Mometason und Calcipotriol optimieren den therapeutischen Initialeffekt von Dithranol auf die chronisch stationäre Psoriasis (CSP)

Sander, P.; Stücker, Markus; Hermes, Nico; Hoffmann, Klaus; Altmeyer, Peter

doi:10.1007/s001050050743

Cited by 13 publications

(9 citation statements)

References 8 publications

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“…Therefore, it seems reasonable to assume that calcipotriol is capable of causing a continuous augmentation of the antipsoriatic effects of dithranol that leads to a rapid healing of psoriatic plaques with a significant reduction in the length of the treatment period and consequently to a better patient compliance. The discrepancy between our results and those of Sander et al [17] is most probably due to the obvious marked differences in the design and methods of the two studies. Table 3 summarizes the data originating from a group of inpatients with chronic plaque psoriasis (with PASI scores comparable with those of the patients of the present study) who had been treated in our Department with calcipotriol (ointment) monotherapy for 6 weeks.…”

Section: Discussioncontrasting

confidence: 57%

“…In a recent open clinical trial, Sander et al [17] reported that addition of calcipotriol ointment (once daily) to conventional dithranol application results in an enhancement of the therapeutic efficacy of the latter in chronic plaque psoriasis only in the initial phase of the treatment, whereas by the end of the trial, no significant differences were found by these authors between the combined regimen and dithranol monotherapy with regard to therapeutic efficacy.…”

Section: Discussionmentioning

confidence: 86%

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Calcipotriol Plus Short-Contact Dithranol: A Novel Topical Combination Therapy for Chronic Plaque Psoriasis

Monastirli

Georgiou

Pasmatzi

et al. 2002

Skin Pharmacol Physiol

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The purpose of this double-blind randomised parallel-group study was to compare the efficacy and safety of short-contact treatment with dithranol ointment (2%) with its combination with calcipotriol ointment (50 µg/g) in 2 groups of in-patients with chronic plaque psoriasis. The patients of the first group (n = 23) topically applied dithranol once daily for 30 min and the vehicle of calcipotriol twice daily. The patients of the second group (n = 23) used a single topical application of dithranol for 30 min daily and additionally applied calcipotriol twice daily. The extent and the severity of psoriasis were assessed by means of psoriasis area and severity index score (PASI score) before the onset of the 6-week therapy and weekly thereafter. The difference between the two groups with regard to the mean PASI score became statistically significant already after the first week of treatment and remained so until the end of the trial. No significant differences were observed between the two groups with respect to the cutaneous adverse events. These findings indicate that the addition of calcipotriol ointment to short-contact dithranol markedly augments the therapeutic efficacy of the latter in chronic plaque psoriasis and impressively accelerates the response of psoriatic plaques to this well-tolerated regimen.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 86%

Calcipotriol Plus Short-Contact Dithranol: A Novel Topical Combination Therapy for Chronic Plaque Psoriasis

Monastirli

Georgiou

Pasmatzi

et al. 2002

Skin Pharmacol Physiol

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“…Two other papers concluded that the combination of dithranol with a mid‐potent 47 or with a potent corticosteroid 46 respectively showed no significant differences compared to dithranol monotherapy. In the latter open clinical study 46 dithranol monotherapy was compared to combination therapy of dithranol with mometasone and to a combination regimen with dithranol and calcipotriol ointment. Adding calcipotriol to conventional dithranol application resulted in an enhancement of the therapeutic efficacy.…”

Section: Resultsmentioning

confidence: 99%

“…Literature search revealed eight studies on the combination of dithranol and topical corticosteroids [41][42][43][44][45][46][47][48] and two on dithranol combined with vitamin D analogues. 46,49 Three papers were excluded because results were on other types of psoriasis and other localized skin diseases, 41,44,45 one because demographic data were lacking, 48 and one paper was excluded because the treatment strategy was unclear. 43 Results show that the added value of a topical corticosteroid to dithranol therapy is related to steroid-potency.…”

Section: Dithranol Combined With Topical Corticosteroids or Vitamin Dmentioning

confidence: 99%

Combinations of classical time‐honoured topicals in plaque psoriasis: a systematic review

Hendriks¹,

Keijsers

Jong

et al. 2012

Acad Dermatol Venereol

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Methods of classical treatments are not standardized and different protocols in different treatment settings are used. Therefore the interpretation of study results cannot be generalized. Most evidence was found to recommend the use of a combination regimen of topical corticosteroids and salicylic acid, above monotherapy with either component. Also, the combinations of dithranol with superpotent corticosteroids or with coal tar may be preferred above both monotherapies. In case first-line treatments and systemic therapies are not effective or contraindicated, combinations of classical topicals may provide an important opportunity.

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“…One factor that is common to these topical agents is a significant potential for causing irritation [1]. It has been proven possible to reduce the risk of such undesirable effects by combining various topical agents or topical and systemic antipsoriatics and, at the same time, to reduce the costs of treatment [2, 3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Vitamin B<sub>12</sub> Cream Containing Avocado Oil in the Therapy of Plaque Psoriasis

et al. 2001

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Background: There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects. Objective and Methods: In this randomized, prospective clinical trial, the effects of the vitamin D₃ analog calcipotriol were evaluated against those of a recently developed vitamin B₁₂ cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography. Results: There was a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p < 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B₁₂ cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B₁₂ preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B₁₂ cream containing avocado oil as significantly better in comparison with that of calcipotriol. Conclusion: The results of this clinical trial provide evidence that the recently developed vitamin B₁₂ cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.

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Mometason und Calcipotriol optimieren den therapeutischen Initialeffekt von Dithranol auf die chronisch stationäre Psoriasis (CSP)

Cited by 13 publications

References 8 publications

Calcipotriol Plus Short-Contact Dithranol: A Novel Topical Combination Therapy for Chronic Plaque Psoriasis

Calcipotriol Plus Short-Contact Dithranol: A Novel Topical Combination Therapy for Chronic Plaque Psoriasis

Combinations of classical time‐honoured topicals in plaque psoriasis: a systematic review

Vitamin B<sub>12</sub> Cream Containing Avocado Oil in the Therapy of Plaque Psoriasis

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