Dosing-time dependent oxidative effects of an immunosuppressive drug “Mycophenolate Mofetil” on rat kidneys

Dridi, Ichrak; Ben-Cherif, Wafa; Chahdoura, Hassiba; Haouas, Zohra; Ben‐Attia, Mossadok; Aouam, Karim; Reinberg, Alain; Boughattas, Naceur A.

doi:10.1016/j.biopha.2016.12.087

Cited by 5 publications

(2 citation statements)

References 58 publications

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“…For example, Long et al [36] show that administration of hepatitis A and flu vaccines, respectively, in the morning yielded the highest antibody titres compared with at other times. In a study of the immunosuppressive mycophenolate mofetil (MMF) in Wistar rats, Dridi et al [37] found that the level of renal toxicity was a function of the time of day of administration. This latter finding is of particular importance to type 1 diabetes since MMF has been previously tested in combination with daclizumab as a treatment for recent-onset type 1 diabetes [38].…”

Section: Discussionmentioning

confidence: 99%

Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes

et al. 2021

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Aims/hypothesis The circadian clock influences both diabetes and immunity. Our goal in this study was to characterise more thoroughly the circadian patterns of immune cell populations and cytokines that are particularly relevant to the immune pathology of type 1 diabetes and thus fill in a current gap in our understanding of this disease. Methods Ten individuals with established type 1 diabetes (mean disease duration 11 years, age 18–40 years, six female) participated in a circadian sampling protocol, each providing six blood samples over a 24 h period. Results Daily ranges of population frequencies were sometimes large and possibly clinically significant. Several immune populations, such as dendritic cells, CD4 and CD8 T cells and their effector memory subpopulations, CD4 regulatory T cells, B cells and cytokine IL-6, exhibited statistically significant circadian rhythmicity. In a comparison with historical healthy control individuals, but using shipped samples, we observed that participants with type 1 diabetes had statistically significant phase shifts occurring in the time of peak occurrence of B cells (+4.8 h), CD4 and CD8 T cells (~ +5 h) and their naive and effector memory subsets (~ +3.3 to +4.5 h), and regulatory T cells (+4.1 h). An independent streptozotocin murine experiment confirmed the phase shifting of CD8 T cells and suggests that circadian dysrhythmia in type 1 diabetes might be an effect and not a cause of the disease. Conclusions/interpretation Future efforts investigating this newly described aspect of type 1 diabetes in human participants are warranted. Peripheral immune populations should be measured near the same time of day in order to reduce circadian-related variation. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes

et al. 2021

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“…Protein carbonyl content (PCO) is an important parameter for evaluation of oxidative damage to proteins. Protein carbonyl content represents an irreversible protein modification, often leading to the inactivation of the proteins and it is a sensitive and an early marker of oxidative stress to tissues 14 .…”

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An experimental study of ascorbic acid effects in acute renal failure under general anesthesia

et al. 2017

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Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15 th minute of inhalation anesthesia. Biochemical parameters consisted of serum levels of blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), and protein carbonyl content. Histopathological variables were tubular necrosis, fibrin, and cast formation. Results: NGAL levels were significantly lower in Group III than Group II and Group I. On the other hand, TAC, PCO, urea and creatinine levels were notably higher in Group I compared with Groups II and III. There was a significant difference between 3 groups on frequencies of acute tubular necrosis (p=0.003), fibrin (p<0.001) and cast (p<0.001). Acute tubular necrosis and fibrin formation were more prominent in Group I. Casts were more common in Groups II and III. Conclusions: The ascorbic acid serve as a prophylactic agent against renal damage in patients receiving sevoflurane anesthesia and higher doses were associated with more apparent protective effects.

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Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment

Lavallaz

Musso

2018

Int Urol Nephrol

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Dosing-time dependent oxidative effects of an immunosuppressive drug “Mycophenolate Mofetil” on rat kidneys

Cited by 5 publications

References 58 publications

Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes

Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes

An experimental study of ascorbic acid effects in acute renal failure under general anesthesia

Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment

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