Down‐regulation of exosomal miR‐106b‐5p derived from cholesteatoma perimatrix fibroblasts promotes angiogenesis in endothelial cells by overexpression of Angiopoietin 2

Yang, Li; Liang, Jing; Hu, Juan; Ren, Xiaoyong; Sheng, Ying

doi:10.1002/cbin.11002

Cited by 17 publications

(21 citation statements)

References 32 publications

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“…Another in vitro study showed that human cholesteatoma perimatrix fibroblast-derived sEVs promote angiogenesis through downregulation of miR-106b-5p in sEVs, leading to the overexpression of Angiopoietin-2 in human umbilical vein endothelial cells (HUVECs). Furthermore, sEVs contributed to enhanced tube formation and cell migration [49]. These findings posit sEVs as important factors in the pathogenesis and progression of OME and chronic otitis media with cholesteatoma.…”

Section: Sevs and Airway Epitheliummentioning

confidence: 72%

The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases

et al. 2021

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Extracellular vesicles (EVs) are produced and released by all cells and are present in all body fluids. They exist in a variety of sizes, however, small extracellular vesicles (sEVs), the EV subset with a size range from 30 to 150 nm, are of current interest. By transporting a complex cargo that includes genetic material, proteins, lipids, and signaling molecules, sEVs can alter the state of recipient cells. The role of sEVs in mediating inflammatory processes and responses of the immune system is well-documented, and adds another layer of complexity to our understanding of frequent diseases, including chronic rhinosinusitis (CRS), asthma, chronic obstructive pulmonary disease (COPD), and upper airway infections. In these diseases, two aspects of sEV biology are of particular interest: (1) sEVs might be involved in the etiopathogenesis of inflammatory airway diseases, and might emerge as attractive therapeutic targets, and (2) sEVs might be of diagnostic or prognostic relevance. The purpose of this review is to outline the biological functions of sEVs and their capacity to both augment and attenuate inflammation and immune response in the context of pathogen invasion, CRS, asthma, and COPD.

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Section: Sevs and Airway Epitheliummentioning

confidence: 72%

The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases

et al. 2021

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“…miR-106b-5p targets cTSA to suppress the invasion and metastasis of colorectal cancer (31), but miR-106b-5p promotes stem cell-like properties of hepatocellular carcinoma cells through targeting PTEN via a PI3K/Akt signaling pathway (32). Li et al (20) demonstrated that miR-106b-5p binds the 3'-UTR of Angpt2 to induce migration and tube formation of HUVEcs, and hcPFs-exosome transport to endothelial cells expressing relatively low amounts of miR-106b-5p, promoting angiogenesis through upregulation of Angpt2 (20). miR-106b-5p is pivotal in regulating cell proliferation and migration.…”

Section: Discussionmentioning

confidence: 99%

“…Li et al (20) demonstrated that miR-106b-5p binds to the 3'-UTR of Angiopoietin 2 (Angpt2) to induce migration and tube formation of HUVEcs, and human cholesteatoma perimatrix fibroblasts (hCPFs)-exosomes transports miR-106b-5p to endothelial cells and promotes angiogenesis by upregulating expression of Angpt2 (20). miR-106b-5p is pivotal in regulating cell proliferation and migration.…”

Section: Introductionmentioning

confidence: 99%

miR‑106b‑5p modulates acute pulmonary embolism via NOR1 in pulmonary artery smooth muscle cells

Chen

Zhang

et al. 2020

Int J Mol Med

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Acute pulmonary embolism (APE) is a common cause of acute cardiovascular failure and has a high morbidity and mortality rate. Inhibiting the excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMcs) is a potential treatment strategy following an APE. Various microRNAs (miRNAs/miRs) have been shown to regulate cell proliferation, apoptosis and other physiological processes. However, the specific mechanisms underlying the action of multiple miRNAs are still not understood in APE. In the present study, the role of miR-106b-5p on APE was demonstrated in platelet-derived growth factor (PdGF)-induced PASMcs in vitro and in an APE-mouse model in vivo. The results showed that miR-106b-5p expression was downregulated in PdGF-induced PASMcs and APE mice, and NOR1 levels were upregulated. Proliferating cell nuclear antigen (PcNA) expression levels in cells and proliferation of PASMcs proliferation and migration were reduced following treatment with miR-106b-5p agomiR, and increased following treatment with miR-106b-5p antagomiR. miR-106b-5p targeted the 3' untranslated region of NOR-1 mRNA and reduced NOR1 expression. NOR1 overexpression reversed the effects of miR-106-5p on PdGF-induced PASMcs. The functional roles of miR-106b-5p in PdGF-induced PASMcs and an APE mouse-model, and the underlying molecular mechanisms were evaluated. AgomiR-106b-5p improved APE-induced mortality and pulmonary vascular proliferation in mice. These data suggest that miR-106-5p is a novel regulator of proliferation of PASMcs and of pulmonary vascular remodeling through PdGF-induced PASMcs in an APE mouse model via targeting NOR1. These results expand the understanding of the pathogenesis underlying APE and highlight potential novel therapeutic targets.

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“…Yang et al showed that exosomes could promote the ECs angiogenesis induced by oxygen-glucose deprivation via miR-181b-5p/TRPM7 axis [37]. On the contrary, it had been proven that up-regulation of exosomal miR-106b-5p suppressed angiogenesis in ECs by overexpression of angiopoietin 2 [38]. Besides, it had been indicated that exosomes exerted an anti-angiogenic function through transfer of miR-320 into ECs [39].…”

Section: Exosomal Mirnas and Ecs Functionsmentioning

confidence: 99%

Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Ni¹,

Lin²,

Zhan³

et al. 2020

Aging and disease

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Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vascular aging, which could influence the threshold, process, and severity of vascular related diseases. Accumulating evidences demonstrate that exosomes serve as novel intercellular information communicator between cell to cell by delivering variety biologically active cargos, especially exosomal non-coding RNAs (ncRNAs), which are associated with most of aging-related biological and functional disorders. In this review, we will summerize the emerging roles and mechanisms of exosomal ncRNAs in vascular aging and vascular aging related diseases, focusing on the role of exosomal miRNAs and lncRNAs in regulating the functions of ECs and VSMCs. Moreover, the relationship between the ECs and VSMCs linked by exosomes, the potential diagnostic and therapeutic application of exosomes in vascular aging and the clinical evaluation and treatment of vascular aging and vascular aging related diseases will also be discussed.

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Down‐regulation of exosomal miR‐106b‐5p derived from cholesteatoma perimatrix fibroblasts promotes angiogenesis in endothelial cells by overexpression of Angiopoietin 2

Cited by 17 publications

References 32 publications

The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases

The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases

miR‑106b‑5p modulates acute pulmonary embolism via NOR1 in pulmonary artery smooth muscle cells

Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

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