2019
DOI: 10.1002/adma.201902409
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Tumor Targeting Strategies of Smart Fluorescent Nanoparticles and Their Applications in Cancer Diagnosis and Treatment

Abstract: River Scholar of China and the Foreign Academicians of the Russian Academy of Engineering and Russian Academy of Science. Her research interests mainly focus on bioeffects and safety evaluation of nanomaterials and environmental pollution analysis and control. Rui L. Reis obtained his Ph.D. and D.Sc. in polymer engineering-biomaterials & tissue engineering from the University of Minho, Portugal. He is vice president for Research and Innovation of UMinho and the director of the 3B's Research Group and ICVS/3B's… Show more

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Cited by 191 publications
(126 citation statements)
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References 438 publications
(335 reference statements)
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“…Figure 3B shows that the mean particle size of PAMAM-PEG-EpDT3/pMEG3 NPs was 180±0.15 nm with a polydispersity of 0.236 and zeta potential 19.7±0.23 mV ( Figure 3C). The appropriate particle size and zeta potential ensure that the NPs are enriched in tumor tissues through the enhanced permeability and retention effect (EPR) effect and taken up by tumor cells [31,32].…”
Section: Resultsmentioning
confidence: 99%
“…Figure 3B shows that the mean particle size of PAMAM-PEG-EpDT3/pMEG3 NPs was 180±0.15 nm with a polydispersity of 0.236 and zeta potential 19.7±0.23 mV ( Figure 3C). The appropriate particle size and zeta potential ensure that the NPs are enriched in tumor tissues through the enhanced permeability and retention effect (EPR) effect and taken up by tumor cells [31,32].…”
Section: Resultsmentioning
confidence: 99%
“…Folic acid (FA) [64,65], hyaluronic acid (HA) [33], specific ligands [66] are also often used as target tags. A recent focus on cell membrane and exosome permeability targeting needs to be mentioned [40,67,68]. Meanwhile, stimuli-responsive metallodrugs and metal-frameworks loaded with chemo-therapeutic drugs have been developing by virtue of the unique pathophysiological environment of tumor tissues [69].…”
Section: Tumor Chemotherapymentioning
confidence: 99%
“…One of the major concerns in cancer nanomedicine is the tumor targeting efficiency, which influences both therapeutic efficacy and biosafety in clinical applications. Tremendous efforts have been devoted to enhance tumor targeting efficiencies 75,76 . Among the various approaches, magnetic targeting is considered a promising approach that can be conducted in a spatiotemporal controllable manner 77 .…”
Section: Mions For Cancer Diagnosis and Therapymentioning
confidence: 99%