Down syndrome biochemical markers and screening for preeclampsia at first and second trimester: correlation with the week of onset and the severity

Kang, Jung Hoon; Farina, Antonio; Park, Ji‐Hyeon; Kim, Sung-Han; Kim, Ji Yeon; Rizzo, Nicola; Elmakky, Amira; Jun, Hey Jung; Hahn, Won Bo; Hyun, Dong

doi:10.1002/pd.1997

Cited by 58 publications

(42 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several other studies have also confirmed these finding [2,3,11]. However Kang, Wald and Davidson did not find any significant increase in AFP in those that developed pre-eclampsia compared to controls [15][16][17].…”

Section: Introductionsupporting

confidence: 67%

The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome

Allen¹,

Marleen²,

Velauthar³

et al. 2013

OJOG

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 67%

The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome

Allen¹,

Marleen²,

Velauthar³

et al. 2013

OJOG

View full text Add to dashboard Cite

“…The most effective thresholds were 2.0 multiples of the median (MoM) for alpha-fetoprotein (AFP) resulting in a positive likelihood ratio (LR) of 2.36 and a negative likelihood ratio of 0.96 [15]. On the other hand Davidson, Kang and Wald did not find any significant increase in MSAFP levels in preeclamptic women [8,16,17]. We found no significant difference in the rate of preeclampsia between the groups.…”

Section: Discussionmentioning

confidence: 57%

Is unexplained elevated maternal serum alpha-fetoprotein still important predictor for adverse pregnancy outcome?

Başbuğ

Gülerman

2017

Ginekol Pol

View full text Add to dashboard Cite

Objectives: The purpose of this study was to determined the predictive value of maternal serum alpha-fetoprotein (MSAFP) as a marker for adverse pregnancy outcomes. Material and methods:This study was carried out at Dr. Zekai Tahir Burak Women's Health Education and Research Hospital between 2009 and 2010. This study included a total of 1,177 pregnant women, including 170 in the study group and 1,007 in the control group. Pregnancy outcomes and characteristics were analyzed with regard to the MSAFP value.Results: Gestational week, birth weight and APGAR scores were significantly lower in the elevated MSAFP group (p < 0.001). Adverse pregnancy outcomes, such as preterm delivery, preterm premature rupture of membranes (PPROM), oligohydramnios and intrauterine growth restriction (IUGR) rates were increased in the elevated MSAFP group. Conclusions:Although ultrasound outweighs as a screening method for neural tube defects and non-invasive prenatal testing outweighs for aneuploidy screening MSAFP level in the second trimester is still an important predictor for poor maternal/fetal outcomes.

show abstract

“…Inhibin A participates in the regulation of cell growth and differentiation in the placenta, and levels of maternal serum alpha-fetoprotein (MSAFP), maternal serum human chorionic gonadotrophin (hCG), and low uE 3 are associated with placental permeability and placentation. Despite many studies on the relationships between serum markers and preeclampsia, these markers have not achieved sufficient predictive value to be used alone for the screening of preeclampsia [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Early Detection of Preeclampsia Using Inhibin A and Other Second-Trimester Serum Markers

Ree¹,

Hahn²,

Chang³

et al. 2011

Fetal Diagn Ther

Self Cite

View full text Add to dashboard Cite

Objective: The purpose of this study was to determine whether second-trimester maternal serum markers including inhibin A are useful for the detection of preeclampsia. Methods: Between January 2005 and March 2009, we analyzed the data of 4,764 subjects who underwent second-trimester multiple-marker screening for Down syndrome. Serum samples were assayed at 15+0 to 20+6 weeks for maternal serum alpha-fetoprotein (MSAFP), human chorionic gonadotrophin (hCG), unconjugated estriol (uE₃) and inhibin A. We reviewed all medical records retrospectively, and assessed the relationships of several markers with preeclampsia using logistic regression analysis. Results: The study sample included 41 patients who developed preeclampsia and a control group consisting of the other 4,723 healthy subjects treated between January 2005 and March 2009. There were no significant differences in gestational ages at blood sampling, maternal weights, gravidity and parity between the two groups. However, the mean ages, Apgar scores, gestational age at delivery and neonatal weights were significantly different between the study group and the control group. The levels of markers in the study group were significantly increased compared to the control group, 1.76 ± 2.68 for inhibin A, 1.18 ± 0.69 for MSAFP, and 1.62 ± 1.18 for hCG, but uE₃ did not differ significantly between the two groups. The AUC of inhibin A was 0.715, but the AUC of a three-marker combination model (0.800) was even better. A mid-trimester inhibin A concentration of 1.5 MoM or greater had a sensitivity of 60% and a false-positive rate of 16% for the prediction of preeclampsia. Inhibin A was the best predictor of preeclampsia. Three other markers were reliable predictive markers of preeclampsia. Conclusions: Inhibin A and other second-trimester serum markers may be useful for early detection of preeclampsia. Inhibin A was in fact the most important predictable marker among the markers we surveyed. The results of this study support those of previous studies, and provide quantified data elucidating the occurrence of preeclampsia.

show abstract

Down syndrome biochemical markers and screening for preeclampsia at first and second trimester: correlation with the week of onset and the severity

Cited by 58 publications

References 37 publications

The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome

The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome

Is unexplained elevated maternal serum alpha-fetoprotein still important predictor for adverse pregnancy outcome?

Early Detection of Preeclampsia Using Inhibin A and Other Second-Trimester Serum Markers

Contact Info

Product

Resources

About