Double stranded aptamer-anchored reduced graphene oxide as target-specific nano detector

Kim, Mi‐Gyeong; Shon, Yuna; Lee, Jaiwoo; Byun, Youngro; Choi, Byeong‐Sun; Kim, Young Bong; Oh, Yu‐Kyoung

doi:10.1016/j.biomaterials.2013.12.058

Cited by 37 publications

(23 citation statements)

References 27 publications

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“…As shown recently, both GO and rGO can quench the fluorescence of emitters placed in their vicinity with the resonance energy transfer being considered as the most probable source for this effect [4][5][6][7]11,[17][18][19][20][21]. Indeed, both GO and rGO materials can quench fluorescence of dyes or biomolecules [4][5][6]17,18,22,23], quantum dots [7,11] and conjugated polymers [19][20][21].…”

Section: Introductionmentioning

confidence: 92%

“…Indeed, both GO and rGO materials can quench fluorescence of dyes or biomolecules [4][5][6]17,18,22,23], quantum dots [7,11] and conjugated polymers [19][20][21]. This property renders such hybrid materials as promising structures for biosensing or imaging [4,6,17].…”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, in the case of non-emitting acceptors, the energy is dissipated non-radiatively, predominantly as heat. Such a scenario appears in hybrid nanostructures that involve metallic nanoparticles [3] or carbon-based materials [4][5][6][7]. Following the first reports on obtaining graphene [8,9], a two-dimensional honeycomb carbon lattice known for its unique optoelectronic, thermal, and mechanical properties, several groups have applied this material as an acceptor in studying fluorescence of emitters placed in its vicinity [10][11][12][13].…”

mentioning

confidence: 99%

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Fluorescence imaging of hybrid nanostructures composed of natural photosynthetic complexes and reduced graphene oxide

Twardowska¹,

Chomicki²,

Kamińska³

et al. 2015

Nanospectroscopy

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rates, this technique in its many facets provides insight into various processes such as energy transfer, electron transfer, excited state reactions, molecular rearrangements, plasmonic interactions, and complex formation [1]. These are undoubtedly the key effects determining the properties of materials at the nanoscale, which can lead to changes in fluorescence intensity. While enhancement of fluorescence intensity can be most frequently induced by coupling fluorophores with metallic nanoparticles [2], either through absorption or fluorescence rate increase, fluorescence quenching is often the result of energy transfer to neighbouring acceptors. If these acceptors can emit fluorescence, the energy transfer leads to an increase of acceptor fluorescence intensity [1]; its fluorescence dynamics can also be affected. Alternatively, in the case of non-emitting acceptors, the energy is dissipated non-radiatively, predominantly as heat. Such a scenario appears in hybrid nanostructures that involve metallic nanoparticles [3] or carbon-based materials [4][5][6][7]. Following the first reports on obtaining graphene [8,9], a two-dimensional honeycomb carbon lattice known for its unique optoelectronic, thermal, and mechanical properties, several groups have applied this material as an acceptor in studying fluorescence of emitters placed in its vicinity [10][11][12][13]. The results indicate that incorporating graphene in such structures provides unexplored opportunities in devising novel architectures possibly applicable in photonics, optoelectronics, and biosensing [12][13][14][15].In addition to graphene, other carbon-based compounds, namely graphene oxide (GO) and reduced graphene oxide (rGO), have been suggested as components of functional hybrid nanostructures. At first, they were considered disadvantageous, described often as distorted forms of highly crystalline graphene. Nevertheless, easy processing, solubility in various solvents, e.g. water, and the presence of oxygen containing functional groups [16], mean both GO and rGO are attractive materials for coupling them with other nanostructures. Particularly Abstract: Herein, we describe the results of fluorescence microscopy imaging of peridinin-chlorophyll-protein (PCP) photosynthetic complex mixed with reduced graphene oxide (rGO). Upon incorporation of rGO the fluorescence image of PCP changes substantially from one characterized by uniform intensity towards a more complex pattern. The isolated bright spots feature up to ten times higher emission intensity compared to the fluorescence of PCP in the reference sample, where no rGO was added. The number of the bright spots increases with increasing rGO concentration. At the same time the fluorescence intensity away from the bright spots in the PCP/rGO hybrid system is quenched in comparison to the PCP -only reference.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Fluorescence imaging of hybrid nanostructures composed of natural photosynthetic complexes and reduced graphene oxide

Twardowska¹,

Chomicki²,

Kamińska³

et al. 2015

Nanospectroscopy

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“…181 Kim et al 182 developed a double-stranded and dualanchored aptamer on reduced GO nanosheets for speedy and specif ic detection of the target protein in biological and clinical patient samples. As a model target protein, interferon-gamma was used.…”

Section: Optical Fluorescencementioning

confidence: 99%

“…This approach allowed a rapid quantification of the target protein in HIV-positive serum samples. 182 Another option for virus identification by optical fluorescence detection is the application of the retroviruses tagged with a genetically encoded pH-sensor and a fluorescent content marker enabled simultaneous measurements of the pH drop within virus-carrying vesicles and the resulting virus-endosome fusion. 183 Label-free chemiresistive sensors based on a polypyrrole nanoribbon were batch-fabricated by a lithographically patterned nanowire electrodeposition technique.…”

Section: Optical Fluorescencementioning

confidence: 99%

Nanoscale virus biosensors: state of the art

Krejčová¹,

Michálek²,

Rodrigo³

et al. 2015

NDD

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Abstract:Since the beginning of the new millennium, viruses have shown huge epidemiological and pandemic potential: severe acute respiratory syndrome (SARS) in 2002, pandemic swine flu in 2009, and last but not least the West African Ebola outbreak in 2014. The occurrence and spread of the new virus in pandemic dimension poses a threat to the health and lives of 7 billion people worldwide. There is a growing urgency for highly sensitive and selective detection techniques, usable for a wide number of applications, including disease diagnosis, pharmaceutical research, agriculture, as well as preventive measures. Nanobiosensors represent a new promising tool for virus detection. This review gives a brief survey of the issue of viral detection, comprising diagnostics of target structure of viruses such as nucleic acids or proteins. This review covers different detection principles, methods of fabrication, and applications of virus biosensors.

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Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

et al. 2019

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River Scholar of China and the Foreign Academicians of the Russian Academy of Engineering and Russian Academy of Science. Her research interests mainly focus on bioeffects and safety evaluation of nanomaterials and environmental pollution analysis and control. Rui L. Reis obtained his Ph.D. and D.Sc. in polymer engineering-biomaterials & tissue engineering from the University of Minho, Portugal. He is vice president for Research and Innovation of UMinho and the director of the 3B's Research Group and ICVS/3B's Associate Laboratory. He is a full professor of Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho and honorary professor in four different Asian Universities. His main area of research is the development of biomaterials from natural origin polymers, and using those in combination with different stem cells for several strategies for tissue engineering and regenerative medicine, applied to distinct human tissues.

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Double stranded aptamer-anchored reduced graphene oxide as target-specific nano detector

Cited by 37 publications

References 27 publications

Fluorescence imaging of hybrid nanostructures composed of natural photosynthetic complexes and reduced graphene oxide

Fluorescence imaging of hybrid nanostructures composed of natural photosynthetic complexes and reduced graphene oxide

Nanoscale virus biosensors: state of the art

Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

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