Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

Freedman, Robert R.; Johanson, Chris E.; Tancer, Manuel E.

doi:10.1007/s00213-005-0149-6

Cited by 111 publications

(119 citation statements)

References 32 publications

(44 reference statements)

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“…Thus, the monkey appears to respond similarly to humans (Freedman et al, 2005) and differently from rats, which become hypothermic after MDMA at 201C ambient temperature (Malberg and Seiden, 1998). The overall implication of this work is that while smaller bodied mammals may be protected from MDMA-induced temperature elevations below B201C, this is unlikely to be the case for macaque monkeys or humans.…”

Section: Discussionmentioning

confidence: 80%

“…This is fortuitous as an interpretive matter because the temperature response can be observed independent of skeletal muscle activity/heat generation. Therefore, the present model most likely reflects heat generation from stimulation of metabolic rate (Freedman et al, 2005) as opposed to skeletal muscle activation. In contrast, rodent models appear to indicate that locomotor increases are usually observed in concert with temperature increases although it should be appreciated that rodent studies have often been conducted without examination of diurnal cycle; thus, close comparisons of effects in lightvs dark-cycle MDMA administration may be necessary to clearly establish Order differences.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Freedman et al (2005) have shown that body temperature is elevated in human volunteers after 2.0 mg/kg (7)MDMA per os and that this effect is similar under T A of 18 or 301C. The present study was designed to evaluate the impact of ambient temperature on thermoregulatory disruption produced by a recreational range of doses of (7)MDMA in rhesus monkeys.…”

Section: Introductionmentioning

confidence: 98%

“…The recreationally abused drug (7)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') elevates body temperature in rats (Brown and Kiyatkin, 2004;Dafters, 1994;Malberg and Seiden, 1998), mice (Carvalho et al, 2002;Fantegrossi et al, 2003), guinea-pigs (Saadat et al, 2004), pigs (Fiege et al, 2003;Rosa-Neto et al, 2004), rabbits (Pedersen and Blessing, 2001), humans (Freedman et al, 2005), and rhesus macaques (Taffe et al, 2005). Sufficiently low ambient temperature conditions can prevent (7)MDMA from inducing hyperthermia or even result in hypothermia in rodent models (Dafters, 1994;Gordon et al, 1991;Miller and O'Callaghan, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…The present study was designed to evaluate the impact of ambient temperature on thermoregulatory disruption produced by a recreational range of doses of (7)MDMA in rhesus monkeys. The hypothesis to be tested was that this larger-bodied laboratory species would be insensitive to the effects of ambient temperature as are humans (Freedman et al, 2005) and therefore differ qualitatively from the rat (Malberg and Seiden, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Huben

Lay

Crean

et al. 2006

Neuropsychopharmacol

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The ambient temperature (T A ) under which rodents are exposed to (7)3,4-methylenedioxymethamphetamine (MDMA) affects the direction and magnitude of the body temperature response, and the degree of hypo/hyperthermia generated in subjects can modify the severity of lasting brain changes in 'neurotoxicity' models. The thermoregulatory effects of MDMA have not been well described in nonhuman primates and it is unknown if T A has the potential to affect acute hyperthermia and therefore other lasting consequences of MDMA. The objective of this study was to determine if the temperature alteration produced by MDMA in nonhuman primates depends on T A as it does in rats and mice. Body temperature and spontaneous home cage activity were monitored continuously in six male rhesus monkeys via radiotelemetry. The subjects were challenged intramuscularly with 0.56-2.4 mg/kg (7)MDMA under each of three T A conditions (18, 24, and 301C) in a randomized order. The temperature was significantly elevated following injection with all doses of MDMA under each ambient temperature. The magnitude of mean temperature change was B11C in most conditions suggesting a closely controlled thermoregulatory response in monkeys across a range of doses and ambient temperatures. Activity levels were generally suppressed by MDMA; however, a 50% increase over vehicle was observed after 0.56 MDMA under the 301C condition. It is concluded that MDMA produces a similar degree of hyperthermia in rhesus monkeys across a range of T A conditions that result in hypothermia or exaggerated hyperthermia in rodents. Monkey temperature responses to MDMA appear to be more similar to humans than to rodents and therefore the monkey may offer an improved model of effects related to MDMA-induced hyperthermia.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Huben

Lay

Crean

et al. 2006

Neuropsychopharmacol

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Clinical Toxicology

BSc

2009

General, Applied and Systems Toxicology

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Clinical toxicology is a discipline within toxicology which is concerned with the impact of drugs and other chemicals on humans. The role of the clinical toxicologist encompasses the traditional therapeutic role, that is the management of patients with acute and chronic poisoning. In addition, the clinical toxicologist will usually provide expert advice via a poisons information service and will be familiar with the occupational and environmental impact of a wide range of chemicals. Clinical toxicologists are also likely to be involved in the development of strategies for the management of major chemical disasters, the evaluation of antidotes used against chemical warfare agents and the assessment of the adverse effects of pesticides and other chemicals whether resulting from a single exposure or chronic low‐level exposure. This chapter describes the components that should make up a comprehensive clinical toxicology service. These include the provision of advice through a poisons information service, an in‐patient treatment service, an out‐patient clinical, occupational and environmental toxicology service, advice to Government, Regulatory and other international bodies, analytical support and the provision of an interpretive service for toxicological analyses, and opportunities for research and training in toxicology. The chapter also describes the presentation and complications of poisoning and details the general assessment and management of the poisoned patient. The chapter concludes with a discussion of the role of toxicovigilance.

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Adjustments in Thermoregulation during Radiofrequency Heating

Gordon¹

2018

Theory and Applications of Heat Transfer in Humans

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Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

Cited by 111 publications

References 32 publications

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Clinical Toxicology

Adjustments in Thermoregulation during Radiofrequency Heating

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