Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer

Takakusagi, Yosuke; Yoshida, Daisaku; Kusano, Yohsuke; Kano, Kio; Anno, Wataru; Tsuchida, Keisuke; Mizoguchi, Nobutaka; Serizawa, Itsuko; Katoh, Hiroyuki; Imura, Koh; Takayama, Yoshiki; Minohara, Shinichi; Kamada, Tadashi

doi:10.21873/invivo.12277

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…Compared with PRT using passive scattering, [ 10 ] the more advanced IMPT with PBS is associated with further dosimetric benefits in sparing the heart in radiotherapy for esophageal cancer and has also been reported as sparing the lungs and heart in radiotherapy for lung cancer [ 36 ]. CIRT using the scanning technique here produced results for esophageal cancer similar to those reported by Takakusagi et al, [ 35 ] which included a similar decline in the D max of the spinal cord, a decrease in the D mean and V5–V60 of the heart, and a lesser decline in the D mean and V5–V20 of the lungs. Those authors used the same PTV for photon and carbon-ion planning; in contrast, in this study, a larger PTV (beam-specific PTV) was applied as in routine clinical practice of particle therapy.…”

Section: Discussionsupporting

confidence: 82%

“…IMCT technique, similar to the technique used in our center) produced better dose homogeneity in the target volume and significantly lower doses to the heart, lungs, spinal cord, and skin in esophageal carcinoma than did photon 3DCRT or volumetric modulated arc therapy (VMAT, a variant of IMRT). Compared to VMAT, significant decreases were achieved with CIRT, especially in the D max to the spinal cord; D mean , V10, V20, V30, and V40 to the heart; and D mean , V5, V10, V20, V30, and V40 to the lungs [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis

Ma,

Ming,

Chen

et al. 2023

Radiat Oncol

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Background Concurrent chemoradiotherapy has been standard of care for unresectable esophageal carcinoma. There were no reports on proton radiotherapy (PRT) plus carbon-ion radiotherapy (CIRT) with pencil beam scanning (PBS) for esophageal carcinoma. This study evaluated the tolerability and efficiency of proton and sequential carbon-ion boost radiotherapy for esophageal carcinoma. Methods From April 2017 to July 2020, 20 patients with primary esophageal carcinoma at stages II–IV were treated with PRT plus sequential CIRT with PBS. A median relative biological effectiveness-weighted PRT dose of 50 Gy in 25 fractions, and a sequential CIRT dose of 21 Gy in 7 fractions were delivered. Respiratory motion management was used if the tumor moved > 5 mm during the breathing cycle. A dosimetric comparison of photon intensity-modulated radiotherapy (IMRT), PRT, and CIRT was performed. The median times and rates of survivals were estimated using the Kaplan–Meier method. Comparison of the dose-volume parameters of the organs at risk employed the Wilcoxon matched-pairs test. Results Twenty patients (15 men and 5 women, median age 70 years) were included in the analysis. With a median follow-up period of 25.0 months, the 2-year overall survival and progression-free survival rates were 69.2% and 57.4%, respectively. The patients tolerated radiotherapy and chemotherapy well. Grades 1, 2, 3, and 4 acute hematological toxicities were detected in 25%, 30%, 10%, and 30% of patients, respectively. Grades 3–5 acute non-hematological toxicities were not observed. Late toxicity events included grades 1, 2, and 3 in 50%, 20%, and 10% (pulmonary and esophageal toxicity in each) of patients. Grades 4–5 late toxicities were not noted. PRT or CIRT produced lower doses to organs at risk than did photon IMRT, especially the maximum dose delivered to the spinal cord and the mean doses delivered to the lungs and heart. Conclusions PRT plus CIRT with PBS appears to be a safe and effective treatment for esophageal carcinoma. PRT and CIRT delivered lower doses to organs at risk than did photon IMRT. Further investigation is warranted.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis

Ma,

Ming,

Chen

et al. 2023

Radiat Oncol

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“…As the subject of this study, a medical article entitled “Dosimetric Comparison Between Carbon-Ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer” was used [ 8 ]. This article was published in a MEDLINE-indexed, English peer-reviewed scientific journal.…”

