Down-Regulation of CXCL12 by DNA Hypermethylation and Its Involvement in Gastric Cancer Metastatic Progression

Yu, Zhi; Chen, Jing; Zhang, Shuanglong; Chang, Xiaojing; Ma, Jing-Guo; Dai, Dong‐Qiu

doi:10.1007/s10620-011-1922-5

Cited by 38 publications

(30 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In breast cancer [29] and gastric cancer [30] patients, a low expression of CXCL12 but not of CXCR4 was related to a decrease in the regional extension of the disease.…”

Section: Discussionmentioning

confidence: 91%

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

León

Diez

García

et al. 2016

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Expression of the CXCL12/CXCR4 chemokine axis has been related with the appearance of metastatic recurrence survival, including regional and distant recurrence, in patients with head and neck squamous cell carcinoma (HNSCC). RT-PCR was used to determine mRNA expression levels of CXCL12 and CXCR4 in biopsy tumor samples in 111 patients with HNSCC. Five-year regional recurrence-free survival for patients with low CXCR4 expression (n = 39, 31.5 %) was 97.4 %, for patients with high CXCR4/high CXCL12 expression (n = 22, 19.8 %) it was 94.7 %, and for patients with high CXCR4/low CXCL12 expression (n = 50, 45.0 %) it was 63.3 %. We found significant differences in the regional recurrence-free survival according to CXCR4/CXCL12 expression values (P = 0.001). HNSCC patients with high CXCR4 and low CXCL12 expression values had a significantly higher risk of regional recurrence and could benefit from a more intense treatment of lymph node areas in the neck.

show abstract

“…In breast cancer [29] and gastric cancer [30] patients, a low expression of CXCL12 but not of CXCR4 was related to a decrease in the regional extension of the disease.…”

Section: Discussionmentioning

confidence: 91%

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

León

Diez

García

et al. 2016

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…The role of CXCR7 in gastric and small bowel cancer is poorly understood. CXCR7 transcripts have been detected in gastric cancer cells, including MGC-803, SGC-7901 and BGC-823 cells (37). In a previous study, Lee et al (2) reported that CXCR7 was differentially expressed in gastric adenocarcinoma tissues.…”

Section: Cxcr7 In Cancer Of the Gastrointestinal Systemmentioning

confidence: 97%

C-X-C motif receptor 7 in gastrointestinal cancer

et al. 2015

View full text Add to dashboard Cite

Abstract. Chemokine receptors are key mediators of normal physiology and numerous pathological conditions, including inflammation and cancer. This receptor family is an emerging target for anticancer drug development. C-X-C motif receptor 7 (CXCR7) is an atypical chemokine receptor that was first cloned from a canine cDNA library as an orphan receptor and was initially named receptor dog cDNA 1 (RDC1). Shortly after demonstrating that RDC1 binds with its ligand, stromal cell-derived factor-1α and interferon-inducible T-cell α chemoattractant, RDC1 was officially deorphanized and renamed CXCR7, as the seventh receptor in the CXC class of the chemokine receptor family. Recent accumulating evidence has demonstrated that CXCR7 expression is augmented in the majority of tumor cells compared with their normal counterparts and is involved in cell proliferation, survival, migration, invasion and angiogenesis during the initiation and progression of breast, lung and prostate cancer. In the present review, the expression and role of CXCR7, as well as its clinical relevance in cancer of the gastrointestinal system, were investigated. In addition, the potential of this chemokine receptor as a therapeutic target in the treatment of gastrointestinal cancer was discussed.

show abstract

“…Interestingly, p38 MAPK inhibitors induced significant downregulation of multidrug resistance-1 gene expression, a well- Chemokine defined marker of resistance to chemotherapy, which possibly induced susceptibility to the cisplatin treatment in this model [119] . In a separate study, Zhi et al [120] examined the expression of CXCL12 in normal gastric tissue, gastric cancer cell lines, 35 primary gastric carcinomas and corresponding normal gastric tissues. They found that CXCL12 was downregulated in gastric cancer cell lines and patient samples of primary gastric carcinomas compared to normal samples.…”

Section: Stomachmentioning

confidence: 99%

“…They provided evidence to show that CXCL12 expression was inversely associated with lymph node metastasis and histological grade. They concluded the possible cause of this downregulation of CXCL12 expression to be hypermethylation of the CXCL12 promoter, as treatment of highly metastatic cancer cell lines with a demethylating agent impaired its invasive phenotype [120] . One possible explanation for this reduction in CXCL12 might be to permit CXCR4-expressing gastric cancer cells to sense a CXCL12 gradient from target lymph nodes or other organs, which would otherwise be masked by CXCL12 expressed by the cancer cells.…”

Section: Stomachmentioning

confidence: 99%

See 1 more Smart Citation

Chemokines, chemokine receptors and the gastrointestinal system

Miyazaki¹,

Takabe²,

Yeudall³

2013

WJG

View full text Add to dashboard Cite

Core tip: The chemokine network makes an attractive target for therapeutic intervention in many tumor types, including those of the gastrointestinal tract. However, we need to define more selective and specific targets, to minimize systemic side effects during treatment. INTRODUCTION Cancer development and progression in the gastrointestinal tractCancer is a disease in which normal cells acquire genetic and epigenetic abnormalities [1,2] , leading to disorientation of conventional processes for the maintenance of normal cell physiology. These aberrant genetic and epigenetic modifications to the normal cell induce abnormal cell motility, proliferation, and survival, eventually enabling these cells to invade into adjacent tissues and even to migrate to regional or distant organs where they may grow continuously as metastatic lesions [3] . For many cancer patients, metastasis is generally the major cause of disease-related death [4,5] . Therefore, it is indispensable to elucidate the basic molecular mechanisms of tumor development to identify effective therapeutic targets, which can possibly reduce the side-effects of treatment, and define useful molecular markers for early detection and prediction of disease course. Especially, the newly emerged concept of personalized medicine may require in-depth assessment of potential therapeutic molecular target(s) in each individual case through analysis of sig- REVIEW Chemokines, chemokine receptors and the gastrointestinal system AbstractThe biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

show abstract

Down-Regulation of CXCL12 by DNA Hypermethylation and Its Involvement in Gastric Cancer Metastatic Progression

Abstract: Collectively, our results suggest that the aberrant methylation of CXCL12 frequently occurs in the down-regulation of CXCL12 in gastric cancers and that it may play a role in the metastasis of gastric cancer.

Cited by 38 publications

References 40 publications

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma

C-X-C motif receptor 7 in gastrointestinal cancer

Chemokines, chemokine receptors and the gastrointestinal system

Contact Info

Product

Resources

About