1995
DOI: 10.1073/pnas.92.20.9191
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Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development.

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Cited by 86 publications
(41 citation statements)
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References 24 publications
(29 reference statements)
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“…These zones of expression include the longitudinal basal plate of the diencephalon (Sim1 and Sim2), the mesencephalon (Sim1), the zona limitans intrathalamica (Sim1 and Sim2) and the portion of the spinal cord that flanks the floor plate (Sim1) (Ema et al, 1996a;Ema et al, 1996b;Fan et al, 1996). Sim2 maps to the region responsible for Down Syndrome (DS) on Chromosome 21 (Chrast et al, 1997;Dahmane et al, 1995;Muenke et al, 1995). Interestingly, Sim2 is also expressed in non-neuronal tissues, including branchial arches and the developing limb, which are primordia of tissues and organs where DS abnormalities are frequently observed (Rachidi et al, 2005).…”
Section: Research Articlementioning
confidence: 99%
“…These zones of expression include the longitudinal basal plate of the diencephalon (Sim1 and Sim2), the mesencephalon (Sim1), the zona limitans intrathalamica (Sim1 and Sim2) and the portion of the spinal cord that flanks the floor plate (Sim1) (Ema et al, 1996a;Ema et al, 1996b;Fan et al, 1996). Sim2 maps to the region responsible for Down Syndrome (DS) on Chromosome 21 (Chrast et al, 1997;Dahmane et al, 1995;Muenke et al, 1995). Interestingly, Sim2 is also expressed in non-neuronal tissues, including branchial arches and the developing limb, which are primordia of tissues and organs where DS abnormalities are frequently observed (Rachidi et al, 2005).…”
Section: Research Articlementioning
confidence: 99%
“…Sim1 maps on mouse chromosome 10 and Sim2 on mouse chromosome 16 in a region of synteny with HC21 (Fan et al 1996). Both mouse Sim1 and Sim2 genes are expressed early [Sim2 from embryonic day 8.0 (E8.0) and Sim1 from E9.0] in developing forebrain (Ema et al 1996b;Fan et al 1996;Moffett et al 1996;Yamaki et al 1996) and outside the central nervous system (CNS), in somites, mesonephric duct, and foregut (Sim1), in facial and trunk cartilage, trunk muscles (Sim2), and in the developing kidney (Sim1 and Sim2) (Dahmane et al 1995;Ema et al 1996b;Fan et al 1996;Moffett et al 1996). In adult mouse, both Sim1 and Sim2 are expressed in kidney and skeletal muscles, whereas Sim2 is also expressed in the lung (Ema et al 1996a,b;Moffett et al 1996).…”
mentioning
confidence: 99%
“…Despite their seemingly different transcriptional roles, the expression patterns of murine Sim genes during development are reminiscent of those of the Drosophila sim (Dahmane 1995;Ema et al 1996;Fan et al 1996;Yamaki et al 1996). For example, Figure 1 shows that the Drosophila sim transcript and protein are detected in the CNS midline cells located in the ventral body wall.…”
mentioning
confidence: 97%
“…Several laboratories have characterized and cloned the DSCR. Using the exon-trapping technique to isolate potential coding sequences within this region, two groups have identified exons that predict an open reading frame that is highly homologous to the Drosophila sim gene product (Chen et al 1995;Dahmane et al 1995). In parallel, two murine homologs of sim have been cloned and named Sim1 and Sim2 (Ema et al 1996;Fan et al 1996;Moffett et al 1996;Yamaki et al 1996).…”
mentioning
confidence: 99%