Double-Blind, Placebo-Controlled Study of Single-Dose Amphetamine Formulations in ADHD

James, Regina S.; Sharp, Wendy; Bastain, Theresa M.; Lee, Patti P.; Walter, James M.; Czarnolewski, Mark Y.; Castellanos, F. Xavier

doi:10.1097/00004583-200111000-00006

Cited by 76 publications

(45 citation statements)

References 17 publications

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“…62 In this study, children who received DEX in combination with academic instruction and therapeutic recreation had better behaviour than those in the nonintervention group when assessed using the CTRS and the Children's Psychiatric Rating Scale, but not when assessed using the CPRS. No studies in this category evaluated CGI.…”

Section: Discussionmentioning

confidence: 60%

“…62 In this study, DEX-SR in combination with formal academic instruction and therapeutic recreation resulted in improved behaviour compared with non-drug intervention alone. Owing to the poor reporting of some methodological criteria, the results from this study should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 64%

“…One study compared DEX in combination with a non-drug treatment (academic instruction and therapeutic recreation) with nondrug treatment alone with hyperactivity as an outcome. 62 Results were significant in favour of the combined treatment group when assessed using the CTRS and the Children's Psychiatric Rating Scale, but not when assessed using the CPRS. CGI was not examined.…”

Section: Dex Versus Placebomentioning

confidence: 89%

“…James and colleagues 62 evaluated hyperactivity using three different scales. In this crossover study, immediate-release DEX was administered once weekly in addition to formal academic instruction and therapeutic recreation (e.g.…”

Section: Hyperactivitymentioning

confidence: 99%

“…No data reported in James and colleagues' trial 62 could usefully contribute to the analysis of adverse events. …”

Section: Adverse Eventsmentioning

confidence: 99%

See 4 more Smart Citations

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

King

Griffin²,

Hodges³

et al. 2006

Health Technol Assess

144

117

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA Programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS,...

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 64%

Section: Dex Versus Placebomentioning

confidence: 89%

Section: Hyperactivitymentioning

confidence: 99%

“…No data reported in James and colleagues' trial 62 could usefully contribute to the analysis of adverse events. …”

Section: Adverse Eventsmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

King

Griffin²,

Hodges³

et al. 2006

Health Technol Assess

144

117

View full text Add to dashboard Cite

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Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents

Punja

Shamseer

Hartling

et al. 2016

Cochrane Database of Systematic Reviews

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Attention‐Deficit/Hyperactivity Disorder

2006

Wiley Handbook of Current and Emerging Drug Therapies

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ABSTRACT. A 3-year-old child was referred to consultation for hyperactivity, attention deficit, impulsivity, and sleep problems. He met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for attentiondeficit/hyperactivity disorder. At baseline, the Conners' Parent Rating Scale and the Conners' Teacher Rating Scale raw total scores were 30 and 32, respectively. The child had low a serum ferritin level (13 ng/mL). After 8 months of treatment with Tardyferon (ferrous sulfate, 80 mg/day), his serum ferritin increased to 102 ng/mL. Both parents and teachers reported considerable behavioral improvement. The Conners' Parent and Teacher Rating Scale raw total scores decreased to 19 and 13, respectively. This is the first report of the effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder. P reliminary evidence supports a significant iron deficiency in children with attention-deficit/ hyperactivity disorder (ADHD). 1 The symptoms of ADHD may be related to a dopamine dysfunction or to an imbalance in dopaminergic function. [2][3][4][5] Iron is a cofactor for tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis. Moreover, iron deficiency has been described to alter dopamine D 1 and D 2 receptor density and activity in animals. 6,7 Therefore, brain iron stores might influence dopamine-dependent functions and, consequently, the expression of ADHD symptoms.Previous neuropsychological studies reported an improvement in children' s attention span after iron supplementation. 8,9 However, no study thus far has addressed specifically the effectiveness of iron supplementation in iron-deficient children with ADHD diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. 10 This study reports on the effect of iron supplementation in a 3-year-old child with ADHD. CASE REPORTA 3-year-old male was referred to the outpatient clinic of the child psychopathology unit for symptoms of inattention, hyperactivity, and impulsivity at school and home.His father, a 28-year-old-employee, presented with symptoms of inattention and impulsivity. In childhood, he also was hyperactive. These symptoms caused a functional impairment first at school and subsequently in his work and social life. Therefore, the father was very worried about the symptomatology presented by his son. The mother, a 29-year-old housewife, reported no relevant psychiatric symptoms. The child was the only son in the family. No other relevant psychiatric symptoms or disorders in the family were reported. No medical problems during pregnancy or after the birth of the child were reported. The physical and neurologic development of the child was normal. At the time of the consultation, the child was in his first year of kindergarten. After consultation with the teachers, who also were very worried about the behavior of the child at school, the parents decided to come to our unit.Although the diagnosis of ADHD in preschoolers is complex an...

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Double-Blind, Placebo-Controlled Study of Single-Dose Amphetamine Formulations in ADHD

Cited by 76 publications

References 17 publications

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents

Attention‐Deficit/Hyperactivity Disorder

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