Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications

Beaudette, Kathy; Li, Jiawen; Lamarre, Joseph; Majeau, Lucas; Boudoux, Caroline

doi:10.3390/bios12020090

Cited by 6 publications

(3 citation statements)

References 104 publications

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“…Optical imaging has played a crucial role in the life sciences, from providing insight into the cellular basis of tissue [ 3 ] through to visualizing cellular function, such as in neuronal networks [ 4 ]. The integration of these complementary modalities—sensing and imaging—within a single fiber allows for measurement of a range of physical and biological parameters while providing anatomical/morphological information [ 5 , 6 ]. It addresses an unmet demand for in vivo study of complex biological processes, which can be heterogenous in space and time and thus require simultaneous, co-located sensing and imaging measurements.…”

Section: Introductionmentioning

confidence: 99%

Single-fiber probes for combined sensing and imaging in biological tissue: recent developments and prospects

Li,

Warren-Smith,

McLaughlin

et al. 2024

Biomed. Opt. Express

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Single-fiber-based sensing and imaging probes enable the co-located and simultaneous observation and measurement (i.e., ‘sense’ and ‘see’) of intricate biological processes within deep anatomical structures. This innovation opens new opportunities for investigating complex physiological phenomena and potentially allows more accurate diagnosis and monitoring of disease. This prospective review starts with presenting recent studies of single-fiber-based probes for concurrent and co-located fluorescence-based sensing and imaging. Notwithstanding the successful initial demonstration of integrated sensing and imaging within single-fiber-based miniaturized devices, the realization of these devices with enhanced sensing sensitivity and imaging resolution poses notable challenges. These challenges, in turn, present opportunities for future research, including the design and fabrication of complex lens systems and fiber architectures, the integration of novel materials and other sensing and imaging techniques.

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Section: Introductionmentioning

confidence: 99%

Single-fiber probes for combined sensing and imaging in biological tissue: recent developments and prospects

Li,

Warren-Smith,

McLaughlin

et al. 2024

Biomed. Opt. Express

Self Cite

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“…Several extant fiber-based optical sensors can measure temperature, pressure, and strain only [ 21 , 27 , 28 ]. Hence, there is an opportunity to create a fiber sensor that utilizes a coagulation factor modality for clinical uses.…”

Section: Introductionmentioning

confidence: 99%

Fabry–Perot Interferometric Fiber-Optic Sensor for Rapid and Accurate Thrombus Detection

Ghasemi

Jeong

et al. 2023

Biosensors

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We present a fiber-optic sensor based on the principles of a Fabry–Perot interferometer (FPI), which promptly, sensitively, and precisely detects blood clot formation. This sensor has two types of sensor tips; the first was crafted by splicing a tapered fiber into a single-mode fiber (SMF), where fine-tuning was achieved by adjusting the tapered diameter and length. The second type is an ultra-compact blood FPI situated on the core of a single-mode fiber. The sensor performance was evaluated via clot-formation-indicating spectrum shifts induced by the varied quantities of a thrombin reagent introduced into the blood. The most remarkable spectral sensitivity of the micro-tip fiber type was approximately 7 nm/μL, with a power sensitivity of 4.1 dB/μL, obtained with a taper fiber diameter and length of 55 and 300 μm, respectively. For the SMF type, spectral sensitivity was observed to be 8.7 nm/μL, with an optical power sensitivity of 0.4 dB/μL. This pioneering fiber-optic thrombosis sensor has the potential for in situ applications, healthcare, medical monitoring, harsh environments, and chemical and biological sensing. The study underscores the scope of optical technology in thrombus detection, establishing a platform for future medical research and application.

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“…During the operation procedure, surgeons cannot recognize the precise status of the robots in an uncertain environment without the sensing capability. To improve surgical performance, medical robots or devices can be mounted with sensors to collect interaction or surrounding information, including contact force [ 16 , 17 , 18 ], surrounding temperature, vision [ 19 , 20 ], and geometrics or pathology inside the vessels [ 21 , 22 , 23 ]. Additionally, to detect diseases in their early stages before symptoms appear, it is significant to make deep tissue diagnoses.…”

Section: Introductionmentioning

confidence: 99%

Progress in Probe-Based Sensing Techniques for In Vivo Diagnosis

et al. 2022

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Advancements in robotic surgery help to improve the endoluminal diagnosis and treatment with minimally invasive or non-invasive intervention in a precise and safe manner. Miniaturized probe-based sensors can be used to obtain information about endoluminal anatomy, and they can be integrated with medical robots to augment the convenience of robotic operations. The tremendous benefit of having this physiological information during the intervention has led to the development of a variety of in vivo sensing technologies over the past decades. In this paper, we review the probe-based sensing techniques for the in vivo physical and biochemical sensing in China in recent years, especially on in vivo force sensing, temperature sensing, optical coherence tomography/photoacoustic/ultrasound imaging, chemical sensing, and biomarker sensing.

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Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications

Cited by 6 publications

References 104 publications

Single-fiber probes for combined sensing and imaging in biological tissue: recent developments and prospects

Single-fiber probes for combined sensing and imaging in biological tissue: recent developments and prospects

Fabry–Perot Interferometric Fiber-Optic Sensor for Rapid and Accurate Thrombus Detection

Progress in Probe-Based Sensing Techniques for In Vivo Diagnosis

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