc on Cell Cycle

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