Double-blind comparison of a dithranol and steroid mixture with a conventional dithranol regimen for chronic psoriasis

Abstract

Twenty four of 30 patients with chronic plaque psoriasis completed a double-blind randomized paired comparison of dithranol in Lassar's paste versus dithranol and fluocinonide in Lassar's paste. There was a more rapid reduction in severity of the psoriasis on the side treated with the dithranol and fluocinonide mixture, but no difference in the final time to clearance between the two sides. There were fewer burning episodes on the side treated with dithranol and fluocinonide and greater staining of the skin. Of the 20 patients who were subsequently followed up for up to 3 months, 11 had relapsed more on the side treated with dithranol and fluocinonide, two on the side treated with dithranol alone and in seven there was no appreciable difference. It was concluded that the addition of a topical steroid to a conventional dithranol regimen produced more rapid initial clearance and less burning, but more rapid relapse of the psoriasis.

Combinations of classical time‐honoured topicals in plaque psoriasis: a systematic review

“…No perilesional erythema was reported. Two other papers concluded that the combination of dithranol with a mid‐potent 47 or with a potent corticosteroid 46 respectively showed no significant differences compared to dithranol monotherapy. In the latter open clinical study 46 dithranol monotherapy was compared to combination therapy of dithranol with mometasone and to a combination regimen with dithranol and calcipotriol ointment.…”

Mometason und Calcipotriol optimieren den therapeutischen Initialeffekt von Dithranol auf die chronisch stationäre Psoriasis (CSP)

“…Eine andere Arbeitsgruppe [7] berichtete allerdings während eines Nachbeobachtungszeitraums von 3 Monaten über höhere Rezidivraten bei einem mit einer Fluocinolon-Dithranol-Kombination behandelten Psoriasiskollektiv im ten die Therapie wegen periläsionaler toxischer Dermatitiden unterbrechen.…”

The influence of a topical corticosteroid on short-contact high-dose dithranol therapy

“…Grattan et al . noted a faster improvement early during treatment, while the total treatment period was equal in patients treated with dithranol only or with dithranol combined with a corticosteroid 14 . Runne and Kunze did not observe a better therapeutic result with the combination of dithranol and corticosteroids 15 .…”

“…13 Grattan et al noted a faster improvement early during treatment, while the total treatment period was equal in patients treated with dithranol only or with dithranol combined with a corticosteroid. 14 Runne and Kunze did not observe a better therapeutic result with the combination of dithranol and corticosteroids. 15 Mahrle and Schulze demonstrated that pretreatment with topical corticosteroids for 1 week reduced the response to dithranol and the duration of remission.…”