Downregulating NF-κB signaling pathway with triterpenoids for attenuating inflammation:in vitroandin vivostudies

Abstract

Two triterpenoids from Acanthopanax trifoliatus, an edible medicinal plant from Southeast Asia, attenuated lipopolysaccharides-induced inflammation in murine macrophage RAW246.7 cells and tetradecanoylphorbolacetate-induced mouse ear edema.

Jasmine (Jasminum grandiflorum) Flower Extracts Ameliorate Tetradecanoylphorbol Acetate Induced Ear Edema in Mice

“…Hematoxylin and eosin staining assay was performed on mice ear tissues that were fixed in paraffin and sectioned into 4-µm sections using method previously reported. 8 Immunohistochemical staining assays were performed on mice ear tissue sections as we previously reported. 8 Sectioned tissues were incubated with antimouse monoclonal antibodies including COX-2 and IκB, followed by appropriated secondary antibodies.…”

“…8 Immunohistochemical staining assays were performed on mice ear tissue sections as we previously reported. 8 Sectioned tissues were incubated with antimouse monoclonal antibodies including COX-2 and IκB, followed by appropriated secondary antibodies. Randomly selected visual fields (n = 10; at 400× magnification) in each group are recorded using a microscopy (AxioScope A1, ZEISS, Germany), and the amount of COX-2 and IκB positive cells were counted with microscopy.…”

“…During the course of bioactivity screening using a panel of in-house bioassays, several plant extracts (including jasmine flower extracts [JFEs]) showed promising anti-inflammatory effects in cellular based assays and in animal models. 8 To further investigate the anti-inflammatory property of jasmine extracts as well as their skin protective effects, 4 JFEs were evaluated for the anti-skininflammatory effect in a mouse model. Herein, the ameliorative effects of JFEs against tetradecanoylphorbol acetate (TPA)-induced ear skin inflammation are reported.…”

The complete chloroplast genome sequence of Acanthopanax trifoliatus (Linn.) Merr.

“…It is commonly cultivated in China, India, Thailand, Vietnam, and the Philippines. Leaves of A. trifoliatus are popularly consumed as vegetables and herbal tea in southern China (Chen et al 2019). Traditionally, A. trifoliatus has also been used as folk medicine to treat various diseases, including lung hemorrhages, bruises, ulcers, and partial (Sithisarn et al 2009).…”

“…Traditionally, A. trifoliatus has also been used as folk medicine to treat various diseases, including lung hemorrhages, bruises, ulcers, and partial (Sithisarn et al 2009). Pharmacological studies also reported that A. trifoliatus extracts showed numerous biological activities, including antioxidative, anti-inflammatory, anti-cancer, and neuroprotective effects (Chen et al 2019). The sequencing of the chloroplast genome of medicinal plants will promote indepth research on the chloroplast genome of medicinal plants and the development of related industries.…”