Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis

Jian-guo, Liu; Zhang, Zhe; Gao, Jiechang; Xie, Jiwen; Yang, Lin; Hu, Shenjun

doi:10.1007/s11684-011-0111-4

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…β‐elemene was also found to exhibit anti‐inflammatory activities in various systems, as indicated by its ability to downregulate IL‐17 and IFN‐γ in experimental autoimmune encephalomyelitis and by acting as an anti‐ulcer agent in gastric ulcer models of rodents . β‐elemene was also found to downregulate serum TNF‐α levels and hepatic CD14 expression in rats with liver fibrosis . Thus these studies clearly demonstrate that β‐elemene exhibits both anti‐inflammatory and anticancer activities.…”

Section: Anti‐inflammatory and Anticancer Activities Of Noncurcumin Cmentioning

confidence: 64%

Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric

Aggarwal

Wei

et al. 2013

Molecular Nutrition Food Res

265

167

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Turmeric, a dried powder derived from the rhizome of Curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic, antimicrobial, wound healing, and memory-enhancing activities. One component of turmeric is curcumin, which has been extensively studied, as indicated by more than 5600 citations, most of which have appeared within the past decade. Recent research has identified numerous chemical entities from turmeric other than curcumin. It is unclear whether all of the activities ascribed to turmeric are due to curcumin or whether other compounds in turmeric can manifest these activities uniquely, additively, or synergistically with curcumin. However, studies have indicated that turmeric oil, present in turmeric, can enhance the bioavailability of curcumin. Studies over the past decade have indicated that curcumin-free turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities. Elemene derived from turmeric is approved in China for the treatment of cancer. The current review focuses on the anticancer and anti-inflammatory activities exhibited by CFT and by some individual components of turmeric, including turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrone.

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Section: Anti‐inflammatory and Anticancer Activities Of Noncurcumin Cmentioning

confidence: 64%

Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric

Aggarwal

Wei

et al. 2013

Molecular Nutrition Food Res

265

167

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“…Furthermore, β-elemene can downregulate the levels of plasma endotoxins, serum TNF-α, and CD14 expression in hepatic fibrosis rats. β-elemene may play an important role in liver tumorigenesis [27]. …”

Section: Resultsmentioning

confidence: 99%

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells

Dai

Tang

et al. 2013

Cancer Cell Int

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Backgroundβ-elemene, a natural sesquiterpene extracted from the essential oils of Curcuma aromatica Salisb, has been shown to be effective against a wide range of tumors. In this study, the antitumor effect of β-elemene on a human hepatoma cell line, HepG2, and the mechanism involved have been investigated.MethodsMTT assay was used to determine the growth inhibition of hepatoma HepG2 cells in vitro. Apoptosis of HepG2 cells were demonstrated by fluorescence microscope with Hoechst 33258 staining and flow cytometry with Annexin V-FITC/PI double staining. Flow cytometry was performed to analyze the cell cycle distribution of HepG2 cells. The mRNA and protein expression of Fas and FasL were measured by RT-PCR and Western blot analysis.ResultsMTT results showed that β-elemene could inhibit the proliferation of HepG2 cells in a time- and dose- dependent manner. Our results showed β-elemene had positive effect on apoptosis through fluorescence microscope and flow cytometry assay. Furthermore, β-elemene could induce the cell cycle arrest of the HepG2 cells in the G2/M phase. Fas and FasL expression were obviously increased after β-elemene treatment in both mRNA and protein level.ConclusionThe present study indicates that β-elemene can effectively inhibit proliferation and induce apoptosis in hepatoma HepG2 cells, and the apoptosis induction is related with up-regulating of Fas/FasL expression.

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“…Currently, the traditional Chinese medicine β-elemene is widely used in the complementary treatment of different types of malignancies [20,21,22,23,24,25,26,27]. β-Elemene has also been found to inhibit the expression of angiotensin II and RhoA/ROCK signaling in hepatic stellate cells and to delay the progression of hepatic fibrosis [28,29,30,31,32]. It may also be effective in antiosteogenic differentiation of ankylosing spondylitis fibroblasts by inhibiting the BMP/SMAD signal pathway and subsequently blocking the expression of ossification marker genes RUNX2 that initiate osteogenic differentiation [33].…”

Section: Discussionmentioning

confidence: 99%

“…It has also been shown to reverse multidrug resistance [20,21,22,23,24,25,26,27]. In addition, research has shown that β-elemene can inhibit proliferation of human bone fibroblasts and lens epithelial cells and that it can inhibit liver fibrosis [28,29,30,31,32,33,34]. …”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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Background: Recurrent airway granulation hyperplasia and scar formation make airway stenosis a clinical challenge. Therefore, a new approach for the treatment of airway stenosis is necessary. Objective: To explore the inhibitory effect of β-elemene on the proliferation of fibroblasts and airway granulation. Methods: In vivo: (1) study of the effect of local β-elemene injection by bronchoscopy. (2) During bronchoscopy, granulation tissues both before and after treatment were obtained. HE staining was performed and the result compared. In vitro: (1) human airway primary fibroblasts were purified and characterized. (2) Fibroblasts were treated with β-elemene and normal saline (NS) and then examined by optical and electron microscopy. (3) Fibroblasts treated with β-elemene or NS were assessed for viability by tetrazolium salt assay. (4) Apoptotic rates were determined by flow cytometry. Results: In vivo: (1) after local injection of β- elemene, airway granulation tissue was reduced. (2) Granulation tissue was found to have less edema, and fibroblasts turned into mature fiber cells. In vitro: (1) human airway primary fibroblasts were successfully purified and cultured. (2) Compared with the control group, fibroblasts of the experimental group became clumped, the plasma granules were increased, and some fibroblasts lost their nucleus and organelles. (3) Compared with the control group, reduction of cell viability was detected with increased concentrations of β-elemene. (4) With increased concentrations of β-elemene, apoptotic rates of the fibroblasts were raised compared with the control group. Conclusions: β-Elemene may induce apoptosis and necrosis of airway primary fibroblasts and inhibit the proliferation of fibroblasts and airway granulation. The results provide a new approach for the treatment of airway stenosis.

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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic CD14 expression in rats with liver fibrosis

Cited by 23 publications

References 23 publications

Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric

Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

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