Downregulation of circular RNA circ-LDLRAD3 suppresses pancreatic cancer progression through miR-137-3p/PTN axis

<p>Circular RNA ZNF609 Promoted Hepatocellular Carcinoma Progression by Upregulating PAP2C Expression via Sponging miR-342-3p</p>

“…8 Circ-LDLRAD3 knockdown inhibited pancreatic cancer by interacting with miR-137-3p and modulating PTN. 9 In this study, we found that circular RNA ZNF609 (circZNF609) was upregulated and induced oncogenic phenotypes in HCC. A common way for circRNAs to function is to sponge miRNAs, thereby upregulating downstream target genes.…”

Non-coding RNAs in Pancreatic Ductal Adenocarcinoma

“…In addition, overexpression of ciRS7 promotes lymph node metastasis and venous invasion in PDAC cases. Down-regulation of circ-LDLRAD3 can inhibit PDAC cell proliferation and metastasis through the up-regulation of miR-137-3p/ PTEN (80). Others have proven that the circRHOT1 regulates the PDAC cells proliferation, invasion and metastasis by binding to miRNAs, including miR-26b, miR-125a, miR-330, and miR-382 (83).…”

Current State of “Omics” Biomarkers in Pancreatic Cancer

“…Successfully accomplishing multi-omics data integration by systems biology approaches will fulfill future expectations and the need for robust, accurate, and feasible biomarker panels for pancreatic cancer. [166] Tumor tissue hsa_circ_0006215 Upregulated circRNA overexpression [167] Tumor tissue, plasma exosome circ-IARS Upregulated circRNA overexpression [168] Tumor tissue circ-PDE8A Upregulated circRNA overexpression [169] Tumor tissue/cell hsa_circ_0001649 Downregulated Microarray/qRT-PCR [170] Tumor tissue/cell hsa_circ_0005397 (circ-RHOT1) Upregulated Microarray/qRT-PCR [171] Tumor tissue/cell lines hsa_circ_0030235 Upregulated circRNA overexpression [172] Tumor tissue/cell lines hsa_circ_0007534 Upregulated circRNA overexpression [173] Tumor tissue/cell lines ciRS-7 (Cdr1as) Upregulated qRT-PCR [174] Tumor tissue hsa_circ_0007334 Upregulated Microarray/qRT-PCR [175] Tumor tissue circLDLRAD3 Upregulated circRNA knockdown [176] Tumor tissue/cell circASH2L Upregulated Microarray/qRT-PCR [177] Tumor tissue/cell lines circADAM9 Upregulated circRNA knockdown [178] Tumor tissue/cell hsa_circ_001653 Upregulated circRNA knockdown [179] Tumor tissue/cell circHIPK3 Upregulated circRNA knockdown [180] Tumor tissue/cell circFOXK2 Upregulated circRNA knockdown [181] Tumor tissue hsa_circ_0009065 (circBFAR) Upregulated circRNA overexpression [70] Tumor tissue hsa_circ_0086375 (circNFIB1) Downregulated circRNA knockdown [182] Tumor tissue/cell hsa_circ_0013912 Upregulated circRNA overexpression [183] Tumor tissue/cell lines hsa_circ_001587 Downregulated circRNA knockdown [184] Tumor [194] Tumor tissue BC008363 Upregulated Microarray/qRT-PCR [195] Tumor tissue HSATII Upregulated RNA-seq [196] Serum/plasma U2snRNA Upregulated Microarray/qRT-PCR [197] Pancreatic * CZE: capillary zone electrophoresis, ELISA: enzyme-linked immunosorbent assay, ELLA: Enzyme-linked lectin assay, FISH: fluorescence in situ hybridization, GC: gas chromatography, HILIC: Hydrophilic interaction chromatography, HRMAS: high-resolution magic angle spinning, LC: liquid chromatography, MS: mass spectrometry, NMR: nuclear magnetic resonance, qRT-PCR: quantitative reverse transcription polymerase chain reaction, TOF: time of flight, WB: Western blot, WES: Whole exome sequencing, WGS: whole genome ...…”