The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases

Piszczatowska, Katarzyna; Czerwaty, Katarzyna; Cyran, Anna M.; Fiedler, Mathias; Ludwig, Nils; Brzost, Jacek; Szczepański, Mirosław J.

doi:10.3390/diagnostics11020222

Cited by 7 publications

(4 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ApoVs are mostly composed of protein, nucleotides, lipids, and metabolites [41,42]. They are thought to be an evolutionarily conserved method of intercellular communication, sending signals from parent cells to the extracellular environment to control the activity of recipient cells [42].…”

Section: Discussionmentioning

confidence: 99%

Apoptotic Vesicles Derived from Dental Pulp Stem Cells Promote Bone Formation through the ERK1/2 Signaling Pathway

Yang,

Zhu,

Shao

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Osteoporosis is a common degenerative bone disease. The treatment of osteoporosis remains a clinical challenge in light of the increasing aging population. Human dental pulp stem cells (DPSCs), a type of mesenchymal stem cells (MSCs), are easy to obtain and have a high proliferation ability, playing an important role in the treatment of osteoporosis. However, MSCs undergo apoptosis within a short time when used in vivo; therefore, apoptotic vesicles (apoVs) have attracted increasing attention. Currently, the osteogenic effect of DPSC-derived apoVs is unknown; therefore, this study aimed to determine the role of DPSC-derived apoVs and their potential mechanisms in bone regeneration. We found that MSCs could take up DPSC-derived apoVs, which then promoted MSC osteogenesis in vitro. Moreover, apoVs could increase the trabecular bone count and bone mineral density in the mouse osteoporosis model and could promote bone formation in rat cranial defects in vivo. Mechanistically, apoVs promoted MSC osteogenesis by activating the extracellular regulated kinase (ERK)1/2 signaling pathway. Consequently, we propose a novel therapy comprising DPSC-derived apoVs, representing a promising approach to treat bone loss and bone defects.

show abstract

Section: Discussionmentioning

confidence: 99%

Apoptotic Vesicles Derived from Dental Pulp Stem Cells Promote Bone Formation through the ERK1/2 Signaling Pathway

Yang,

Zhu,

Shao

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…Chronic rhinosinusitis (CRS) is a persistent inflammatory disease of the paranasal sinus mucosa with multifactorial etiology, including genetic, environmental, bacterial, and immunological contributions [ 88 ]. Traditionally, CRS was classified phenotypically as occurring with (CRSwNP) or without nasal polyps, which failed to account for the range of mechanisms which can cause the disease [ 89 ]. The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 advises against phenotypic classification and instead focuses on the pathophysiology of CRS to classify [ 90 ].…”

Section: Role Of Evs In Diseases Of the Ear Nose And Throatmentioning

confidence: 99%

The Role of Extracellular Vesicles in Diseases of the Ear, Nose, and Throat

2022

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are membranous nanoparticles produced by most cell types into the extracellular space and play an important role in cell-to-cell communication. Historically, EVs were categorized based on their methods of biogenesis and size into three groups: exosomes, microvesicles, and apoptotic bodies. Most recently, EV nomenclature has evolved to categorize these nanoparticles based on their size, surface markers, and/or the cell type which secreted them. Many techniques have been adopted in recent years which leverage these characteristics to isolate them from cell culture media and biological fluids. EVs carry various “cargo”, including DNA, RNA, proteins, and small signaling molecules. After isolation, EVs can be characterized by various methods to analyze their unique cargo profiles which define their role in cell-to-cell communication, normal physiology, and disease progression. The study of EV cargo has become more common recently as we continue to delineate their role in various human diseases. Further understanding these mechanisms may allow for the future use of EVs as novel biomarkers and therapeutic targets in diseases. Furthermore, their unique cargo delivery mechanisms may one day be exploited to selectively deliver therapeutic agents and drugs. Despite the growing research interest in EVs, limited studies have focused on the role of EVs in the diseases of the ear, nose, and throat. In this review, we will introduce EVs and their cargo, discuss methods of isolation and characterization, and summarize the most up-to-date literature thus far into the role of EVs in diseases of the ear, nose, and throat.

show abstract

“…EVs are secreted by the lining of the respiratory tract similar to any other cell in the body and their role in the pathogenesis of lung diseases has been established in previous studies. 133 , 134 Recent studies show that EVs and viruses are interdependent on each other for cellular entry and exit owing to their similar physicochemical properties, for example, size and heterogeneous size distribution. 134 Therefore, trials using EVs loaded with antiviral medications to block viral intracellular entry can be explored.…”

Section: Evs In the Treatment Of Lung Diseases Including Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-cov-2) Infectionmentioning

confidence: 99%

“… 133 , 134 Recent studies show that EVs and viruses are interdependent on each other for cellular entry and exit owing to their similar physicochemical properties, for example, size and heterogeneous size distribution. 134 Therefore, trials using EVs loaded with antiviral medications to block viral intracellular entry can be explored.…”

Section: Evs In the Treatment Of Lung Diseases Including Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-cov-2) Infectionmentioning

confidence: 99%

Diagnostic and Therapeutic Potential of Extracellular Vesicles

Kodam

Ullah

2021

Technol Cancer Res Treat

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. They interact with target organs and bind to the receptors. Their target specificity is important to use EVs as noninvasive diagnostic and prognostic tools. EVs play a vital role in normal physiology and cellular communication. They are known to protect their cargo from degradation, which makes them important drug carriers for targeted drug delivery. Using EVs with markers and tracking their path in systemic circulation can be revolutionary in using them as diagnostic tools. We will discuss the scope of this in this paper. Although there are limitations in EVs isolation and storage, their high biocompatibility will fuel more innovations to overcome these challenges.

show abstract

The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases

Cited by 7 publications

References 108 publications

Apoptotic Vesicles Derived from Dental Pulp Stem Cells Promote Bone Formation through the ERK1/2 Signaling Pathway

Apoptotic Vesicles Derived from Dental Pulp Stem Cells Promote Bone Formation through the ERK1/2 Signaling Pathway

The Role of Extracellular Vesicles in Diseases of the Ear, Nose, and Throat

Diagnostic and Therapeutic Potential of Extracellular Vesicles

Contact Info

Product

Resources

About