Down-regulation of S-phase kinase associated protein 2 (Skp2) induces apoptosis in oral cancer cells

Up-Regulation of S-Phase Kinase Associated Protein-2 Antisense Induces Cell Growth and Migration Chemotactic Suppression and Apoptosis in a Malignant Oral Burkitt's Lymphoma Cells

“…Also, in the current study, increased caspase-3 and -9 activation in As-treated cells revealed that apoptosis ensued extrinsic and intrinsic pathways. Similar results were reported by Harada et al 22) who suggested that in oral cancer, induction of apoptosis can be caused by down-regulation of Skp2 (or up-regulation of Skp2 AS) .…”

“…It has been reported that AS oligonucleotides hybridized to the complementary target mRNA and caused a steric or conformational obstacle for protein translation. As a result, the production of a spesific protein is temporarily inhibited without affecting the expression of other genes and without 22) reported that the mechanism of action of AS oligonucleotide can be discerned through the Rnase H-dependent oligonucleotide. These appear to induce the degradation of mRNA and the steric-blocker oligonucleotides, which physically prevent or inhibit the progression of splicing or the translational machinery.…”

Synthesis and Positive Inotropic Evaluation of 2‐(4‐(4‐Substituted benzyloxy)‐3‐methoxybenzyl)‐1,4‐diazepan‐1‐yl)‐N‐(4,5‐dihydro‐1‐methyl[1,2,4]triazolo[4,3‐a]quinolin‐7‐yl)‐acetamides

“…In conclusion, based on the structure of PHR9612, we synthesized 2-(4-(4-substitutedbenzyloxy) -3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-methyl [1,2,4]triazolo [4,3-a]quinolin-7-yl)acetamides and tried to find more potent compounds for cardiac contractility without increasing the heart rate. As a result, we obtained several compounds having enhanced inotropic effects and desirable biological profiles in our present study, in which compounds 6e and 6f exhibited more promising cardiovascular profiles.…”

“…Nonetheless, the significant ventricular arrhythmias and tachycardia associated with the elevated cAMP level also limit the clinical use of milrinone [2]. Similar cases were found in the recently developed vesnarinone [3,4] and toborinone [5]. These cardiotonic agents ultimately exert their inotropic effects via an increase in intracellular calcium and consequently possess strong arrhythmogenic effects that caused increased mortality when used in CHF patients.…”

SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis

“…However, recent evidence revealed that SKP2 can also regulate cancer-relevant processes like senescence (49), anoikis (50) or apoptosis (26,27,(51)(52)(53)(54)(55)(56). To our knowledge, we provide for the first time evidence that SKP2, highly expressed in pancreatic cancer (20), confers resistance towards extrinsic induction of apoptosis.…”