Doubling immunochemistry laboratory testing efficiency with the cobas e 801 module while maintaining consistency in analytical performance

Findeisen, Peter; Zahn, Ingrid; Fiedler, Georg Martin; Leichtle, Alexander Benedikt; Wang, S.; Soria, G.; Johnson, PhilipL .; Henzell, J.; Hegel, Johannes Kolja; Bendavid, Claude; Collet, Nicolas; McGovern, Margaret M.; Klopprogge, K.

doi:10.1016/j.clinbiochem.2018.05.019

Cited by 5 publications

(2 citation statements)

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“…Serum vitamin B12 level was measured using the electrochemiluminescence immunoassay method using a Roche Cobas e-801 device. 10 Serum bilirubin levels were measured using the colorimetric diazo method using a Roche Cobas c501 device. 11 Prolonged jaundice diagnosis was determined by identifying serum total bilirubin levels above 5 mg/dL on the 14th day or later in term infants and the 21st day or later in preterm infants.…”

Section: Methodsmentioning

confidence: 99%

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

Aygün

Sayman

Ertürk

et al. 2023

Journal of Child Science

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Objective Prolonged jaundice is defined as a serum bilirubin level of more than 5 mg/dL, which persists at postnatal 14 days in term infants and 21 days following birth in preterm infants. Although the underlying causes cannot be found in the majority of prolonged jaundice cases, this may be the first sign of a serious issue. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice in newborns. Material and Methods This descriptive cross-sectional study was performed in a university hospital between January 1, 2015 and October 1, 2020. All participants consisted of infants who were admitted to the pediatric outpatient clinics. Infants > 35 weeks of gestation and with prolonged jaundice of unknown etiology were included in the study group. The control group consisted of infants > 35 weeks of gestation without prolonged jaundice. Demographic and clinical characteristics and serum vitamin B12 levels were evaluated comparatively. Results A total of 126 infants, 66 of whom had prolonged jaundice, were included. The mean gestational week of the study group was 38.4 ± 1.8, and the control group was 38.6 ± 1.9 weeks. There was no difference between the groups in terms of demographics and laboratory data. The vitamin B12 level of the study group was significantly lower (median = 170 pg/mL) than the control (median = 268 pg/mL). Conclusion Based on the findings of this study, vitamin B12 deficiency was thought to be an important cause of prolonged jaundice, and further studies are needed to explain the role of vitamin B12 deficiency in the etiology of prolonged jaundice.

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Section: Methodsmentioning

confidence: 99%

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

Aygün

Sayman

Ertürk

et al. 2023

Journal of Child Science

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Untitled

2023

Journal of Child Science

View full text Add to dashboard Cite

Objective Prolonged jaundice is defined as a serum bilirubin level of more than 5 mg/dL, which persists at postnatal 14 days in term infants and 21 days following birth in preterm infants. Although the underlying causes cannot be found in the majority of prolonged jaundice cases, this may be the first sign of a serious issue. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice in newborns. Material and MethodsThis descriptive cross-sectional study was performed in a university hospital between January 1, 2015 and October 1, 2020. All participants consisted of infants who were admitted to the pediatric outpatient clinics. Infants > 35 weeks of gestation and with prolonged jaundice of unknown etiology were included in the study group. The control group consisted of infants > 35 weeks of gestation without prolonged jaundice. Demographic and clinical characteristics and serum vitamin B12 levels were evaluated comparatively. Results A total of 126 infants, 66 of whom had prolonged jaundice, were included. The mean gestational week of the study group was 38.4 AE 1.8, and the control group was 38.6 AE 1.9 weeks. There was no difference between the groups in terms of demographics and laboratory data. The vitamin B12 level of the study group was significantly lower (median ¼ 170 pg/mL) than the control (median ¼ 268 pg/mL). Conclusion Based on the findings of this study, vitamin B12 deficiency was thought to be an important cause of prolonged jaundice, and further studies are needed to explain the role of vitamin B12 deficiency in the etiology of prolonged jaundice.

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Evaluation of a Compact, Portable Centrifuge for Separating Microvolume Blood Samples at the Point of Collection

Iacovetti,

Collier,

Setzer

et al. 2023

The Journal of Applied Laboratory Medicine

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Background The increased demand for decentralized blood sample collection presents numerous operational challenges for diagnostics providers. Sample degradation including sample hemolysis due to time, temperature, and handling between collection and laboratory analysis leads to limited test menus and unreliable results. Here we introduce the lightweight, portable Labcorp TrueSpin™ for rapid point-of-care blood separation using commercially available microvolume blood collection tubes. The TrueSpin is a class I FDA-registered device designed for untrained users. The centrifuge runs on AA batteries and separates a blood sample in 5 minutes. Methods Here we describe a series of studies evaluating sample quality and analyte stability in serum samples collected into gel microtubes and processed using the TrueSpin. Hemolysis, residual red blood cell concentration, sample volume, and serum-based chemistry analyte stability were evaluated. Results No significant difference was seen in hemolysis or residual red blood cell concentration in serum samples prepared by TrueSpin compared to the reference method. Additionally, capillary and venous blood samples separated using the TrueSpin and exposed to International Safe Transit Association 3A-simulated shipping conditions were shown to yield acceptable sample volume and quality for laboratory analysis. Finally, we show that many common serum-based chemistry analytes have limited (< 1 day) stability if uncentrifuged but improve to ≥ 3-day stability following TrueSpin separation and refrigerated or room temperature storage. Conclusions These findings suggest that the TrueSpin is a simple and effective solution for remote sample separation and may enable broader test menus and increased test result reliability for decentralized sample collection pursuits.

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Doubling immunochemistry laboratory testing efficiency with the cobas e 801 module while maintaining consistency in analytical performance

Cited by 5 publications

References 9 publications

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

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Evaluation of a Compact, Portable Centrifuge for Separating Microvolume Blood Samples at the Point of Collection

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