Chemokines, chemokine receptors and the gastrointestinal system

Miyazaki, Hiroshi; Takabe, Kazuaki; Yeudall, W. Andrew

doi:10.3748/wjg.v19.i19.2847

Cited by 18 publications

(11 citation statements)

References 178 publications

(224 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, lncRNAs may be the local regulators of these coding genes that participate in these activities, and lncRNAs may indirectly promote cancer. Additionally, we detect fibroblast growth factor binding (GO:0017134) and C-X3-C chemokine binding (GO:0019960) molecular functions which are important for both stomach adenocarcinoma and esophageal carcinoma [34,35].…”

Section: Lncrna Based Functional Similarity Of Cancersmentioning

confidence: 99%

Functional Enrichment Analysis of Deregulated Long Non-Coding RNAs in Cancer Based on their Genomic Neighbors

Olgun

Taştan

2020

Preprint

View full text Add to dashboard Cite

The dysregulation of long non-coding RNAs' (lncRNAs) expressions has been implicated in cancer. Since most of the lncRNAs' are not functionally characterized well, investigating the set of perturbed lncRNAs are is challenging. Existing methods that inspect lncRNAs functionally rely on the co-expressed coding genes, which are far better characterized functionally. LncRNAs can be known to act as transcriptional regulators; they may activate or repress the neighborhood's coding genes on the genome. Based on this, in this work, we aim to analyze the deregulated lncRNAs in cancer by taking into account their ability to regulate nearby loci on the genome. We perform functional analysis on differentially expressed lncRNAs for 28 different cancers considering their adjacent coding genes. We identify that some deregulated lncRNAs are cancer-specific, but a substantial number of lncRNAs are shared across cancers. Next, we assess the similarities of the cancer types based on the functional enrichment of the deregulated lncRNA sets. We find some cancers are very similar in the functions and biological processes related to the deregulated lncRNAs. We observe that some of the cancers for which we find similarity can be linked through primary, metastatic site relations. We investigate the similarity of enriched functional terms for the deregulated lncRNAs and the mRNAs. We further assess the enriched functions' similarity to the functions and processes that the known cancer driver genes take place. We believe that our methodology help to understand the impact of the lncRNAs in cancer functionally.

show abstract

Section: Lncrna Based Functional Similarity Of Cancersmentioning

confidence: 99%

Functional Enrichment Analysis of Deregulated Long Non-Coding RNAs in Cancer Based on their Genomic Neighbors

Olgun

Taştan

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In vivo the anti-inflammatory effects were shown by inhibition of transcriptions factors like nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells (NF-κB) and by suppression of cyclooxygenase 2 (COX-2) enzymes[ 12 ]. In patients with IBD chemokines and chemokine receptors are increased[ 13 ]. Phytochemicals have been shown to suppress inflammatory signal transduction systems leading to autophagy and apoptosis[ 14 ].…”

Section: Anti-inflammatory Effects Of Flavonoidsmentioning

confidence: 99%

Regulation of the intestinal immune system by flavonoids and its utility in chronic inflammatory bowel disease

Hoensch

Weigmann²

2018

WJG

View full text Add to dashboard Cite

Flavonoids are phytochemicals which can regulate the activity of the intestinal immune system. In patients with chronic inflammatory bowel disease (IBD) there is an overexpression and imbalance of the components of the inflammatory immune reactions which are chronically activated. Suppression of inflammation can be achieved by anti-inflammatory drugs which are used in clinical medicine but these can cause serious side effects. Flavonoids can have natural immunosuppressive properties and inhibit the activation of immune cells and its effectors (chemokines, TNF-, cytokines). Phytochemicals such as flavonoids bind to the nuclear Ah (aryl hydrocarbon) -receptor thereby stimulating protective enzyme activities. As shown by clinical evidence in patients and by experimental work some flavonoids (apigenin, epigallocatechin gallate) were effective in the inhibition of inflammation. Instead of or additionally to anti-inflammatory drugs flavonoids can be used in IBD patients to treat the over-reactive immunologic system. This is accomplished by upregulation of the Ah-receptor. Flavonoids interact with toll-like receptors expressing on the surface of immune cells, then they were internalized to the cytosol and transferred into the nucleus, where they were attached to the Ah-receptor. The Ah-receptor binds to the Ah-R nuclear translocator and via Ah response element beneficial protective enzymes and cytokines are induced, leading to upregulation of the anti-inflammatory system.

show abstract

“…Squamous cell carcinomas of the head and neck are a heterogeneous group of malignancies involving the oral cavity, oropharynx, larynx and hypopharynx, and account for >90% of malignant tumors in the oral cavity (29,30). The biological properties of squamous cell carcinoma are intimately regulated by various cytokines and growth factors.…”

Section: Cxcr7 In Cancer Of the Gastrointestinal Systemmentioning

confidence: 99%

C-X-C motif receptor 7 in gastrointestinal cancer

et al. 2015

View full text Add to dashboard Cite

Abstract. Chemokine receptors are key mediators of normal physiology and numerous pathological conditions, including inflammation and cancer. This receptor family is an emerging target for anticancer drug development. C-X-C motif receptor 7 (CXCR7) is an atypical chemokine receptor that was first cloned from a canine cDNA library as an orphan receptor and was initially named receptor dog cDNA 1 (RDC1). Shortly after demonstrating that RDC1 binds with its ligand, stromal cell-derived factor-1α and interferon-inducible T-cell α chemoattractant, RDC1 was officially deorphanized and renamed CXCR7, as the seventh receptor in the CXC class of the chemokine receptor family. Recent accumulating evidence has demonstrated that CXCR7 expression is augmented in the majority of tumor cells compared with their normal counterparts and is involved in cell proliferation, survival, migration, invasion and angiogenesis during the initiation and progression of breast, lung and prostate cancer. In the present review, the expression and role of CXCR7, as well as its clinical relevance in cancer of the gastrointestinal system, were investigated. In addition, the potential of this chemokine receptor as a therapeutic target in the treatment of gastrointestinal cancer was discussed.

show abstract

Chemokines, chemokine receptors and the gastrointestinal system

Cited by 18 publications

References 178 publications

Functional Enrichment Analysis of Deregulated Long Non-Coding RNAs in Cancer Based on their Genomic Neighbors

Functional Enrichment Analysis of Deregulated Long Non-Coding RNAs in Cancer Based on their Genomic Neighbors

Regulation of the intestinal immune system by flavonoids and its utility in chronic inflammatory bowel disease

C-X-C motif receptor 7 in gastrointestinal cancer

Contact Info

Product

Resources

About