The present study with a psychiatric-cytogenetic investigation of a 67-yearold woman with a chromosome mosaic of 45/46/47 chromosomes and sex chromosomes XO/xx/XXX is part of a more comprehensive study of intelligence, personality and mental disorders in patients with different chromosome abnormalities. Such studies may add to our knowledge of the genetic influence of specific chromosomes on personality, intelligence and mental disorders.
Patients with chromosome mosaics 45/47, XOIXXX and 45/46/47, X O l X X l X X Xyacobs et al. (1960) described a 42-year-old female patient with 45/47 chromosomes and sex chromosomes XO/xxX. Her father was 30 and her mother 32 when she was born, and she was number five of six siblings. She had never menstruated, and she had no breast development, she had comparatively broad shoulders and an android pelvis. The authors mentioned that her attitudes were feminine, and that she was of low normal intelligence. The external genitalia were underdeveloped with the exception of the clitoris. The labia majora were small, and the labia minora vestigal. She measured 156 cm. and had pigmented naevi on her face and neck, but no other stigmata of Turner's syndrome. Vagina was absent, and no uterus was palpable.Grumbach & Morishima (1961) described a 13-year-old girl with 45/46/47 chromosomes and sex chromosomes X0RoI;IxXX. She was short of stature and sexually infantile, but she had no webbing of the neck. She was described as being of average intelligence. Hayward & Cameron (1961) studied a 10-year-old girl with 45/46/47 chromosomes and sex chromosomes XO/xx/ XXX. At 7 her I.Q. was 64. She was short and slim with bird-like features.There was a wide separation of the nipples and syndactyly of the middle three toes of both feet. The genitalia were normal for a prepubertal girl, and