Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

Carpa, Rahela; Farkas, Anca; Dobrotă, Cristina; Butiuc-Keul, Anca

doi:10.3390/gels9040278

Cited by 15 publications

(7 citation statements)

References 197 publications

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“…This property makes it a reactive reagent suitable for many types of applications as a biomaterial, including its integration in nanocomposites. Materials containing chitosan are non-toxic, biocompatible, renewable, biodegradable and easy to model because they are based on maneuverable polymers [ 25 , 26 , 27 ]. Also, they have a high absorption rate; therefore, films, sponges, and hydrogels can be manufactured using chemical or green chemical syntheses.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles-Chitosan Nanocomposites: A Comparative Study Regarding Different Chemical Syntheses Procedures and Their Antibacterial Effect

Chicea,

Nicolae-Maranciuc,

Chicea

2024

Materials

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Nanocomposites based on silver nanoparticles and chitosan present important advantages for medical applications, showing over time their role in antibacterial evaluation. This work presents the comparative study of two chemical synthesis procedures of nanocomposites, based on trisodium citrate dihydrate and sodium hydroxide, using various chitosan concentrations for a complex investigation. The nanocomposites were characterized by AFM and DLS regarding their dimensions, while FT-IR and UV–VIS spectrometry were used for the optical properties and to reveal the binding of silver nanoparticles with chitosan. Their antibacterial effect was determined using a disk diffusion method on two bacteria strains, E. coli and S. aureus. The results indicate that, when using both methods, the nanocomposites obtained were below 100 nm, yet the antibacterial effect proved to be stronger for the nanocomposites obtained using sodium hydroxide. Furthermore, the antibacterial effect can be related to the nanocomposites’ sizes, since the smallest dimension nanocomposites exhibited the best bacterial growth inhibition on both bacteria strains we tested and for both types of silver nanocomposites.

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Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles-Chitosan Nanocomposites: A Comparative Study Regarding Different Chemical Syntheses Procedures and Their Antibacterial Effect

Chicea,

Nicolae-Maranciuc,

Chicea

2024

Materials

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“…Distinctly, chitosan-based hydrogels are promising matrices for the treatment of polluted waters due to characteristics such as good mechanical and thermal resistance, high chemical stability, and low price and due to the accessibility of recovery—reuse of both hydrogel and pollutants [ 68 , 69 , 70 , 71 ]. Also, the mechanical strength of chitosan-based hydrogels can be improved by adding nanoparticles or by crosslinking with synthetic polymers or biopolymers.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Hydrogels for Water Purification Applications

Chelu,

Musuc,

Popa

et al. 2023

Gels

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Chitosan-based hydrogels have gained significant attention for their potential applications in water treatment and purification due to their remarkable properties such as bioavailability, biocompatibility, biodegradability, environmental friendliness, high pollutants adsorption capacity, and water adsorption capacity. This article comprehensively reviews recent advances in chitosan-based hydrogel materials for water purification applications. The synthesis methods, structural properties, and water purification performance of chitosan-based hydrogels are critically analyzed. The incorporation of various nanomaterials into chitosan-based hydrogels, such as nanoparticles, graphene, and metal-organic frameworks, has been explored to enhance their performance. The mechanisms of water purification, including adsorption, filtration, and antimicrobial activity, are also discussed in detail. The potential of chitosan-based hydrogels for the removal of pollutants, such as heavy metals, organic contaminants, and microorganisms, from water sources is highlighted. Moreover, the challenges and future perspectives of chitosan-based hydrogels in water treatment and water purification applications are also illustrated. Overall, this article provides valuable insights into the current state of the art regarding chitosan-based hydrogels for water purification applications and highlights their potential for addressing global water pollution challenges.

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“…Biofilms and device-related infections are typically complex; therefore, it is advisable to select broad-spectrum antibacterial agents, a requirement satisfied by antimicrobial peptides (AMPs) and chitosan in some research studies [4,5]. AMPs are peptides that have developed in organisms ranging from prokaryotes to humans to give non-specific immune protection [6].…”

Section: Introductionmentioning

confidence: 99%

Self-Entrapment of Antimicrobial Peptides in Silica Particles for Stable and Effective Antimicrobial Peptide Delivery System

Ki,

Kim,

Park

et al. 2023

IJMS

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Antimicrobial peptides (AMPs) have emerged as a promising solution to tackle bacterial infections and combat antibiotic resistance. However, their vulnerability to protease degradation and toxicity towards mammalian cells has hindered their clinical application. To overcome these challenges, our study aims to develop a method to enhance the stability and safety of AMPs applicable to effective drug–device combination products. The KR12 antimicrobial peptide was chosen, and in order to further enhance its delivery and efficacy the human immunodeficiency virus TAT protein-derived cell-penetrating peptide (CPP) was fused to form CPP-KR12. A new product, CPP-KR12@Si, was developed by forming silica particles with self-entrapped CPP-KR12 peptide using biomimetic silica precipitability because of its cationic nature. Peptide delivery from CPP-KR12@Si to bacteria and cells was observed at a slightly delivered rate, with improved stability against trypsin treatment and a reduction in cytotoxicity compared to CPP-KR12. Finally, the antimicrobial potential of the CPP-KR12@Si/bone graft substitute (BGS) combination product was demonstrated. CPP-KR12 is coated in the form of submicron-sized particles on the surface of the BGS. Self-entrapped AMP in silica nanoparticles is a safe and effective AMP delivery method that will be useful for developing a drug–device combination product for tissue regeneration.

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Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

Cited by 15 publications

References 197 publications

Silver Nanoparticles-Chitosan Nanocomposites: A Comparative Study Regarding Different Chemical Syntheses Procedures and Their Antibacterial Effect

Silver Nanoparticles-Chitosan Nanocomposites: A Comparative Study Regarding Different Chemical Syntheses Procedures and Their Antibacterial Effect

Chitosan Hydrogels for Water Purification Applications

Self-Entrapment of Antimicrobial Peptides in Silica Particles for Stable and Effective Antimicrobial Peptide Delivery System

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