Antibacterial, anti‐inflammatory, analgesic, and hemostatic activities of Acanthopanax trifoliatus (L.) merr

Abstract

Acanthopanax trifoliatus (L.) Merr (AT) is a medicinal and edible plant with high nutritional value. The biological activity of A. trifoliatus (L.) Merr and its basis for injury treatment are explored in this paper. AT was ethanol‐extracted then refined separately with petroleum ether, chloroform, ethyl acetate, and n‐butanol. Active ingredients were analyzed, and anti‐bacterial, anti‐inflammatory, analgesic, and hemostatic effects were explored. Petroleum ether layer (PEL) extract produced the strongest antibacterial effect. Ethyl acetate layer (EAL) extract had the highest active substance content, with strong hemostatic and analgesic activities. Chloroform layer (CL) extract had the strongest anti‐inflammatory effect and significantly reduced IL‐1β protein expression. Active ingredients were analyzed using HPLC and UPLC‐MS to determine saponin, polyphenol, flavonoid, and characteristic ingredient contents. EAL extract had the highest polyphenol and flavonoid levels, including rutin, chlorogenic acid, isochlorogenic acid A, and isochlorogenic acid C, which may contribute to its nutritional activities. The study provides a reliable theoretical and practical basis for the applications of AT nutraceutical products.

Dynamic changes in marker components during the stir-frying of Pharbitidis Semen, and network analysis of its potential effects on nephritis

“…With an increase in 5-CQA concentration, the inhibition rate of the inflammatory factor IL-6 increased correspondingly ( Gao et al, 2020 ). Acanthopanax senticosus extract contains 3-CQA, 3,5-DiCQA, and 4,5-DiCQA, which have strong anti-inflammatory effects ( Chen et al, 2021 ). 4-CQA exerts anti-inflammatory effects by reducing oxidative stress during the inflammatory response ( Zhao et al, 2020 ).…”

Study on the Fingerprints of Acanthopanax trifoliatus Fractions with Varying Polarities and the Relationship Between Anti-inflammatory and Antioxidant Activity Using Multivariate Analysis

“…Numerous studies have shown that ATRB has good anti-inflammatory and antioxidant effects. Researchers found that treatment with the water extract of ATRB can prolong the exhaustive exercise time of rats with chronic swimming stress, and 10 phenolic acids were isolated and identified from the water extract, among which chlorogenic acid and (+)-syringaresinol-di-O-beta-D-glucoside were the main components (Chen et al, 2021; Wang et al, 2015; Xiao et al, 2011). The main effective components of ATRB are phenolic acids (Wang et al, 2018).…”

Exploring the Effects of Solid-State Fermentation on Polyphenols in Acanthopanax senticosus Based on Response Surface Methodology and Nontargeted Metabolomics Techniques

“…It can work to strengthen the body and mind and has the efcacy of nourishing Qi, strengthening the spleen, nourishing the kidney, and soothing the nerves [3]. Te primary chemical constituents of A. senticosus include polyphenols [4], polysaccharides [5], glycosides [6], and lignans, which have good pharmacological activities to regulating immune function [7], antifatigue efect [8], antioxidant activity [9], and anti-infammatory properties [10]. Polyphenols are secondary plant metabolites found in traditional Chinese medicine with potential efects on health and are also the general term for plant components with several phenolic hydroxyl groups in the molecular structure, including polyphenols, tannins, phenolic acids, and anthocyanins [11].…”