Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis

Zhang, Xianwei; Qiu, Shili; Luo, Ping; Zhou, Hu; Wei, Jing; Liang, Chuizi; Tu, Jiancheng

doi:10.3233/cbm-171109

Cited by 44 publications

(43 citation statements)

References 27 publications

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“…Xie Y et al 28 found that hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer. Zhang X et al 29 showed that hsa_circ_0001649 could act as a novel prognostic biomarker and a potential therapeutic target for hepatocellular carcinoma patients. Besides, Yang F et al 30 found that circular RNA circ-LDLRAD3 could be a biomarker in diagnosis of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma

Zhu¹,

Zhang²,

Hu³

et al. 2018

Int. J. Biol. Sci.

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Chemo-resistance and lung metastasis have been the two obstacles in the osteosarcoma (OS) treatment, which is still lack of effective biomarkers for prediction, diagnosis and treatment. Circular RNA (circRNA) is a new type of endogenous noncoding RNA that could serve as ideal biomarkers in cancer because of its stable loop structure. However, little is known about the diagnostic value of circRNAs in OS as well as their associations with clinicopathologic characteristics of OS patients. In the current study, we identified a novel circRNA, hsa_circ_0081001, screened by the RNA sequencing in the three paired chemo-resistant and chemo-sensitive OS cell lines (MG63/DXR vs MG63, KHOS/DXR vs KHOS, U2OS/DXR vs U2OS), and found that hsa_circ_0081001 was significantly up-regulated in the OS cell lines, tissues and serums, associated with poor overall survival and cox multivariate analysis showed that hsa_circ_0081001 was a novel independent prognostic factor for OS patients. Then, receiver operating characteristic (ROC) curve analysis revealed that hsa_circ_0081001 could act as a biomarker for the OS diagnosis and prognosis prediction, better than alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). In addition, we preliminarily found that hsa_circ_0081001 expression level may dynamically monitor and reflect the condition changes of OS patients in a small-scale prospective clinical pretest. In conclusion, our study suggested that circulating hsa_circ_0081001 could serve as a potential biomarker and therapeutic target for OS patients.

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Section: Discussionmentioning

confidence: 99%

A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma

Zhu¹,

Zhang²,

Hu³

et al. 2018

Int. J. Biol. Sci.

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“…Further analysis suggests SHPRH-146aa protects SHPRH protein from degradation by the ubiquitin proteasome. Another recent studies indicated that circSHPRH was identified as a biomarker in hepatocellular carcinoma [104,105]. It is therefore reasonable to speculate that circSHPRH has the potential to be translated in other human cancers.…”

Section: Translation Of Circshprh In Gliomamentioning

confidence: 96%

“…It has been documented that some circRNAs exert their biological functions both through encoded peptides and by RNA-based regulatory mechanism. For example, circ-SHPRH can encode SHPRH-146aa peptide to suppress tumorigenesis in glioma [96], and it can function as miRNA sponge to inhibit HCC progression [104,105]; circZNF609 can act as miRNA sponge to promote breast cancer progression [25], and it can encode protein in Myogenesis [60]. Some circRNAs are bi-functional in human cancer, and the bi-functional ability of circRNAs remains to be explored.…”

Section: Future Perspectivementioning

confidence: 99%

Translation and functional roles of circular RNAs in human cancer

et al. 2020

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Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification and potential functions. CircRNAs play important roles in various biological functions as microRNA sponges, transcriptional regulators and combining with RNA binding proteins. Recent studies indicated that some cytoplasmic circRNAs can be effectively translated into detectable peptides, which enlightened us on the importance of circRNAs in cellular physiology function. Internal Ribosome Entry site (IRES)-and N 6-methyladenosines (m 6 A)-mediated cap-independent translation initiation have been suggested to be potential mechanism for circRNA translation. To date, several translated circRNAs have been uncovered to play pivotal roles in human cancers. In this review, we introduced the properties and functions of circRNAs, and characterized the possible mechanism of translation initiation and complexity of the translation ability of circRNAs. We summarized the emerging functions of circRNA-encoded proteins in human cancer. The works on circRNA translation will open a hidden human proteome, and enhance us to understand the importance of circRNAs in human cancer, which has been poorly explored so far.

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“…CircRNA is involved in various biological processes, including HCC cell proliferation, apoptosis and metastasis (11). For instance, overexpression of Homo sapiens circRNA_0001649 inhibits the proliferation and invasion of HCC cells (12). CircRNA circMTO1 (mitochondrial tRNA translation optimization 1) inhibits HCC progression by acting as a sponge for miRNA-9.…”

Section: Introductionmentioning

confidence: 99%

Cisplatin resistance‑associated circRNA_101237 serves as a prognostic biomarker in hepatocellular carcinoma

et al. 2020

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Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality worldwide. Despite clinical advances, the survival rate of patients with HCC remains low, as most patients are diagnosed with HCC when they are already at the advanced stage. Certain circular RNAs (circRNAs) are closely associated with the development of liver cancer. In the present study, a circRNA array was performed to screen differentially expressed circRNAs in HCC tissues. The further analysis focused on the newly identified circRNA_101237, the host gene of which, cyclin-dependent kinase 8, is located at chr13:26974589-26975761. CircRNA_101237 was determined to be upregulated in tumor tissue and serum of patients with HCC as compared with that in paracancerous tissues and the serum of healthy controls, respectively. In addition, the expression of circRNA_101237 was associated with tumor size, lymph node metastasis, distant metastasis and TNM stage. Univariate and multivariate analysis indicated that serum circRNA_101237 levels were an independent predictor of survival prognosis in patients with HCC. The overall survival of patients with high expression of circRNA_101237 was reduced compared with that of patients with low expression of circRNA_101237. Of note, cisplatin induced the expression of circRNA_101237 in HCC cells in a dose-and time-dependent manner in vitro, and the levels of circRNA_101237 in the serum of patients with cisplatin-resistant HCC and in cisplatin-resistant Huh7 cells were increased. The present study provided novel insight into the use of circRNA_101237 as a diagnostic biomarker for HCC and a potential therapeutic target.

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Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis

Abstract: Hsa_circ_0001649 could act as a novel prognostic biomarker for HCC patients. In addition, hsa_circ_ 0001649 might be a potential therapeutic target for HCC.

Cited by 44 publications

References 27 publications

A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma

A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma

Translation and functional roles of circular RNAs in human cancer

Cisplatin resistance‑associated circRNA_101237 serves as a prognostic biomarker in hepatocellular carcinoma

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