Double nanohole optical trapping: dynamics and protein-antibody co-trapping

Zehtabi-Oskuie, Ana; Jiang, Hao; Cyr, Bryce R.; Rennehan, Douglas; Al-Balushi, Ahmed A.; Gordon, Reuven

doi:10.1039/c3lc00003f

Cited by 51 publications

(52 citation statements)

References 28 publications

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“…Gordon and co‐workers employed double‐nanoholes on an Au thin film to trap dielectric nanoparticles with diameters down to 12 nm with a reduced light intensity . Recently, using the same plasmonic substrates, the Gordon group has successfully trapped a single protein and protein–antibody pairs …”

Section: Plasmon‐enhanced Functionalities In Microfluidicsmentioning

confidence: 99%

“…For example, Martin and co‐workers have achieved the simultaneous trapping and sensing of 10 nm particles with plasmonic nanoantennas . Based on the sensitivity of light transmission through the nanoapertures to the movement of nanoparticles, SIBA‐based plasmonic tweezers have also enabled simultaneous trapping and sensing …”

Section: Plasmon‐enhanced Functionalities In Microfluidicsmentioning

confidence: 99%

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Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

Wang

Zhao

Miao

et al. 2015

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Plasmofluidics is the synergistic integration of plasmonics and micro/nano fluidics in devices and applications in order to enhance performance. There has been significant progress in the emerging field of plasmofluidics in recent years. By utilizing the capability of plasmonics to manipulate light at the nanoscale, combined with the unique optical properties of fluids, and precise manipulation via micro/nano fluidics, plasmofluidic technologies enable innovations in lab-on-a-chip systems, reconfigurable photonic devices, optical sensing, imaging, and spectroscopy. In this review article, we examine and categorize the most recent advances in plasmofluidics into plasmon-enhanced functionalities in microfluidics and microfluidics-enhanced plasmonic devices. The former focuses on plasmonic manipulations of fluids, bubbles, particles, biological cells, and molecules at the micro-/nano-scale. The latter includes technological advances that apply microfluidic principles to enable reconfigurable plasmonic devices and performance-enhanced plasmonic sensors. We conclude with our perspectives on the upcoming challenges, opportunities, and the possible future directions of the emerging field of plasmofluidics.

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Section: Plasmon‐enhanced Functionalities In Microfluidicsmentioning

confidence: 99%

Section: Plasmon‐enhanced Functionalities In Microfluidicsmentioning

confidence: 99%

Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

Wang

Zhao

Miao

et al. 2015

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“…By optimizing the shape of the aperture to increase the field gradient, recent publications use the SIBA method to trap, e.g., 12nm dielectric spheres 10 and single proteins. 11 So far, the SIBA technique was demonstrated using a metallized glass slide with a milled aperture, usually as the top of a closed cell. Our intention is to develop a more versatile tool, enabling trapping with 3D positioning and small spatial footprint.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured fibre tip for trapping of nanoparticles

et al. 2014

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We propose to optically trap nanoparticles utilizing a single nanostructured glass-fiber tip. 3D translation of optically trapped nanoparticles -nano tweezers -presents vast application possibilities and has not yet been shown. The input end of the fibre probe is a standard fibre, providing easy coupling to a light source. The output end is tapered down and covered with gold, with a nanoaperture fabricated on the tip. The nanoaperture provides the strong field gradient necessary for trapping of nanoparticles. We discuss probe geometries supported by numerical simulations. The fabrication procedure for the fibre probe, using a focused ion beam, is described. A set-up for the experiments has been made and preliminary trapping results are presented.

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“…Reducing the laser intensity is important because it reduces the danger of photo damage. Furthermore, a double nanohole made of overlapping holes drilled on a gold substrate was used for trapping nanoparticles [13] and a single protein molecule [14, 15]. This method combined with the scattering signal measurements can also work as a sensor for size based characterization of nanoparticles [16].…”

Section: Introductionmentioning

confidence: 99%

Trapping of a single DNA molecule using nanoplasmonic structures for biosensor applications

Kim

Lee

2014

Biomed. Opt. Express

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Conventional optical trapping using a tightly focused beam is not suitable for trapping particles that are smaller than the diffraction limit because of the increasing need of the incident laser power that could produce permanent thermal damages. One of the current solutions to this problem is to intensify the local field enhancement by using nanoplasmonic structures without increasing the laser power. Nanoplasmonic tweezers have been used for various small molecules but there is no known report of trapping a single DNA molecule. In this paper, we present the trapping of a single DNA molecule using a nanohole created on a gold substrate. Furthermore, we show that the DNA of different lengths can be differentiated through the measurement of scattering signals leading to possible new DNA sensor applications.

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Double nanohole optical trapping: dynamics and protein-antibody co-trapping

Cited by 51 publications

References 28 publications

Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale

Nanostructured fibre tip for trapping of nanoparticles

Trapping of a single DNA molecule using nanoplasmonic structures for biosensor applications

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