A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents

Abstract

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA Programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS,...

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions

“…An initial interpretation of the behavioral data suggested that the animals lacking cerebral adm may be suffering a syndrome similar to the human attention deficit hyperactivity disorder (ADHD). Patients affected by ADHD are successfully treated with methylphenidate and other psychostimulants (20), which produce the paradoxical effect of bringing down the activity levels. To investigate whether our mice were sensitive to these drugs, we injected knockout and control mice with methylphenidate and measured their behavior on the activity cage at different times after treatment ( Fig.…”

Cost-utility analysis of methylphenidate treatment for children and adolescents with ADHD in Brazil

“…Furthermore, the model adopted in this study was more complete than those used in previous investigations. 16,18 Second, the high ICER values for treatment success could be even higher than those presented in this analysis. Due to the high dropout rates, most patients may leave treatment, for a variety of reasons, including lack of efficacy.…”

“…In contrast, countries like the UK, 16 the U.S., 17 Australia, 18 and Spain 19 are largely focusing on economic analysis and health policy for ADHD treatment. To date, a systematic review found 14 studies from different countries on the theme.…”

Peculiaridades del Consentimiento Informado en Salud Mental. Considerando el Caso TDA/H como Ejemplo

“…De los metanálisis y revisiones sistemáticas consultadas, sólo Drug ERPO (McDonagh, Peterson, Dana y Takhurta, 2011) y King et al (2006) consideran aspectos de funcionalidad, indicando la ausencia de beneficios. Otro tipo de fuentes intuyen problemas de funcionalidad y discapacidad social (Whitaker, 2010).…”