Double-blind study of premature rupture of the membranes

Lebherz, Thomas B.; Hellman, Louis P.; Madding, Russell; Anctil, Arthur O.; Arje, S.L.

doi:10.1016/0002-9378(63)90502-7

Cited by 99 publications

(29 citation statements)

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“…Unfortunately they are not sensitive enough for routine clinical use 14 . Maternal infection after PROM may be severe and has an overall mortality rate of 1 in 5400 15 .…”

Section: Introductionmentioning

confidence: 99%

Fetal outcome of pre-labor rupture of membranes

Shrestha

Sharma

1970

Nepal j. obstet. gynaecol.

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Abstract:Objective: Objective: Objective: Objective: Objective: To study the determinants and outcome of prelabour rupture of membrane at term pregnancy in Patan Hospital. Method:Method: Method: Method: Method: A prospective, hospital based case control study done in maternity ward of Patan Hospital over the period of three months (Poush 2059-Phalgun 2059). A total no of 100 pregnant women with prelabor rupture of membrane and 100 pregnant women without prelabor rupture of membrane were included in this study. Results:Results: Results: Results: Results: The incidence of pre labor rupture of membrane in this study was 6.06%. Major risk factors for prelabor rupture of membranes were antecedent coitus, hydramnious, smoking, cephalo-pelvic disproportion, and previous abortion. Normal delivery occurred in 70% in prelabor rupture of membrane group and in 93 % in non-prelabor rupture of membrane group. Forty-nine pregnant women with pre-labour rupture of membrane received antibiotics and twenty-four babies (48.98%) developed neonatal infection in pre-labour rupture of membrane group and only one developed infection in non-prelabour rupture. Four cases of neonatal infection was seen in neonates born from mothers with prelabor rupture of membranes < 24 hours and 20 cases of neonatal infection were seen in those neonates born from mother with pre-labor rupture of membrane >24 hours (p <0.05). Conclusion Conclusion ConclusionConclusion Conclusion: Neonatal morbidity increases with the increase of time interval between the rupture of membrane and delivery and antibiotics given to mother of PROM does not totally protect neonates from infection.

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“…Unfortunately they are not sensitive enough for routine clinical use 14 . Maternal infection after PROM may be severe and has an overall mortality rate of 1 in 5400 15 .…”

Section: Introductionmentioning

confidence: 99%

Fetal outcome of pre-labor rupture of membranes

Shrestha

Sharma

1970

Nepal j. obstet. gynaecol.

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“…So, the apparent increase in intrapartum fetal distress in PROM cases compared to controls is not statistically significant. [2][3][4][5][6] This study shows that majority of patients with PROM have latent period <24 hrs (Table 1).…”

Section: Latent Period <24 Hrsmentioning

confidence: 99%

A study on management of premature rupture of membranes

Mondal

Kanoongo

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Premature rupture of membranes (PROM) is a common obstetric complication. Knowledge of etiopathogenesis, diagnosis, complications and management of PROM has significantly increased due to extensive research in the recent past. Yet, there is no unanimous opinion regarding optimum management of PROM. The aim of the study was to observe the patients during labor and compare the latent period, duration of first stage of labor, modes of deliveries and the use of oxytocin and its outcome in PROM cases with controls. The study has been conducted with the belief that these data will help in better management of PROM cases in future.Methods: In this study, the definition of PROM adopted is rupture of fetal membranes before the onset of true labor pain. The minimum gestational age was taken to be 28 weeks. Diagnosis of PROM was mainly clinical. Patients were monitored during the latent period and during labor. Induction of labor was done where necessary. Collected data were analysed using Chi Square Test.Results: It was observed that onset of labor was more rapid with increasing gestational age. Use of oxytocin for induction and augmentation of labor and operative deliveries were higher in PROM cases. These results mostly corroborated with the findings of other researchers.Conclusions: The conclusion drawn at the end of the study was that individualized management of PROM cases depending on the gestational age and risk of complications is the best way to achieve a good fetomaternal outcome.

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“…Although several trials have shown a beneficial effect of prophylactic antibiotic therapy on maternal -fetal outcome, however the optimal drug or combination of drugs, route of administration, and duration of therapy are yet to be determined [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Because of the variety of potential pathogens colonizing the vagina (and possibly the amnion after membrane rupture), broad-spectrum antibiotics offer some theoretical advantages over narrow-spectrum agents.…”

Section: Introduction:-mentioning

confidence: 99%