Dosing time-dependent variation of bone resorption by cyclosporin A in rats’ femurs

Tsuruoka, Shuichi; Kaneda, Tae; Maeda, Akimitsu; Ioka, Takashi; Fujimura, Akio

doi:10.1016/j.ejphar.2007.02.007

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Additionally, after studying the femurs of rats treated with 3 mg/kg ciclosporin once daily, Tsuruoka et al. 51 concluded that ciclosporin induced bone resorption and increased serum calcium and phosphate concentrations varied with the ciclosporin dosing time.…”

Section: Discussionmentioning

confidence: 99%

Ciclosporin therapy is associated with minimal changes in calcium metabolism in dogs with atopic dermatitis

Kovalik

Mellanby

Evans

et al. 2012

Veterinary Dermatology

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Section: Discussionmentioning

confidence: 99%

Ciclosporin therapy is associated with minimal changes in calcium metabolism in dogs with atopic dermatitis

Kovalik

Mellanby

Evans

et al. 2012

Veterinary Dermatology

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“…Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes intracellular protein that participates in the induction of differentiation and proliferation of T lymphocytes. 5,6 However, the use of cyclosporine A has also been related to the reduction of the expression of proteins related to the formation and maturation of bone tissue, 7,8 reduction of vitamin D levels, 7 reduction of osteoblastic differentiation and activity, 6,9 and an increased number of osteoclasts. 10 These effects of cyclosporine A may induce imbalance of bone turnover and, consequently, lead to a reduction of bone mineral density, 11 and fractures of the long bones.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes

et al. 2020

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The aim of this study was to assess the influence of cyclosporine administration on the repair of critical-sized calvaria defects (CSDs) in rat calvaria filled with diverse biomaterials. Sixty animals were divided into two groups: the control (CTR) group (saline solution) and the cyclosporine (CCP) group (cyclosporine, 10 mg/kg/day). These medications were administered daily by gavage, beginning 15 days before the surgical procedure and lasting until the day the animals were euthanized. A CSD (5 mm Ø) was made in the calvaria of each animal, which was allocated to one of 3 subgroups, according to the biomaterial used to fill the defect: coagulum (COA), deproteinized bovine bone (DBB), or biphasic calcium phosphate ceramics of hydroxyapatite and β-phosphate tricalcium (HA/TCP). Euthanasia of the animals was performed 15 and 60 days after the surgical procedure (n = 5 animals/period/ subgroup). Bone repair (formation) assessment was performed through microtomography and histometry, while the analyses of the expression of the BMP2, Osteocalcin, and TGFβ1 proteins were performed using immunohistochemistry. The CSDs not filled with biomaterials demonstrated lower bone formation in the CCP group. At 15 days, less bone formation was observed in the CSDs filled with DBB, a smaller volume of mineralized tissue was observed in the CSDs filled with HA/TCP, and the expression levels of BMP2 and osteocalcin were lower in the CCP group compared to the CTR group. The use of cyclosporine impaired bone repair in CSD, and this effect can be partially explained by the suppression of BMP2 and osteocalcin expression.

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Effects of bisphosphonate treatment on bone repair under immunosuppression using cyclosporine A in adult rats

et al. 2007

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Dosing time-dependent variation of bone resorption by cyclosporin A in rats’ femurs

Cited by 5 publications

References 27 publications

Ciclosporin therapy is associated with minimal changes in calcium metabolism in dogs with atopic dermatitis

Ciclosporin therapy is associated with minimal changes in calcium metabolism in dogs with atopic dermatitis

Cyclosporine A impairs bone repair in critical defects filled with different osteoconductive bone substitutes

Effects of bisphosphonate treatment on bone repair under immunosuppression using cyclosporine A in adult rats

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