Section: Methodsmentioning

confidence: 99%

Validation of the Reliability of Machine Translation for a Medical Article From Japanese to English Using DeepL Translator

Takakusagi¹,

Oike²,

Shirai³

et al. 2021

Cureus

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BackgroundThe reliability of DeepL Translator (DeepL GmbH, Cologne, Germany) for the translation for medical articles has not been verified yet. In this study, we investigated the accuracy of machine translation from Japanese to English for a medical article using the DeepL Translator. MethodologyThe subject of this study was an English-language medical article translated from Japanese, which had already been published. The original Japanese manuscript was translated into English using DeepL Translator. The translated English article was then back-translated into Japanese by three researchers. In turn, three other researchers compared the back-translated Japanese sentences with the original Japanese manuscript and calculated the percentage of sentences that retained the intended meaning. ResultsThe mean ± standard deviation of the match rate for the entire article was 94.0 ± 2.9%. The match rate in the Results section was significantly higher than that in the other sections; while the match rate in the Materials and Methods section was significantly lower than the rate in the other sections. Compound sentences and sentences with an unclear subject and predicate appeared to be significant predictors for mismatched translation. ConclusionsThe translation for a medical article from Japanese to English was performed accurately by DeepL Translator.

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“…Another prospective phase II trial for STS of the extremities reported significantly less late toxicity such as fibrosis, edema, and joint contractures in the IMRT group compared to the conventional RT group (26). Notably, CIRT has been shown to exhibit better dose distribution compared to IMRT in several diseases (27)(28)(29)(30), and the above results on IMRT suggest that dose reduction for normal tissues by IMRT may be useful in lowering RT-related toxicity. Therefore, CIRT for STS of the extremities is expected to reduce toxicity, and a previous report has revealed that, among 17 cases of CIRT for STS of the extremities, only one instance of Grade 3 or greater late toxicity, which manifested as femoral fracture, was observed (20).…”

Section: Discussionmentioning

confidence: 94%

Clinical Outcomes of Scanning Carbon-ion Radiotherapy for Soft Tissue Sarcoma of the Extremities

et al. 2022

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Background/Aim: Carbon-ion radiotherapy (CIRT) has been reported to obtain favorable results in the treatment of bone and soft tissue malignancies; however, studies on CIRT for soft tissue sarcomas (STS) of the extremities are limited. Here, we have retrospectively evaluated the therapeutic efficacy and adverse events associated with scanning CIRT (sCIRT) for STS of the extremities at our institution. Patients and Methods: Thirteen consecutive patients with STS who underwent sCIRT between January 2017 and January 2020 were included in the study. The total dose of sCIRT was set at 67.2-70.4 Gy (RBE), which was provided in 16 fractions. Overall survival (OS), progression-free survival (PFS), and local control (LC) were estimated using the Kaplan-Meier method. Toxicity was evaluated using Common Terminology Criteria for Adverse Events v5.0. Results: The cohort consisted of 10 males and 3 females with a median age of 69 years (range=38-95 years). Median duration of observation was 31.8 months (range=7.4-56.4 months). Tumors were localized to the upper extremity in 2 cases and to the lower extremity in 11 cases. Median maximum tumor diameter was 11.7 cm (range=3.0-36.6 cm), while PFS, and LC were 61.5%, 44.9%, and 79.1%, respectively. Acute toxicity of grade 3 or higher was not observed. Late toxicity included grade 3 peripheral nerve palsy and decreased range of motion in 1 and 1 patient each. Late toxicity of Grade 4 or higher was not observed. Conclusion: sCIRT for STS of the extremities demonstrates favorable therapeutic results with acceptable toxicity.

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Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer

Cited by 10 publications

References 28 publications

Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis

Dosimetric rationale and preliminary experience in proton plus carbon-ion radiotherapy for esophageal carcinoma: a retrospective analysis

Validation of the Reliability of Machine Translation for a Medical Article From Japanese to English Using DeepL Translator

Clinical Outcomes of Scanning Carbon-ion Radiotherapy for Soft Tissue Sarcoma of the Extremities

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