Down-Regulation of Osteoclast Differentiation by Daidzein via Caspase 3

Rassi, Claudia Maria; Lieberherr, Michèle; Chaumaz, Gilles; Pointillart, Alain; Cournot, Giulia

doi:10.1359/jbmr.2002.17.4.630

Cited by 88 publications

(58 citation statements)

References 74 publications

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“…Isoflavone phytoestrogens stimulate osteoblastic bone formation, inhibit osteoclastic bone resorption (52), and prevent overall bone loss in ovariectomized rats or mice (55,85). Suggested mechanisms for these effects include stimulation of proliferation of osteoblast (bone forming) cells and protection of such cells from oxidative damage, and increased apoptosis of osteoclast (bone destroying) progenitor cells (112,154,196).…”

Section: Potential Health Beneficial Effects Of Isoflavonoid Phytoestmentioning

confidence: 99%

Phytoestrogens

Dixon

2004

Annu. Rev. Plant Biol.

442

319

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▪ Abstract Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals. These compounds, termed phytoestrogens, include certain isoflavonoids, flavonoids, stilbenes, and lignans. The best-studied dietary phytoestrogens are the soy isoflavones and the flaxseed lignans. Their perceived health beneficial properties extend beyond hormone-dependent breast and prostate cancers and osteoporosis to include cognitive function, cardiovascular disease, immunity and inflammation, and reproduction and fertility. In the future, metabolic engineering of plants could generate novel and exquisitely controlled dietary sources with which to better assess the potential health beneficial effects of phytoestrogens.

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Section: Potential Health Beneficial Effects Of Isoflavonoid Phytoestmentioning

confidence: 99%

Phytoestrogens

Dixon

2004

Annu. Rev. Plant Biol.

442

319

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“…8,9) Compared with estradiol, iso‰avones have both estrogenic and anti-estrogenic eŠects. 10) Most of the estrogenic eŠects of daidzein to prompt bone formation and prevent bone resorption 11,12) have been observed in animal models and cultured cells. On the action of daidzein on bone formation, daidzein is shown to stimulate protein synthesis, alkaline phosphatase (ALP) activity and DNA content after the culture in osteoblast-like MC3T3 E1 cells for 2 days.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Effect of Daidzein on the Differentiation and Mineralization in Mouse Osteoblast-like MC3T3-E1 Cells

Chen

Xie

et al. 2006

YAKUGAKU ZASSHI

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The eŠect of daidzein, an important iso‰avone, on the diŠerentiation and mineralization in MC3T3 E1 cells, a mouse calvaria osteoblast-like cell line, was investigated. The MTT assay, the alizarin red S and von Kossa staining, the measurement of calcium (Ca) and phosphorus (P) concentrations by inductively coupled plasma-atomic emission spectrometry and the nitrophenol liberation method were used to determine the cell proliferation, mineralization and intracellular alkaline phosphatase (ALP) activity, respectively. Daidzein enhanced the cell proliferation after the culture for 2 days and the eŠect reached maximum on day 6. ALP activity and cellular Ca and P contents were increased timeand dose-dependently when the cells were treated with daidzein in the presence of disodium b-glycerophosphate and Lascorbic acid. DiŠerentiation of the cells to the mature osteoblasts was prompted under incubation in the presence of daidzein for 21 days, by the time the mineralized nodules formed. The calcium depositions of the cells by alizarin red S staining were increased signiˆcantly after the culture with daidzein as long as 28 days. It has been demonstrated that daidzein may be able to enhance the bone diŠerentiation and mineralization and prompt the bone formation in the early growing stage and the late growing stage of osteoblasts.

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“…(Arikan et al, 2011;Prentice et al, 2006;Macdonald et al, 2004;Macdonald et al, 2008;Palacios et al, 2006;Tucker et al, 1999;Lister et al, 2007;New, 2003;Trzeciakiewicz et al, 2009 Numerous studies have shown the health-promoting properties of polyphenols, providing additional mechanisms through which they promote skeletal health by reducing resorption caused by high oxidative stress (Trzeciakiewicz et al, 2009;Tucker, 2009;Hunter et al, 2008). The antioxidant properties of polyphenols have been widely studied and reported in the literature (Liu et al, 2005;Miyamoto et al,1998;Rassi et al, 2002;Viereck et al, 2002;Ward et al, 2001;. They strongly support the role of polyphenols in the delayed onset or reduction in the progression of osteoporosis.…”

Section: Introductionmentioning

confidence: 94%