Nasogastric tubes are routinely inserted in clinical practice, followed by rare though possibly serious and life-threatening complications.Objective: To review the management of esophageal injury as a result of nasogastric tube insertion, we report the case of a 78-year-old critically ill male, who suffered massive subcutaneous emphysema as a result of inadvertent nasogastric tube insertion. Computed tomography and simple radiography confirmed nasogastric tube misplacement and left-side cervical esophageal perforation, which was surgically repaired.Results: This report outlines that even though the nasogastric tube placement technique is apparently simple, major complications, such as esophageal perforation, may occur. The risk increases in cases of difficult nasogastric tube insertion, where, even though several techniques are described, there is no consensus for a standard approach. Overall, early diagnosis is crucial and a multidisciplinary approach is essential to successfully manage the injury, thus reducing patients' morbidity and mortality.