1997
DOI: 10.1101/gr.7.6.569
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Single-minded—Two Genes, Three Chromosomes : Figure 1.

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Cited by 13 publications
(10 citation statements)
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“…Sim1 is essential for the development of the PVN and SON (24). Sim1 Ϫ/Ϫ mice die perinatally, presumably due to the lack of PVN and SON.…”
Section: Sim2 Mutant Displays No Additive Phenotype In the Sim1mentioning
confidence: 99%
“…Sim1 is essential for the development of the PVN and SON (24). Sim1 Ϫ/Ϫ mice die perinatally, presumably due to the lack of PVN and SON.…”
Section: Sim2 Mutant Displays No Additive Phenotype In the Sim1mentioning
confidence: 99%
“…Two mammalian sim orthologs (Sim1 and Sim2) have been discovered that share a number of functional similarities with Drosophila sim (for review, see Michaud and Fan 1997). Both Sim1 and Sim2 proteins dimerize with mammalian Arnt and bind the CME in vitro (Ema et al 1997a;Probst et al 1997).…”
Section: Mammalian Sim and Down Syndromementioning
confidence: 99%
“…The Sim genes are expressed early in brain development suggesting that they might play roles in neurogenesis analogous to Drosophila sim. The roles of Sim1 and Sim2 in embryonic development should be soon forthcoming since both genes have been knocked out in mice (Michaud and Fan 1997). One other distinction is that cell culture transfection experiments suggest that both mammalian Sim proteins function as transcriptional repressors (Ema et al 1997a;Moffett et al 1997).…”
Section: Mammalian Sim and Down Syndromementioning
confidence: 99%
“…SIM2 can heterodimerize with aryl hydrocarbon receptor nuclear translocator (ARNT) and translocate to the nucleus to transcriptionally regulate gene expression [3]. Expression of SIM2 mRNA has been detected in fetal brain regions associated with DS pathology [4].…”
Section: Introductionmentioning
confidence: 99%