Dose-Response Study of N,N-Dimethyltryptamine in Humans

Abstract

These clinical and preliminary quantitative data provide bases for further psychopharmacologic characterization of DMT's properties in humans. They also may be used to compare the effects of other agents affecting relevant brain receptors in volunteer and psychiatric populations.

Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

“…Subjective effects were assessed using the Addiction Research Center Inventory (ARCI; Martin et al 1971), a modified version of the Profile of Moods States (POMS; McNair et al 1971;Johanson and Uhlenhuth 1980), the Hallucinogenic Rating Scale (HRS; Strassman et al 1994), and visual analog scales (VAS). The ARCI and POMS were administered to the participant three times, prior to the change in room temperature, prior to drug ingestion (see Procedures below), and at the end of the session.…”

DMT Models the Near-Death Experience

“…Although there is no universally accepted definition of the NDE, common features include feelings of inner-peace, out-of-body experiences, traveling through a dark region or ‘void’ (commonly associated with a tunnel), visions of a bright light, entering into an unearthly ‘other realm’ and communicating with sentient ‘beings’ (Moody, 1975; Ring, 1980; Greyson, 1983; Martial et al, 2017). Reviewing the phenomenology of NDEs, we have been struck by similarities with the experience evoked by the classic serotonergic psychedelic N , N , Dimethyltryptamine (DMT) (Strassman et al, 1994; Strassman, 2001). …”

“…While the subjective effects of DMT have been researched in the past (Strassman et al, 1994; Gouzoulis-Mayfrank et al, 2005), they have tended to be collapsed into broad categories or dimensions of experience (e.g., visual, somatic and emotional effects) as determined by standard ‘altered states of consciousness’ rating scales (Strassman et al, 1994; Studerus et al, 2010). The degree to which DMT specifically induces near-death type experiences has never been directly measured, however.…”

N,N-Dimethyltryptamine and dichloromethane: Rearrangement of quaternary ammonium salt product during GC–EI and CI-MS–MS analysis

“…It is often referred to as a hallucinogenic substance in an attempt to describe its neuroactive properties which also made it an attractive target for human clinical studies [3][4][5][6][7][8][9]. DMT, and some of its derivatives, are widely abundant in nature and mammalian systems [10,11] and are also easily accessible through a variety of synthetic routes.…”