Downregulation of miR‐138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines

Mitomo, Shingo; Maesawa, Chihaya; Ogasawara, Satoshi; Iwaya, Takeshi; Shibazaki, Masahiko; Yashima-Abo, Akiko; Kotani, Koji; Oikawa, Hiroki; Sakurai, Eiich; Izutsu, Naoko; Kato, Kuniyuki; Komatsu, Hideaki; Ikeda, Kenichro; Wakabayashi, Go; Masuda, Tomoyuki

doi:10.1111/j.1349-7006.2007.00666.x

Cited by 238 publications

(213 citation statements)

References 42 publications

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“…Of the 55 putative targets, we found that only eight have been empirically validated: miR-378-SUFU, miR-101- MYCN,, and let-7c-TRIM71 (Lewis et al 2003(Lewis et al , 2005Yekta et al 2004;Lee et al 2007;Lin et al 2007;Mitomo et al 2008). Interestingly, many of the 47 remaining putative targets have known CSR functions: proteolysis (miR-101-UBE2A); molecular chaperones (miR-125b-DNAJB2, miR-424-HSPA4L, miR-424-DNAJB4, miR-125b-TTC7A, miR-452-TTC7A, miR-378-TTC7A, miR-378-HSP90AB1, miR-138-CCT5, miR-138-HSPA4L, miR-376a-HSPA6, miR-let-7c-HSPB2, and miR-196a-HSPH1) (Kojima et al 2004;White et al 2005); protein trafficking (miR-125-ZFYVE1); metabolism (miR-382-KYNU, miR-378-KLK4, miR-376a-MAN1C1, miR-let-7c-GALE, and miR-let-7c-RNF20); cell cycle progression (miR-101-MYCN, miR-196a-HOXC8, and miR-196b-HOXC8) (Deraison et al 2007;Kamel et al 2009) (Tables 1 and 2).…”

Section: Resultsmentioning

confidence: 99%

Identification of microRNAs associated with hyperthermia-induced cellular stress response

Wilmink

Roth

Ibey

et al. 2010

Cell Stress and Chaperones

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MicroRNAs (miRNAs) are a class of small RNAs that play a critical role in the coordination of fundamental cellular processes. Recent studies suggest that miRNAs participate in the cellular stress response (CSR), but their specific involvement remains unclear. In this study, we identify a group of thermally regulated miRNAs (TRMs) that are associated with the CSR. Using miRNA microarrays, we show that dermal fibroblasts differentially express 123 miRNAs when exposed to hyperthermia. Interestingly, only 27 of these miRNAs are annotated in the current Sanger registry. We validated the expression of the annotated miRNAs using qPCR techniques, and we found that the qPCR and microarray data was in well agreement. Computational target-prediction studies revealed that putative targets for the TRMs are heat shock proteins and Argonaute-2-the core functional unit of RNA silencing. These results indicate that cells express a specific group of miRNAs when exposed to hyperthermia, and these miRNAs may function in the regulation of the CSR. Future studies will be conducted to determine if other cells lines differentially express these miRNAs when exposed to hyperthermia.

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Section: Resultsmentioning

confidence: 99%

Identification of microRNAs associated with hyperthermia-induced cellular stress response

Wilmink

Roth

Ibey

et al. 2010

Cell Stress and Chaperones

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“…miR-146a was identified as a common target of Krüppel-like factor 8 (KLF8) and TGFb, both of which are known EMT-inducers in breast cancer cell line (Wang et al 2013). miR-21 was upregulated in human ATC cell lines (Mitomo et al 2008) by oncogenic Ras (Frezzetti et al 2011). PTCs with high expression of miR-21 had significantly poorer disease-free survival rates and higher LN metastasis by in situ hybridization .…”

Section: Downregulation Of Specific Micrornasmentioning

confidence: 97%

“…c-MET, a proto-oncogene that encodes hepatocyte growth factor (HGF) receptor, was identified as a potential target gene for miR-34b and miR-1, and significantly higher level of c-MET expression was observed in aggressive PTCs (Yip et al 2011). Downregulation of miR-138 was associated with overexpression of human telomerase reverse transcriptase protein in human ATC cell lines (Mitomo et al 2008). Using a squamous cell carcinoma model, it was reported that miR-138 regulated EMT by targeting multiple components of the EMT pathways, such as ZEB2 and the epigenetic regulator EZH2.…”

Section: Downregulation Of Specific Micrornasmentioning

confidence: 99%

“…Upregulation of specific microRNAs miR-221/-222 are upregulated in human ATC cell lines (Mitomo et al 2008), PTCs (Pallante et al 2006), minimally invasive FTC with distant metastasis, and widely invasive FTC (Jikuzono et al 2013). miR-221/ -222-upregulated carcinomas show dramatic loss of KIT transcript and KIT protein (He et al 2005).…”

Section: Downregulation Of Specific Micrornasmentioning

confidence: 99%

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Cancer stem-like cells and thyroid cancer

Guo¹,

Hardin²,

Lloyd³

2014

Endocrine Related Cancer

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Thyroid cancer is one of the most rapidly increasing malignancies. The reasons for this increase is not completely known, but increases in the diagnosis of papillary thyroid microcarcinomas and follicular variant of papillary thyroid carcinomas along with the enhanced detection of well-differentiated thyroid carcinomas are probably all contributing factors. Although most cases of well-differentiated thyroid carcinomas are associated with an excellent prognosis, a small percentage of patients with well-differentiated thyroid carcinomas as well as most patients with poorly differentiated and anaplastic thyroid carcinomas have recurrent and/or metastatic disease that is often fatal. The cancer stem-like cell (CSC) model suggests that a small number of cells within a cancer, known as CSCs, are responsible for resistance to chemotherapy and radiation therapy, as well as for recurrent and metastatic disease. This review discusses current studies about thyroid CSCs, the processes of epithelial-to-mesenchymal transition (EMT), and mesenchymal-to-epithelial transition that provide plasticity to CSC growth, in addition to the role of microRNAs in CSC development and regulation. Understanding the biology of CSCs, EMT and the metastatic cascade should lead to the design of more rational targeted therapies for highly aggressive and fatal thyroid cancers.

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“…Another study (Mitomo et al 2008) revealed that miR-21, -146b, -221, and -222 were overexpressed in ATCs (Table 2). Among the downregulated miRs were found miR-26a, -138, -219, and -345.…”

Section: Mir Expression In Ftcsmentioning

confidence: 99%

Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas

Pallante¹,

Visone²,

Croce³

et al. 2010

Endocrine-Related Cancer

114

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Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms.

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Downregulation of miR‐138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines

Cited by 238 publications

References 42 publications

Identification of microRNAs associated with hyperthermia-induced cellular stress response

Identification of microRNAs associated with hyperthermia-induced cellular stress response

Cancer stem-like cells and thyroid cancer

Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas

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