Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy

Fogliata, Antonella; Scorsetti, Marta; Navarria, Pierina; Catalano, M.; Clivio, Alessandro; Cozzi, Luca; Lobefalo, F.; Nicolini, G.; Palumbo, V.; Pellegrini, Chiara; Reggiori, G.; Roggio, A.; Vanetti, Eugenio; Alongi, Filippo; Pentimalli, S.; Mancosu, P.

doi:10.3109/0284186x.2012.689853

Cited by 34 publications

(18 citation statements)

References 33 publications

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“…Such difference is of essential importance for dose in bone. Fogliata et al (35) compared the two types of AXB calculation with AAA in VMAT treatment plans for leg sarcoma cases and found that dose‐to‐water scheme on average overestimate dose in bone by

\sim 5 %

compared to dose‐to‐medium and AAA. In theory, the dose‐to‐medium calculation better reflects the physical cross sections of the photon and electron interactions with matter, and has shown to have better agreement with conventional “rescaled‐to‐water” calculation (AAA and CCC) (21) …”

Section: Discussionmentioning

confidence: 99%

Dosimetric comparison of Acuros XB with collapsed cone convolution/superposition and anisotropic analytic algorithm for stereotactic ablative radiotherapy of thoracic spinal metastases

Zhen

Hrycushko

Lee

et al. 2015

J Applied Clin Med Phys

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The aim of this study is to compare the recent Eclipse Acuros XB (AXB) dose calculation engine with the Pinnacle collapsed cone convolution/superposition (CCC) dose calculation algorithm and the Eclipse anisotropic analytic algorithm (AAA) for stereotactic ablative radiotherapy (SAbR) treatment planning of thoracic spinal (T‐spine) metastases using IMRT and VMAT delivery techniques. The three commissioned dose engines (CCC, AAA, and AXB) were validated with ion chamber and EBT2 film measurements utilizing a heterogeneous slab‐geometry water phantom and an anthropomorphic phantom. Step‐and‐shoot IMRT and VMAT treatment plans were developed and optimized for eight patients in Pinnacle, following our institutional SAbR protocol for spinal metastases. The CCC algorithm, with heterogeneity corrections, was used for dose calculations. These plans were then exported to Eclipse and recalculated using the AAA and AXB dose calculation algorithms. Various dosimetric parameters calculated with CCC and AAA were compared to that of the AXB calculations. In regions receiving above 50% of prescription dose, the calculated CCC mean dose is 3.1%–4.1% higher than that of AXB calculations for IMRT plans and 2.8%–3.5% higher for VMAT plans, while the calculated AAA mean dose is 1.5%–2.4% lower for IMRT and 1.2%–1.6% lower for VMAT. Statistically significant differences (p<0.05) were observed for most GTV and PTV indices between the CCC and AXB calculations for IMRT and VMAT, while differences between the AAA and AXB calculations were not statistically significant. For T‐spine SAbR treatment planning, the CCC calculations give a statistically significant overestimation of target dose compared to AXB. AAA underestimates target dose with no statistical significance compared to AXB. Further study is needed to determine the clinical impact of these findings.PACS number: 87.55.D‐, 87.53.Ly

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\sim 5 %

Section: Discussionmentioning

confidence: 99%

Dosimetric comparison of Acuros XB with collapsed cone convolution/superposition and anisotropic analytic algorithm for stereotactic ablative radiotherapy of thoracic spinal metastases

Zhen

Hrycushko

Lee

et al. 2015

J Applied Clin Med Phys

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show abstract

“…Kan et al 34 reported that, in comparison to the AXB_Dm, the AXB_Dw will calculate higher mean PTV doses by up to 4% and higher mean doses to the tissues adjacent to bone by up to about 2% for nasopharygeal carcinoma. Fogliata et al 35 reported that the dose distributions calculated by the AXB_Dw were about 5% higher than corresponding ones calculated by the AXB_Dm for soft-tissue sarcoma patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical dosimetric impact of Acuros XB and analytical anisotropic algorithm (AAA) on real lung cancer treatment plans : review

Rana

2014

Int J Cancer Ther Oncol

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Photon dose calculation algorithms in treatment planning system could affect the accuracy of dose delivery when tissue heterogeneity is involved along the beam path. Treatment planning for lung cancer is challenging, especially in the case of treatment plan involving small fields. The combination of low-density (air) medium and small fields cause charge particle disequilibrium nears the air/tissue interface. Beam modeling within the dose calculation algorithms must also employ an accurate method of accounting tissue heterogeneity corrections in order to avoid dose overestimation or underestimation. Analytical anisotropic algorithm (AAA) is one of the widely tested and validated dose calculation algorithms in external beam photon radiation therapy. Recently, Acuros XB (AXB) was made available for photon dose calculations, and several studies have demonstrated better dose prediction accuracy of the AXB over AAA. This article reviews the results from the treatment planning studies, which have investigated the clinical dosimetric impact of the AXB and AAA on real lung cancer treatment plans.

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“…The only DVH parameter value for OARs that was predicted to be higher by the AXB10 was the maximum lung dose. Fogliata et al 56 performed a dosimetric comparison between the AXB11, the AAA and proton radiotherapy for soft-tissue sarcoma. No clear differences were observed in the PTV dose distributions between the AXB11 and the AAA, though the number of needed monitor units by the AXB11 was 1.8% higher.…”

Section: The Axb Algorithm and Patient Plansmentioning

confidence: 99%

The accuracy of the Acuros XB algorithm in external beam radiotherapy – a comprehensive review

Ojala

2014

Int J Cancer Ther Oncol

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Review Article AbstractThe accuracy of dose calculation algorithms has been a topic of interest among the radiotherapy community throughout last decades. On one hand the advancements in computers and algorithms has improved the accuracy, but on the other hand the developments in other parts of treatment process, in treatment delivery techniques and in treatment devices have always pushed the requirements to the next level. In this review article a comprehensive overview on the accuracy of a new type 'c' dose calculation algorithm, the Acuros XB (AXB) algorithm (Varian Medical Systems, Inc., Palo Alto, CA, USA), is provided. All the articles that have applied the AXB algorithm in terms of external beam radiotherapy are included and the research frames with reported deviations to reference methods are described. For the homogeneous water phantoms the reported accuracy was from 1% to 2%, being of similar level for heterogeneous phantoms, in rare occasions lower. In anthropometric and anthropomorphic phantoms the mean deviations were about 2% and slightly larger for single points and/or small regions. With patient plans the reported average discrepancies were less than from 3% to 5%. Almost without exceptions, the algorithm has proven to perform better than other existing commercial dose calculation algorithms. The number of such papers, in which the AXB algorithm is the only dose determination method, is already notable, which indicates that the accuracy of the algorithm is trusted for reference use and it also, with reported dosimetric results, implies that the AXB algorithm has reached its maturity.

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Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy

Abstract: (2013) Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy, Acta Oncologica, 52:3, 545-552,

Cited by 34 publications

References 33 publications

Dosimetric comparison of Acuros XB with collapsed cone convolution/superposition and anisotropic analytic algorithm for stereotactic ablative radiotherapy of thoracic spinal metastases

Dosimetric comparison of Acuros XB with collapsed cone convolution/superposition and anisotropic analytic algorithm for stereotactic ablative radiotherapy of thoracic spinal metastases

Clinical dosimetric impact of Acuros XB and analytical anisotropic algorithm (AAA) on real lung cancer treatment plans : review

The accuracy of the Acuros XB algorithm in external beam radiotherapy – a comprehensive review

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